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GI > IBD & Malapsorption > Flashcards

IBD & Malapsorption Flashcards

1
Q

Which enzymes digest carbs

A
  • salivary amylase
  • pancreatic amylase
  • small intestine maltase
  • small intestine lactase
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2
Q

Which enzymes digest proteins

A
  • gastric pepsin
  • pancreatic trypsin
  • small intestine peptidases
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3
Q

Which enzymes digest nucleic acids

A
  • pancreatic nuclease
  • small intestine nucleosidases
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4
Q

Which enzyme digests fat

A
  • pancreatic lipase
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5
Q

Describe malabsorption

A

broad spectrum; associated with diminished intestinal absorption of one or more dietary nutrients

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6
Q

Describe the 3 steps of nutrient absorption

A
  1. luminal processing (breakdown)
  2. absorption into intestinal mucosa
  3. transport into circulation
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7
Q

Describe global vs partial/isolated malabsorption

A
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8
Q

Describe some causes & clinical manifestations of global malabsorption

A

Causes
- diffuse mucosal involvement
- reduced absorptive area

Manifestations
- steatorrhea
- weight loss

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9
Q

Describe fat absorption

A
  • normally +94% absorbed
  • starts in upper GI with emulsification
  • majority absorbed by pancreatic lipase & colipase
  • influenced by type of dietary lipid & presence of other nutrients
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10
Q

Describe the presentation and lab findings for fat malabsorption

A

presentation
- steatorrhea
- diarrhea without flatulence
- pale & voluminous

Labs
- >6% fractional fat excretion

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11
Q

Describe carb absorption & malabsorption

A
  • only absorbed in small intestine
  • lactose malabsorption only clinically important disorder of carb absorption
  • deficiency in pancreatic amylase, reduced disaccharidase activity & decreased intestinal surface area
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12
Q

Describe the differences between primary & secondary carb malabsorption

A
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13
Q

Describe the presentation of carb malnutrition

A
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14
Q

Describe protein absorption

A
  • begins in stomach with gastric pepsin (depends on other dietary constituents, gastric motility, pH)
  • remainder absorbed in small intestine
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15
Q

Describe a few causes of protein malabsorption

A
  • Impaired pancreatic protease: chronic pancreatitis, CF
  • Generalized reduction of intestinal surface area: hypoalbuminemia, protein malnutrition, kwashiorkor
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16
Q

Describe the presentation and lab findings of protein malnutrition

A
17
Q

Vitamin/mineral/trace element malabsorption results in a deficiency in the following…

A
  • calcium
  • magnesium
  • vit B12
  • iron

(MC seen in bariatric surgery population)

18
Q

Describe the etiology of IBD

A
19
Q

Describe the etiology of Crohn’s disease

A
20
Q

Describe the etiology of ulcerative colitis

A
21
Q

Describe the presentation of crohn’s disease

A
22
Q

Describe the presentation of ulcerative colitis

A
23
Q

describe the diagnosis of crohn’s

A
23
Q

describe the diagnosis of ulcerative colitis

A
24
Q

Describe the treatment of IBD

A
25
Q
A

GI (17 decks)

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