IM mix UWQ - may30th 2021 Flashcards
(94 cards)
chemotherapy at risk for opportunistic pathogens?
gram-negative bacillus Pseudomonas aeruginosa.
-> ecthyma gangrenosum
Pyoderma gangrenosum
sym?
neutrophilic dermatosis
-> seen with IBD and arthropathies.
dev rapidly –> begin as a cutaneous papule/nodule–> quickly matures into a painful, purulent ulcer with violaceous borders.
lose weight to achieve and maintain a healthy weight.
rx?
each 10 kg (22 lb) of weight loss can lower blood pressure by ~6 mm Hg;
-> weight loss is one of the most effective nonpharmacologic interventions
Pain in the groin, buttock, or lateral hip (trochanteric) region and can radiate to the lower thigh or knee.
- > mild pain and brief stiffness with prolonged rest <30 mins
- .> worst pain usually occurs with activity and weight bearing
dx?
XR finding?
osteoarthritis of the hip
x-ray:
loss of joint space, osteophyte formation, and subchondral sclerosis.
loc: Knees Hips DIP joints 1st carpometacarpal joint
Lower back pain
rx?
acute <4 weeks: moderate exercise, NSAIDS
subacute/ chronic >12 wks:
exercise rx, TCA, duloxetine
secondary prevention: exercise therapy, education
Vs/ back brace not useful for preventing LBP
high dose drug prolong use>3 month
Constitutional symptoms (eg, fever, malaise)
Arthralgias
Serositis (eg, pleuritis, pericarditis)
Rash (less common compared with SLE)
Dx?
rx induced?
Drug-induced lupus erythematosus
procainamide, hydralazine, penicillamine
Others:
minocycline,
TNF-α inhibitors (eg, etanercept, infliximab),
isoniazid
RF: slow acetylator status
Hypertrophic osteoarthropathy
sym?
- > underlying lung disease (eg, adenocarcinoma, chronic pulmonary infection)
- > arthralgia.
- > skin thickening and digital clubbing
Microscopic polyangiitis and granulomatosis with polyangiitis
(wegener)
-> necrotizing, small-vessel vasculitides
sym?
lab?
- > acute-onset fever
- > tracheopulmonary disease.
- > rhinosinusitis, hematuria, and rash (eg, palpable purpura)
- > saddle nose , hearing loss
lab: c-ANCA: PR3+, MPO+
Osteogenesis imperfecta
defective formation of type 1 collagen,
- > bone, tendons, ligaments, skin, teeth, and sclera.
- > childhood with fragility fractures, short stature, impaired hearing, blue sclera
osteomalacia
-> fatigue, bone pain, and hypophosphatemia
lab?
Asso with: celiac dx, CKD, Chronic liver dx, bypass surgery
↑ Alkaline phosphatase ↑ PTH ↓ Serum calcium & phosphorus ↓ urinary calcium ↓ 25 OH-D levels
X-rays: thinning of cortex with reduced bone density
-> reduced mineralization of the osteoid matrix
Bilateral & symmetric pseudofractures (Looser zones)
amiloride
moa?
sym?
rx?
potassium-sparing diuretic that blocks the epithelial sodium channel (ENaC) in the renal collecting system.
sym:
hyperkalemia
met acidosis
rx: switch rx -> CCB recheck in 1-2 wks
severe hyperkalemia rx:
IV ca + insulin + glc
Goodpasture syndrome)
sym?
hx?
hx:
anti–glomerular basement membrane (anti-GBM) disease
renal bx: formation of antibodies to the alpha-3 chain of type IV collagen
-> linear IgG deposition along the glomerular basement membrane IF
sym:
1. renal : pnuria <3.5g/day, hematuria
2. resp: hemoptysis , SOB
PCP
sym?
HIV patients with CD4 counts <200/mm3.
- > Fever, dyspnea, and nonproductive cough
- > Fatigue, weight loss, and chills
acute-onset, severe headache
vomiting, photophobia, neck stiffness, and lethargy
dx?
Rx?
subarachnoid hemorrhage (SAH) -> ruptured saccular aneurysm
isolated CN palsies -> sign of a compressing aneurysm: Oculomotor nerve (CN III) palsy -> pupillary dilation: loss of PNS, ptosis and down and out due to loss of somatic innervation.
Full or partial oculomotor nerve palsy: enlarging or ruptured aneurysm of the adjacent PCA
Dx: CT angiography
Cavernous sinus thrombosis
sym?
fever, headache, and periorbital swelling.
-> palsy of ICA, CNs III, IV, and VI , V1, v2 resulting in ophthalmoplegia.
JC virus reactivation
untreated AIDS
dx?
Progressive multifocal leukoencephalopathy
MRI:
asymmetric white matter lesions;
no enhancement/ edema
Community acquired pneumonia (CAP)
- > pulmonary parenchymal infection, focal consolidation
sym: develop acutely and include fever, cough, pleuritic chest pain, and dyspnea. - > Tachycardia, tachypnea, focal crackles (right lower lobe)
dx?
> caused by bacterial (majority), viral (30%), or fungal pathogens.
-> strep pneumonia
dx: CXR
- > Symptomatic treatment alone insufficient due to the risk of secondary bacterial pneumonia
chronic pancreatitis
CT: pancreatic atrophy and calcifications
RF: smoking + Etho
rx?
destruction of acinar and islet cells
-> pancreatic exocrine insufficiency.
Pancreatic secretion is stimulated by cholecystokinin (CCK).
Normally, pancreatic enzymes breakdown CCK-releasing protein, thereby limiting CCK release.
pancreatic insufficiency, pancreatic enzyme deficiency
- > release of high volumes of CCK
- > pancreatic hyperstimulation
rx:
Pancreatic enzyme supplementation, lipase, protease, and amylase
obstructed pancreatic duct
dx?
Endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and/or stent placement
burning or itching of the lids, discharge (which may be associated with crusting of the eyelashes in the morning),
- > often a foreign body sensation in the eye
- > scaling at the lid margin
Dx?
Blepharitis
-> inflammation at the eyelid margin, usually most prominent at the opening of the meibomian glands.
Asso with:
seborrheic dermatitis
Allergic conjunctivitis
sym?
conjunctival edema
-> prominent (often with papilla formation)
primarily at the conjunctivae rather than lid margin,
Asso with:
seasonal allergies or other atopic disorders.
TCA overdose
- > anticholinergic effects (eg, hyperthermia, flushed skin, dilated pupils, decreased bowel sounds)
- > seizures
- > cardiac toxicity (eg, prolonged QRS interval, hypotension)
antidopt?
Hypotension is treated with isotonic saline boluses;
refractory hypotension may require vasopressors (eg, norepinephrine)
->IV NaHco3:
decreases the incidence of ventricular arrhythmia
anticholinesterase toxicity
sym?
antidopt?
Atropine and pralidoxime
sym:
- > cholinergic toxicity
-> bradycardia, miosis, and salivation.
Hyperkalemia
-> peaked T waves, followed by lengthening of the PR and QRS intervals, and eventually resulting in a sine wave.
-> Bradycardia and muscle weakness
rx?
Calcium gluconate