IBD

Question 1

where does canasa work

Answer 1

rectum

Question 2

where do steroid enemas work

Answer 2

rectum + distal colon

Question 3

where does Rowasa work

Answer 3

rectum + distal colon

Question 4

where does sulfasalazine work

Answer 4

rectum + distal colon + proximal colon + terminal ileium

Question 5

where does balsalazide work

Answer 5

rectum + distal colon + proximal colon + terminal ileium

Question 6

where does asacol work

Answer 6

rectum + distal colon + proximal colon + terminal ileium + ileium

Question 7

where does pentasa work

Answer 7

rectum + distal colon + proximal colon + terminal ileium + ileium + jejunam

Question 8

what are the trade names, dosing forms and strengths of sulfasalazine?

Answer 8

1. Azulfidine 500 mg tablet (available in delayed rel. too)

2. En-tabs 500 mg delayed release

Question 9

what are the trade names, dosing forms and strengths of Mesalamine

Answer 9

1. canasa 1000 mg suppository
2. rowasa 4g/60mL enema
3. Delzicol 400 mg delayed rel. capsule
4. asacol HD 800 mg delayed rel. tablet
5. Lialda 1.2 g delayed rel. tablet
6. Apriso 375 mg delayed rel. & extended rel. capsules
7. Pentasa 250 mg & 500 mg extended rel. capsule

Question 10

what forms of mesalamine are once daily dosing

Answer 10

apriso and lialda

Question 11

where does lialda work

Answer 11

rectum + distal colon + proximal colon + terminal ileium

Question 12

where does delzicol work

Answer 12

rectum + distal colon + proximal colon + terminal ileium

Question 13

whre does apriso work

Answer 13

rectum + distal colon + proximal colon + terminal ileium

Question 14

where does olsalazine work

Answer 14

rectum + distal colon + proximal colon

Question 15

what are the trade names, strengths, and forms of olsalazine?
balsalazide?

Answer 15

olsalazine = Dipentum 250 mgh capsule
balsalazide = Colazal 750 mg capsule

Question 16

all 5-ASA’s do what

Answer 16

treat inflammation of rectum

Question 17

what is budesonides:

1. trades names and sites of action
2. side effects
3. counseling points

Answer 17

1. a. Entocort EC = ileum and right colon
   b. Uceris = throughout colon
2. extensive first pass metabolism, so systemic exposure and SEs are minimal
3. do not crush or chew and avoid grapefruit juice

Question 18

what are budesonides trade names and dosage forms

Answer 18

1. Entocort EC = controlled ileal release oral capsule

2. Uceris = controlled colon release oral tablet (for UC in remission)

Question 19

what are sulfasalazine counseling points

Answer 19

1. take with meals
2. photosensitivity
3. orange yellow discoloration of urine and skin
4. do not crush enteric-coated tablets
5. take folic acid supplements

Question 20

what are counseling points with mesalaminew

Answer 20

1. w/ or w/out food depending on product
2. yellow brown discoloration of urine
3. don’t crushj or chew {P forms
4. avoid antacidds and anti-secretory meds w/ ph dependent PO forms
5. retain rectal suppository forms for 1-3 hours
6. retain enema forms for 8 hours