ID2: Drug Indications

Question 1

Penicillin

Answer 1

Pharyngitis (Dental Abscess)Serious GAS - necrotizing fasciitisEndocarditis (Strep viridans)Meningitis (Meningococcal Pneumococcal)Pneumococcal pneumoniasyphilis*

Question 2

Ampicillin

Answer 2

Sinusitis, otitis media, bronchitisPyelonephritis (AMP + GENT)Biliary/intra-abdominal Sepsis (AMP+GENT+Metronidazole)Enterococcal endocarditis (AMP+GENT)Meningitis: L. monocytogenes (neonates, elderly, immunocompromised)Amoxicillin has similar spectrum of action

Question 3

Nafcillin

Answer 3

Staph aureus, MSSACellulitisOsteomyelitisEndocarditisLine sepsis/bacteremia

Question 4

Extended Spectrum Penicillins

Answer 4

Nosocomial Infections - pneumonia, UTIIntra-abdominalneutropenic

Question 5

Cefazolin (1st gen)

Answer 5

pre-op for surgical prophylaxisskin & soft tissuebone & joint

Question 6

2nd generation Cephalosporins

Answer 6

anaerobesintra-abdominal abscesses

Question 7

Ceftriaxone (3rd gen)

Answer 7

CAPmeningitis (crosses BBB)

Question 8

Ceftazidime (3rd gen)

Answer 8

pseudomonasHA-infections

Question 9

Cefepime (4th gen)

Answer 9

Nosocomial infectionsfever, neutropenia

Question 10

Ceftaroline (5th gen)

Answer 10

resistant gm (-)no pseudomonas coverageskin & soft tissue (CA)bacterial pneumoniaCA-MRSA

Question 11

Carbapenems

Answer 11

gm (-) infectionsserious HA infectionsanaerobesperitonitis or abscess - intra-abdominal infections

Question 12

Aminoglycosides

Answer 12

gm (-) aerobicZoonotic Infections: Tularemia (Francisella tularensis)Plague (Yersinia pestis)

Question 13

Anaerobic drugs

Answer 13

Clindamycin (above the diaphragm)Metronidazole (below the diaphragm)

Question 14

Anaerobic bacteria

Answer 14

BacteroidesPrevatellaClostridiaFusobacteriumPeptostreptococci

Question 15

Fluoroquinolones Non-respCiprofloxacin

Answer 15

gm (-) rodspseudomonasshigellasalmonellacampylobacterS. aureus (but resistance can develop)Anthrax

Question 16

Fluoroquinolones RespMoxifloxacinLevofloxacin

Answer 16

anaerobes - moxigm (+) cocciatypical bacteriagm (-) H influenzae & EnterobacteriaceaeCAPmycobacteria

Question 17

CA-MRSA

Answer 17

TMP/SMXClindamycinLinezolid

Question 18

HA-MRSA

Answer 18

VancomycinLinezolidDaptomycinSynercid

Question 19

Doxycycline

Answer 19

Lyme Disease (B. burgdorferi)Rocky Mountain Spotted Fever (Rickettsia)Cat Scratch Disease (Bartonella henslae)Q Fever (Coxsiella burnettii)Psittacosis (Chlamydophila psittaci)Erchiliosis (E. chaffeensis - HME, A. phagycytophilum - AGA)