IM Flashcards
(5628 cards)
What is Gamma gap?
Elevated serum protein with normal Albumin. Can be seen in MM.
Difference between MM and MGUS(monoclonal gammopathy of undetermined significance) ?
MM : Pr> 3gr
BM plasma cell> 10% of BM
B2 Microglobuline
Charactristics of Legionella?
Bradycardia inspite of high fever, GI symtoms (Diarrhea, abdominal pain), neurologic symptoms( confusion), hyponatremia, Hepatitis, negative (-) gr stain because it’s intracellular, diagnosis is based on urine test for Legionella Ag. Tx: Macrolids or Fleuroquinolon.
Respiratory and GI symptoms in a Post BMT patient, what’s the most likey cause?
CMV
Metabolic syndrome?
Hdl50 in women Bp> 130/80 TG>150 Obesity > 40 in men > 35 in women FBS>100
Tx for PBS( primary biliary cirhosis)?
Ursodeoxycolic
2 drugs that improve CHF symptoms but does not effect on mortality
Digoxin and Furosmide
Why pulse paradox in asthma and copd
Because chest expansion during inpiration in asthma and copd will cause more negative pressure in thorasic cavity and more than 10 mm hg decrease in bp during inspiration
CPPD in?
Pseudogout, Hemochromatosis
MI complications? How would you recognize them?
Ventricular free wall rupture, papillary muscle rupture, Aortic aneurysm, Pericarditis. Left ventricular aneurysm happens months after MI and there’s ST elevation and deep Q wave. Those ruptures happen early.
Preclampsia risk factors:
Maternal age, nuliparity, DM, Renal insufficiency, chronic HTN, history of preclampsia.
Charactristics of open angle and closed angles glocuma?
Open angle glucoma is painless, in african americans, cupping, peripheral vision loss. Closed angles glucoma is painfull and there is blurred vision and nausea and vomitting.
Drug induced liver diseases:
Cholestasis with: Chlorpromazine, nitrofurantoin, erythromycine, anabolic steroids.
Fatty liver with: Tetracycline, Valproat, Anti - retrovirals
Hepatitis: Halothane, Phenytoin, Isoniazide, alpha methyldopa
Fulminant hepatitis: ccl4, Acetaminophen,
Granolumatosis: Alluporinol, Phenylbutazone
Causes of gout:
1- overproduction: cancer, chemotherapy, hemolysis
2-undersecretion: ketoacidosis, Renal insufficiency, lactate acidosis
3-Meds: ASA, Thiazides
What you have in mind in DDx of gout?
Infection bcz gout can be accompanied by fever.
Tx options for gout?
Nsaids, colchicine, corticosteroids
Why Losartan is better than ASA or Thiazides for TX of gout?
Bcz of increasing risk of hyperuricemia with ASA and Thiozides.
Side effects of Colchicine?
Effect on BM and Neutropenia, Diarrhea
Mechanism of action: Allopurinol Pegloticase Febuxostat Probenecid Sulfapyrazone
Alluporinol: decrease production of uric acid
Pegloticase: Increase metabolism of uric acid
Febuxostate: inhibit Xantin Oxidase
Probenecid and Sulfipirazone: increase uric acid excretion
When do we use Alluporinol
When we can’t prescribe other meds
Alluporinol side effects:
Toxic epidermal necrolysis, Steven Johnson, Hypersensitivity reactiond ( rash, Allergy, Hemolysis)
Disease associated with CPPD:
DM, Hemochromatosis, Pseudogout, Wilson, Hypoparathyroidism
1-causes of Dopuyteren contacture
2- treatment of it?
Genetic, Cirrhosis, Alcohol
Lidocain, Collagenase, Lidocain
Felti Syndrome?
Kaplan Syndrome?
Felti Syndrom: RA+ neutropenia+ splenomegaly
Kaplan: RA+ Pneumoconiosis+ lung nodules