II - Adrenergic Pharmacology

Question 1

Norepinephrine - primary transmitter at the symphathetic postganglionic neuron-effector cell synapse in most tissues.

Answer 1

Dopamine/Norepinephrine: Dopamine vasDILATES renal blood vessels while Norepinephrine vasCONTRICTS them.

Question 2

Step 1. - SYNTHESIS. Tyrosine is hydroxylated by tyrosine hydroxylase to DOPA.

Answer 2

inhibited by METYROSINE

Question 3

STEP 2. - STORAGE. Norepinephrine and dopamine are transported into vesicles.

Answer 3

inactivated by by monoamine oxidase in the cytoplasm. Vesicular transport nhibited by RESERPINE.

Question 4

STEP 3. - RELEASE. Entry of calcium triggers interaction among SNARE proteins (VAMPs and SNAPs).

Answer 4

inhibited by GUANETHIDINE. Promoted by AMPHETAMINES and TYRAMINES.

Question 5

Step 4. - TERMINATION. Diffusion and re-uptake via NET and DAT in synaptic cleft.

Answer 5

inhibited by COCAINE AND COMT Inhibitors.