III - Tissue Repair, Healing and Fibrosis Flashcards Preview

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Flashcards in III - Tissue Repair, Healing and Fibrosis Deck (72)
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61

The hallmark of tissue healing is:

Granulation tissue (TOPNOTCH)

62

Vitamin C retards wound healing because

Collagen synthesis is inhibited (TOPNOTCH)

63

Phase of cutaneous wound healing: formation of granulation tissue, proliferation and migration of connective tissue cells and re-epithelialization of wound surface

Proliferation (2nd phase) (TOPNOTCH)

64

Phase of cutaneous wound healing: ECM deposition, tissue remodeling and wound contraction

Maturation (3nd phase) (TOPNOTCH)

65

Its characteristic feature is the presence of new small blood vessels and proliferation of fibroblasts

Granulation tissue (TOPNOTCH)

66

True or False. Granulation tissue is more prominent in healing by secondary union.

True (TOPNOTCH)

67

Hypertrophic scar is due to accumulation of excessive amount of___.

Collagen (TOPNOTCH)

68

In wound healing, collagen is produced by:

Myofibroblasts(TOPNOTCH)

69

A 33 year old man sustains a stab injury on his right forearm. Two days after the incident, what can be seen in his stab wound? (A) dense collagen deposition (B) pink amorphous material devoid of cellular elements (C) accumulation of fibroblasts and macrophages (D) fibroblasts and capillaries in a loose extracellular matrix

fibroblasts and capillaries in a loose extracellular matrix (TOPNOTCH) Robbins Basic Pathology, 8th ed. Pp 70-71

70

What is expected in the surgical scar of a 21 year old who underwent appendectomy one month ago? (A) Absence of dermal appendages (B) fibroblasts and capillaries in a loose extracellular matrix (C) intense intlammation and large amounts of granulation tissue (D) peak neovascularization

Absence of dermal appendages (Healing by First Intention) (TOPNOTCH) Robbins Basic Pathology, 8th ed. Pp74-76

71

A 19 year old black male who got his right earlobe pierced 3 months ago developed a raised scar on that area. If examined microscopically, what should be seen? (A) dense collagen deposited in bundles (B) thickened stratum corneum of the epidermis (C) large amounts of granulation tissue (D) neutrophil aggregates with necrotic centers

dense collagen deposited in bundles (TOPNOTCH) Robbins Basic Pathology 8th ed, p 77

72

What is the cell responsible for wound contraction, especially in wounds that heal by second intention?

myofibroblast (TOPNOTCH) Robbins Basic Pathology 8th ed, p 76