IBD Flashcards
(21 cards)
MOA for methotraxate
inhibits dihydrofolate reductase
influecen DNA replication
Example of thiopurine
azethiopurine
MOA for thiopurine
Impair DNA repplication (purine analogue)
Fistula is more common in Crohn’s disease Y/N
Y
Factors contributing to crohn’s disease
genetic pre
environment
dysfunction of the immune response
Diagnosis of the Crohn’s disease
hx and presentation
blood test
stool test to rule out the presence of pathogens
image (ileocolonscopy / endoscopy)
stool calprotectin is a marker for inflammation Y/N
Y
crohn’s disease does not usually invlove ileum Y/N
N
can NSAIDs worse IBD Y/N
Y
it is not necessary to screen active infection before giving Y/N
N
5-amoinosalicylate is an-anti-inflammatory drug Y/N
Y
what is the main gold for induction therapy
get rid of inflammation quickly
induction for crohn’s disease
corticosteroid
maintenance therapy for crohn’s disease
methotrexate
thiopurine
biologics
5-aminosalicylate is a immunposuppresant Y/N
N
based on different site of inflammation UC can be divided into
proctitis / proctosigmoiditis / left-sided / extensive colitis / pancolitis / toxic colitis
sx for UC
abdominal pain
dairrhoea (w blood and mucous)
rectal bleeding
constipation
systematic sx like fever / fatigue / weight loss / tachycardia
malnutrient
anemia
surgeries for UC
toal proctocolectomy
ileoanal pouch anastomosis
pathology of IBD
disturbance of the homeostasis between epithelial cells / immune cells / and gut microbes
stool calprotectin is a essential indicator for IBD Y/N
Y
stool MCS is a indicator for
pathogens
