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PHAR 255 - Therapeutics (3) > ID DOSAGE REGIMENS & MONITORING FAAAAAAK > Flashcards

ID DOSAGE REGIMENS & MONITORING FAAAAAAK Flashcards

1
Q

Mild - Mod C. Difficile infection: Provide all of the possible regimens.

A

1st Line:
Vanco 125mg QID x 10-14d

2nd Line:
Fidaxomicin 200mg BID x 10d

OR

Metro 500mg TID x 10-14d

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2
Q

Severe, Uncomplicated C. Difficile infection: Provide all of the possible regimens.

A

1st Line:
Vanco 125mg QID x 10-14d

2nd Line:
Fidaxomicin 200mg BID x 10d

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3
Q

Severe, Complicated C. Difficile infection: Provide all of the possible regimens.

A

1st Line:
Vanco 125 - 500mg QID x 10-14d

+

Metro 500mg IV q8h

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4
Q

1st Recurrence of C. Difficile: What are the possible regimens?

A

Exact same options as Mild - Moderate (repeat courses of therapy).

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5
Q

2nd Recurrence of C. Difficile: What are the possible regimens?

A

Implement Pulsatile Vanco…

125mg QID x 2wks,
125mg TID x 1wk
125mg BID x 1wk
125mg OD x 1wk
125mg EOD x 2-8wks

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6
Q

What do we monitor for in C. difficile infection?

A

-Diarrhea / Fever / Abdom Pain / Sx Resolution

-XXX to Anti-Motility Agents

-WBC / Electrolytes

-Therapy Adherence

-Drug Side Effects

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7
Q

Latent Tuberculosis regimens: What are they?

A

Rifampin OD x 4mths
INH + Rifapentine OW x 3mths
INH OD x 9mths

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8
Q

Active Tuberculosis regimens: What are they?

A

Quad (RIPE) x 2mths THEN
INH + Rifampin x 4mths (6 total)

INH + Rifampin x 9mths (if Pyrazinamide isn’t present in regimen)

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9
Q

Initial / Baseline TB Monitoring Parameters…

A

-Weight / Physical Exam

-Vision Acuity

-CXR

-LFTs / CBCs / SCr

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10
Q

TB Efficacy Monitoring Parameters…

A

-Sputum q1-2wks (until 2 consecutive negatives)

-Wt / Vision / LFTs / CBCs / SCr (monthly for therapy duration)

-Drug Specific Interactions & Side Effects

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11
Q

< 1mth, Empiric Meningitis treatment: Go..

A

Ampicillin + AMG

OR

Ampicillin + Cefotaxime

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12
Q

1mth - 50yrs, Empiric Meningitis treatment: Go…

A

Vancomycin + 3rd Gen CS

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13
Q

> 50yrs, Empiric Meningitis treatment: Go…

A

Vancomycin + 3rd Gen CS + Ampicillin

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14
Q

Meningitis targeted treatment against S. pneumoniae.

A

Vanco + 3rd Gen CS (10-14d)

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15
Q

Meningitis targeted treatment against N. meningitidis.

A

One of the following:

3rd Gen CS
Ampicillin
Pen G

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16
Q

Meningitis targeted treatment against L. monocytogenes.

A

Ampicillin

OR

Pen G (+/-) AMG

17
Q

Meningitis targeted treatment against S. agalactiae.

A

Ampicillin

OR

Pen G

18
Q

Meningitis targeted treatment against H. influenzae.

A

3rd Gen CS

19
Q

Meningitis targeted treatment against E. coli.

A

3rd Gen CS

20
Q

Monitoring parameters for Meningitis patients…

A

-C & S

-CBCs

-Lumbar Puncture 2d after 1st (if conducted)

-Sx q4h

-DDIs / Side Effects

21
Q

Empirical Endocarditis treatment if bacterial source is unknown & S. aureus NOT suspected…

A

Pen G

OR

Ampicillin + AMG

22
Q

Empirical Endocarditis treatment if bacterial source is unknown & S. aureus IS suspected…

A

Pen G + Cloxacillin

OR

Ampicillin + Cloxacillin + AMG

OR

Vancomycin + AMG

23
Q

Endocarditis with confirmed S. pneumoniae culture (& patient has Native Valves)…

A

Pen G x 4wks

OR

Ceftriaxone x 4wks

24
Q

Endocarditis with confirmed S. pneumoniae culture (& patient has Prosthetic Valves)…

A

Pen G x 6wks

OR

Ceftriaxone x 6wks

(Both +/- AMG for first two weeks)

25
Q

Endocarditis with MSSA (& patient has Native Valves)…

A

Beta Lactam (ie. Oxacillin / Nafcillin) x 6wks

OR

Cefazolin x 6wks (if Pen Allergy)

26
Q

Endocarditis with MSSA (& patient has Prosthetic Valves)…

A

Beta Lactam (ie. Oxacillin / Nafcillin) + AMG + Rifampin x 6wks

OR

Cefazolin + AMG + Rifampin x 6wks

27
Q

Endocarditis with MRSA (& patient has Native Valves)…

A

Vancomycin x 6wks

28
Q

Endocarditis with MRSA (& patient has Prosthetic Valves)…

A

Vancomycin + AMG + Rifampin x 6wks

29
Q

Endocarditis with confirmed Enterococci (either Native Valve or Prosthetic Valve)…

A

Ampicillin + AMG x 4-6wks

OR

Pen G + AMG x 4-6wks

30
Q

Monitoring parameters for Endocarditis patients…

A

-C & S (q24h til negative)

-DDIs / Side Effects

-Signs & Sx Resolved

-HF Exacerbations Resolved (ie. SOB / Edema / Sudden Wt Gain)

-Improvement of Heart Murmur (but will not go away entirely)

PHAR 255 - Therapeutics (3) (7 decks)

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