IC5: Headache Flashcards

(33 cards)

1
Q

What is SNNOOP10 used for?

A

red flags for secondary HA

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2
Q

What does SNNOO stand for?

A
  1. systemic sx (fever)
  2. neoplasm hx
  3. neurologic deficit
  4. onset of HA sudden
  5. older age (over 50)
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3
Q

What does P10 stand for

A
  1. pattern of change or recent onset
  2. positional HA
  3. precipitated by sneezing or exercise
  4. papilledema
  5. progressive HA with atypical presentation
  6. pregnancy
  7. painful eye
  8. post-traumatic onset of HA
  9. pathology of immune system
  10. painkiller overuse or new drug at HA onset
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4
Q

Differentiate TTH and migraine in terms of pain location

A

TTH - bilateral
Migraine - unilateral usually

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5
Q

Differentiate TTH and migraine in terms of pain quality

A

TTH - tightening
Migraine - pulsating, throbbing

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6
Q

Differentiate TTH and migraine in terms of pain intensity

A

TTH - mild to moderate
Migraine - moderate to severe

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7
Q

Differentiate TTH and migraine in terms of effect of/on routine activities

A

TTH - not aggravated by routine activities
Migraine - aggravated by or causes the avoidance of routine activities

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8
Q

Differentiate TTH and migraine in terms of duration

A

TTH - 30mins to 7 days
Migraine - 3 to 72h

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9
Q

What is the key to NPM in TTH management?

A

Patient education to identify triggers, recommend a headache diary (take note of events and quality of HA)

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10
Q

What are pharmacological management options for TTH? (3 + 3)

A

acute - paracetamol (w/wo caffeine), aspirin, NSAIDs (ibuprofen, naproxen)

prophylactic - amitriptyline, mirtazapine, venlafaxine

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11
Q

What are non-pharmacological management options for TTH?

A

CBT, biofeedback, lifestyle modification (including sleep hygiene)

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12
Q

What are the 5 migraine phases?

A

Prodrome
Aura
HA (ictal)
Postdrome
Interictal

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13
Q

Which symptoms are experienced in most of the phases? (5)

A

Photophobia, phonophobia, fatigue, neck discomfort, nausea

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14
Q

What actions outline the prodrome phase? (2)

A

Hypothalamus activation
Neuropeptides involved in homeostatic functions

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15
Q

What action outlines the aura phase?

A

Cortical spreading depression (CSD) resulting in slow-spreading depolarisation within the grey matter that inhibits cortical activity

CSD may also activate the trigeminovascular system, driving aura symptoms

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16
Q

What action outlines the ictal phase?

A

neuropeptides (including CGRP) sensitise the trigeminovascular system and create a state of hypersensitivity

17
Q

What action outlines the postdrome phase?

A

Similar to prodrome:
hypothalamus activation and neuropeptide release

18
Q

What action outlines the interictal phase?

A

Some regions of the brain remain abnormally activated after headache cessation, including the olfactory regions, the midbrain, and the hypothalamus

19
Q

How is episodic migraine diagnosed

A

during a lifetime, ≥ 5 migraine attacks lasting 4-72 hours

20
Q

How is chronic migraine diagnosed

A

≥ 15 MHDs and ≥ 8 MMDs over > 3 months

21
Q

What is an MHD

A

monthly HA day

a day with migraine-type or tension-type headache

22
Q

What is an MMD

A

monthly migraine day

at least 2/4: unilateral, pulsating, mod/severe, avoid physical activity

if no aura, at least 1/2: photo/phonophobia, n/v

23
Q

Which two classes of medications are specifically implicated in medication overuse HA?

A

Opioids and barbituates

24
Q

What is the first line and second line for acute migraine treatment?

A

First line: analgesics like NSAIDs or paracetamol/aspirin if NSAIDs are contraindicated

Second line: triptans

25
What are the triptans' MOA and what do they inhibit? (3)
Triptans are agoists of 5-HT(1B) and 5-HT(1D) receptors, decreasing trigeminal neuron activity they inhibit 3 things: - cerebral blood vessels, -vasoactive peptide release by trigeminal neurons - nociception
26
Which agents can be used for CGRP receptor blockade? (2)
erenumab, gepants
27
Which agents can be used for CGRP blockage? (1)
monoclonal antibodies like eptinezumab
28
Which agents stimulate 5-HT (1B/1D) receptors
triptans
29
Which agents stimulate 5-HT (1F) receptors
ditans
30
What can be used for adjunctive treatment?
Metoclopramide for nausea
31
What are the contraindications to cafergot use? (4)
CVD, CHD, recent stroke, uncontrolled hypertension (due to vasoactive effect)
32
What does AHS recommend for when to start preventative treatment?
in terms of HA days / month, start if ≥ 6 days w no disability ≥ 4 days w some disability ≥ 3 days w severe disability
33
What 2 classes of drugs can be given for preventative treatment of migraines? (2 + 2)
ASM (topiramate, valproate) BB (propranolol, metoprolol)