I - Cell Injury, Cell Death and Adaptations Flashcards Preview

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Flashcards in I - Cell Injury, Cell Death and Adaptations Deck (105)
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1

Increase in size of cells resulting in increased size of organ.

Hypertrophy(TOPNOTCH)Robbins Basic Pathology, 9th ed. p. 34

2

Increase in number of cells.

Hyperplasia(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.35

3

Hypertrophy of hyperplasia?Uterus during pregnancy

Both Estrogen stimulated SM hyperthrophy and hyperplasia (TOPNOTCH)Robbins Basic Pathology, 9th ed. p.34

4

Hypertrophy or hyperplasia?Wound healing

Hyperplasia(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.4

5

Hypertrophy or hyperplasia?
Female breast at puberty

Both. (TOPNOTCH) Robbins Basic Pathology 9th ed., p 36

6

Cellular adaptation of non-dividing cells such as myocardial fibers.

Hypertrophy (TOPNOTCH)

7

A 50 y/o male has untreated hypertension for several years. What cellular alteration will be most likely seen in the myocardium?

Hypertrophy (TOPNOTCH)

8

A 40 y/o male underwent partial hepatectomy. What cellular adaptation will the liver most likely undergo?

Hyperplasia(TOPNOTCH)

9

The most common stimulus for hypertrophy of muscle

Increased workload (TOPNOTCH) Robbins Basic Pathology, 9th ed., p.34

10

A 65 y/o male presents with 3-month history of weak stream, straining, and hesitancy. There is no history of prostate cancer. Prostate was severely enlarged without nodules. PSA level is 3 mcg. What cellular adaptation does the prostate most likely undergo?

Hyperplasia(Case of BPH) (TOPNOTCH)

11

Stimulus for hyperplasia in BPH

Hormonal stimulation by androgens. (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 36

12

Cellular adaptation in papilloma virus infection

Hyperplasia (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 36

13

Reduction in the size of an organ or tissue due to decrease in cell size and number

Atrophy(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 35

14

A 60 y/o female has been experiencing hot flushes and irritability. Her uterine epithelium will most likely reveal what type of cellular adaptation?

Atrophy(in menopause)(TOPNOTCH)

15

Chronic production of this cytokine is thought to be responsible for appetite suppression and lipid depletion, culminating in muscle atrophy and marked muscle wasting (cachexia)

Tumor necrosis factor (TNF)(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 35

16

A reversible change in which one differentiated cell type is replaced by another cell type.

Metaplasia (TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

17

A 49 y/o female had a chronic history of heartburn. Biopsy done showed glandular changes in the distal epithelium of the esophagus. What cellular adaptation is present?

Metaplasia. This is a case of Barret's esophagus (squamous to glandular epithelium) (TOPNOTCH)

18

The basal cell changes seen in reflux esophagitis is an example of this adaptive change

Metaplasia (TOPNOTCH)

19

Most common epithelial metaplasia

Columnar to squamous(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

20

Type of metaplasia in trachea and bronchi in habitual cigarette smoking

Columnar to squamous(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 37

21

Its hallmarks are reduced oxidative phosphorylation with resultant depletion of energy stores in the form of ATP and cellular swelling

Reversible injury(TOPNOTCH) Robbins Basic Pathology, 9th ed., p. 38

22

Type of cell death characterized by nuclear dissolution, without complete loss of membrane integrity.

Apoptosis(TOPNOTCHRobbins Basic Pathology, 8th ed. p.7

23

Type of cell death which is energy-dependent, tightly regulated, and associated with normal cellular functions.

Apoptosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.7

24

Type of cell death which results from a pathologic cell injury.

Necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.9

25

Type of cell death associated with inflammation.

Necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

26

It is the irreversible condensation of chromatin in the nucleus of a cell undergoing necrosis or apoptosis. It is characterized by nuclear shrinkage and increased basophilia.

Pyknosis(TOPNOTCH)Robbins Basic Pathology, 9th ed. p.42

27

It is the destructive fragmentation of the nucleus of a dying cell.

Karyorrhexis (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

28

It is the complete dissolution of the chromatin of a dying cell.

Karyolysis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

29

This is the first manifestation of almost all forms of injury to cells.

Cellular swelling(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.8

30

Small clear vacuoles within the cytoplasm, representing pinched-off segments of the endoplasmic reticulum.

Hydropic change or Vacuolar degeneration (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.23