ID and Endo Flashcards
(39 cards)
MCC of EOS and LOS in term? EOS in VLBW?
- EOS: GBS, E. Coli, strep
- LOS: CONS, E. Coli, staph
- VLBW: E. Coli
Chocolate like amniotic fluid?
What does placenta have?
What other associated physical findings?
Listeriosis
micro-abscesses
discoloration/jaundice around umbilicus, granulomatosis infantisepticum
What is the rubella triad?
Late manifestations of rubella?
bones and eyes?
- cataracts, hearing loss, and CHD (PPS or PDA)
- thyroid disease, DM, and immunodeficiency
- celery stalking of bones and salt and pepper retinopathy
Classic triad for toxo?
Transmission during pregnancy?
When do they present?
Treatment?
- chorioretinitis, intracranial calcifications, and hydrocephalus
- Risk of transmission greatest in later pregnancy, but disease is worse if transmitted early
- preterm infants at ~3 months, term later
- pyrimethamine and sulfadiazine AND folate x1 year
Treatment for omphalitis?
vancomycin and cefotaxime
When does T4 synthesis begin in fetus?
14 weeks (T4 14)
When does the fetal thyroid begin to take up iodine?
10 weeks (10dine)
What is the most common system involved with hypothyrodism?
cardiac
About what % of infants affected with toxo will have visual/learning disabilities?
80%
When is C-section indicated for HIV+ mom?
viral load >1000
When does TSH peak?
30 minutes after birth?
Primary thyroid hormone in fetus?
rT3
When does PTH peak?
48 hours (follows calcium decrease after delivery, nadirs at 24 hours of life)
Which 2 adrenal hormones are not produced by the fetus?
3B-HSD and aromatase are produced by the placenta
- limited cortisol production before 30 weeks
- if placenta is deficient in aromatase and fetus is female, they have ambiguous genitalia d/t too much testosterone –> mother gets hirsuitism
Which of the following is NOT used to monitor hydrocort/fludrocort dosing in CAH?
- blood pressure, linear growth, bone age, hand/wrist X-rays, renin, aldosterone, ACTH, andostenedione
ACTH
What two lesions will culture negative
Chlamydia and SSSS
In what infectious condition do you give steroids as an adjunct for meningitis treatment?
TB
electrolyte abnormality with ampho B?
hypomagnesemia (think of it if you start ampho B after SIP and see seizures)
What are 4 causes of undervirilized male? 4 causes of overvirilized female?
male: 3 beta, 5 alpha, 17 (both alpha and beta), AIS
female: 3 beta, 11 beta, 21 alpha, aromatase deficiency
What viruses are dsDNA? ssDNA?
dsDNA: CMV, HBV, HSV, VZV
ssDNA: parvo
everything else is ssRNA
Which of the following is increased in preterm compared to term: T4, T3, TBG, thyroglobulin?
thyroglobulin
- What stimulates Wolffian duct differentiation?
- What stimulates Mullerian duct regression?
- What stimulates formation of scrotum and penis in 1st trimester?
- What stimulates phallic enlargement and testicular descent in 2nd trimester?
- Testosterone (formed by leydig cells and driven by placental hcg)
- MIS
- hCG (1st trimester)
- LH (2nd trimester)
Which one of the following is NOT used to evaluate an undervirilized male:
MIS, testosterone, DHT, LH, FSH, renin
renin (use in CAH)
Where does the wolffian duct come from?
Where does the mullerian duct come from?
Wolf: mesonephros
Muller: paramesonephric duct
