I+M disease MS

Question 1

MULTIPLE SCLEROSIS

What is it?

Answer 1

Chronic autoimmune disease demyelinating the CNS

affects brain, optic nerves, spinal cord –> severe disability

Question 2

MULTIPLE SCLEROSIS

Can be relapsing/progressive/both

Active disease defined as what?

Answer 2

At least 2 big relapses in the past 2 years, despite interferon beta treatment

Question 3

Low levels of vitamin X are believed to be a risk factor for developing multiple sclerosis.

Answer 3

vit D

Question 4

MULTIPLE SCLEROSIS- MANAGING SYMPTOMS

SPASTICITY?

Answer 4

baclofen!!
/ gabapentin/ cannabis extract

Question 5

MULTIPLE SCLEROSIS- MANAGING SYMPTOMS

RELAPSES?

Answer 5

should be referred to specialist.

methylprednisolone

Question 6

MULTIPLE SCLEROSIS- MANAGING SYMPTOMS

OSCILLOPSIA?

Answer 6

OSCILLOPSIA? objects vibrate-> gabapentin/ memantine

Question 7

MULTIPLE SCLEROSIS- MANAGING SYMPTOMS

MOOD ALTERATION?

Answer 7

amitriptyline

Question 8

MULTIPLE SCLEROSIS- MANAGING SYMPTOMS

FATIGUE?

Answer 8

amantadine/ modafanil/ fampridine

Question 9

BACLOFEN- DOSE ADVICE?
risk of what

Answer 9

Increase dose slowly

Risk of sedation/hypotonia (abnormally low level of muscle tone)