IM mix UWQ - may30th 2021 Flashcards

(94 cards)

1
Q

chemotherapy at risk for opportunistic pathogens?

A

gram-negative bacillus Pseudomonas aeruginosa.

-> ecthyma gangrenosum

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2
Q

Pyoderma gangrenosum

sym?

A

neutrophilic dermatosis

-> seen with IBD and arthropathies.

dev rapidly –> begin as a cutaneous papule/nodule–> quickly matures into a painful, purulent ulcer with violaceous borders.

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3
Q

lose weight to achieve and maintain a healthy weight.

rx?

A

each 10 kg (22 lb) of weight loss can lower blood pressure by ~6 mm Hg;

-> weight loss is one of the most effective nonpharmacologic interventions

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4
Q

Pain in the groin, buttock, or lateral hip (trochanteric) region and can radiate to the lower thigh or knee.

  • > mild pain and brief stiffness with prolonged rest <30 mins
  • .> worst pain usually occurs with activity and weight bearing

dx?
XR finding?

A

osteoarthritis of the hip

x-ray:
loss of joint space, osteophyte formation, and subchondral sclerosis.

loc: 
Knees
Hips
DIP joints
1st carpometacarpal joint
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5
Q

Lower back pain

rx?

A

acute <4 weeks: moderate exercise, NSAIDS

subacute/ chronic >12 wks:
exercise rx, TCA, duloxetine

secondary prevention: exercise therapy, education

Vs/ back brace not useful for preventing LBP

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6
Q

high dose drug prolong use>3 month

Constitutional symptoms (eg, fever, malaise)

Arthralgias
Serositis (eg, pleuritis, pericarditis)

Rash (less common compared with SLE)

Dx?
rx induced?

A

Drug-induced lupus erythematosus

procainamide, hydralazine, penicillamine

Others:
minocycline,
TNF-α inhibitors (eg, etanercept, infliximab),
isoniazid

RF: slow acetylator status

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7
Q

Hypertrophic osteoarthropathy

sym?

A
  • > underlying lung disease (eg, adenocarcinoma, chronic pulmonary infection)
  • > arthralgia.
  • > skin thickening and digital clubbing
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8
Q

Microscopic polyangiitis and granulomatosis with polyangiitis
(wegener)

-> necrotizing, small-vessel vasculitides

sym?
lab?

A
  • > acute-onset fever
  • > tracheopulmonary disease.
  • > rhinosinusitis, hematuria, and rash (eg, palpable purpura)
  • > saddle nose , hearing loss
    lab: c-ANCA: PR3+, MPO+
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9
Q

Osteogenesis imperfecta

A

defective formation of type 1 collagen,

  • > bone, tendons, ligaments, skin, teeth, and sclera.
  • > childhood with fragility fractures, short stature, impaired hearing, blue sclera
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10
Q

osteomalacia

-> fatigue, bone pain, and hypophosphatemia

lab?

Asso with: celiac dx, CKD, Chronic liver dx, bypass surgery

A
↑ Alkaline phosphatase
↑ PTH
↓ Serum calcium & phosphorus
↓ urinary calcium
↓ 25 OH-D levels

X-rays: thinning of cortex with reduced bone density

-> reduced mineralization of the osteoid matrix

Bilateral & symmetric pseudofractures (Looser zones)

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11
Q

amiloride

moa?
sym?
rx?

A

potassium-sparing diuretic that blocks the epithelial sodium channel (ENaC) in the renal collecting system.

sym:
hyperkalemia
met acidosis

rx: switch rx -> CCB recheck in 1-2 wks

severe hyperkalemia rx:
IV ca + insulin + glc

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12
Q

Goodpasture syndrome)

sym?
hx?

A

hx:
anti–glomerular basement membrane (anti-GBM) disease

renal bx: formation of antibodies to the alpha-3 chain of type IV collagen

-> linear IgG deposition along the glomerular basement membrane IF

sym:
1. renal : pnuria <3.5g/day, hematuria
2. resp: hemoptysis , SOB

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13
Q

PCP

sym?

A

HIV patients with CD4 counts <200/mm3.

  • > Fever, dyspnea, and nonproductive cough
  • > Fatigue, weight loss, and chills
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14
Q

acute-onset, severe headache

vomiting, photophobia, neck stiffness, and lethargy

dx?

Rx?

A
subarachnoid hemorrhage (SAH) 
-> ruptured saccular aneurysm
isolated CN palsies -> sign of a compressing aneurysm:
Oculomotor nerve (CN III) palsy
->  pupillary dilation:  loss of PNS,  ptosis and down and out due to loss of somatic innervation.

Full or partial oculomotor nerve palsy: enlarging or ruptured aneurysm of the adjacent PCA

Dx: CT angiography

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15
Q

Cavernous sinus thrombosis

sym?

A

fever, headache, and periorbital swelling.

-> palsy of ICA, CNs III, IV, and VI , V1, v2 resulting in ophthalmoplegia.

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16
Q

JC virus reactivation
untreated AIDS

dx?

A

Progressive multifocal leukoencephalopathy

MRI:
asymmetric white matter lesions;
no enhancement/ edema

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17
Q

Community acquired pneumonia (CAP)

  • > pulmonary parenchymal infection, focal consolidation
    sym: develop acutely and include fever, cough, pleuritic chest pain, and dyspnea.
  • > Tachycardia, tachypnea, focal crackles (right lower lobe)

dx?

A

> caused by bacterial (majority), viral (30%), or fungal pathogens.

-> strep pneumonia

dx: CXR
- > Symptomatic treatment alone insufficient due to the risk of secondary bacterial pneumonia

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18
Q

chronic pancreatitis

CT: pancreatic atrophy and calcifications

RF: smoking + Etho

rx?

A

destruction of acinar and islet cells
-> pancreatic exocrine insufficiency.

Pancreatic secretion is stimulated by cholecystokinin (CCK).

Normally, pancreatic enzymes breakdown CCK-releasing protein, thereby limiting CCK release.

pancreatic insufficiency, pancreatic enzyme deficiency

  • > release of high volumes of CCK
  • > pancreatic hyperstimulation

rx:
Pancreatic enzyme supplementation, lipase, protease, and amylase

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19
Q

obstructed pancreatic duct

dx?

A

Endoscopic retrograde cholangiopancreatography (ERCP) with sphincterotomy and/or stent placement

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20
Q

burning or itching of the lids, discharge (which may be associated with crusting of the eyelashes in the morning),

  • > often a foreign body sensation in the eye
  • > scaling at the lid margin

Dx?

A

Blepharitis

-> inflammation at the eyelid margin, usually most prominent at the opening of the meibomian glands.

Asso with:
seborrheic dermatitis

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21
Q

Allergic conjunctivitis

sym?

A

conjunctival edema

-> prominent (often with papilla formation)

primarily at the conjunctivae rather than lid margin,

Asso with:
seasonal allergies or other atopic disorders.

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22
Q

TCA overdose

  • > anticholinergic effects (eg, hyperthermia, flushed skin, dilated pupils, decreased bowel sounds)
  • > seizures
  • > cardiac toxicity (eg, prolonged QRS interval, hypotension)

antidopt?

A

Hypotension is treated with isotonic saline boluses;
refractory hypotension may require vasopressors (eg, norepinephrine)

->IV NaHco3:
decreases the incidence of ventricular arrhythmia

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23
Q

anticholinesterase toxicity

sym?
antidopt?

A

Atropine and pralidoxime

sym:
- > cholinergic toxicity

-> bradycardia, miosis, and salivation.

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24
Q

Hyperkalemia
-> peaked T waves, followed by lengthening of the PR and QRS intervals, and eventually resulting in a sine wave.

-> Bradycardia and muscle weakness

rx?

A

Calcium gluconate

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25
Systemic sclerosis: severe hypertension and acute renal failure -> scleroderma renal crisis Thrombocytopenia and microangiopathic hemolytic anemia rx?
renal ischemia -> activation of the renin-angiotensin-aldosterone system (RAAS). rx: ACEi elevated serum creatinine level is not a contraindication for ACE inhibitors Hemodialysis -> Urgent indications hyperkalemia, volume overload with respiratory impairment
26
multiple sclerosis -> neurologic symptoms (eg, weakness, incontinence) rx?
interferon beta-1a
27
MDD -> anhedonia, feelings of worthlessness, weight loss, low energy, impaired ability to think) accompanied by memory impairment rx?
depression-related cognitive impairment rx: - > selective serotonin reuptake inhibitors (eg, escitalopram) -> psychotherapy.
28
AD rx?
- > Cholinesterase inhibitors (eg, donepezil) - > NMDA receptor antagonist memantine treatment of dementia (eg, Alzheimer disease)
29
-> congenital narrowing of the descending aorta, just distal to the left subclavian artery. creates a proximal arterial pressure load affecting the upper body dx?
Coarctation of the aorta - > Congenital - > Acquired (rare) (eg, Takayasu arteritis) - > hypertension - > continuous murmur - > S4 CXR: notching of the posterior third of the third to eighth ribs -> bony erosion due to enlarged intercostal arteries.
30
Upturning of the cardiac apex ("boot-shaped heart") dx?
tetralogy of Fallot due to pulmonic stenosis and consequent right ventricular hypertrophy.
31
Diffuse vascular calcifications dx?
premature ATS with advance renal failure
32
Prominent right atrial contour dx?
Ebstein congenital abnormality -> apical displacement of the tricuspid valve with atrialization of the right ventricle
33
MM -> back pain, normocytic anemia, and arm pain Hx? dx?
Osteolytic lucent lesion Dx: serum pn electrophoresis , M spike bone marrow biopsy confirm
34
warning signs consideration of early imaging: 1. Neurologic findings: Seizure, changes in consciousness, specific deficits 2. Differences compared to prior headaches: Change in frequency, intensity, characteristics 3. Other: New at age >40, sudden onset, trauma, present on awakening Dx?
Dx: MRI
35
- > lymphoplasmocytic malignancy - > excessive production of monoclonal IgM antibody. sym: - > hyperviscosity syndrome (diplopia, tinnitus, headache, dilated/segmented funduscopic findings), -> neuropathy (electric sensation), infiltrative disease (hepatosplenomegaly, anemia, thrombocytopenia) dx?
Waldenstrom macroglobulinemia (WM dx: monoclonal spike (M-spike) of IgM - > bone marrow biopsy showing >10% clonal B cells
36
Multiple myeloma (MM) lab?
monoclonal IgG, IgA, or light chains -> CRAB bone pain
37
Psoriatic arthritis (PsA) sym? X-ray: narrowing of the proximal phalanx with erosion of the distal phalanx (pencil-in-cup deformity) and new bone formation
cyclical/episodic --> rather than chronic/slowly progressive. - > Prolonged (>30 min) morning stiffness and pain lessen, not worsen, with activity. - > involves the DIP and PIP joints;
38
AR RF? sym? Backflow from aorta into LV → ↑ LV end-diastolic volume LV initially compensates with eccentric hypertrophy → ↑ SV & CO --> bring ventricular closer to chest wall -> pounding snesation and pounding in left decubitus position Eventual LV dysfunction → ↓ SV & CO → heart failure
1. Congenital bicuspid aortic valve Postinflammatory (eg, rheumatic heart disease, endocarditis) 2. Aortic root dilation (eg, Marfan syndrome, syphilis) sym: Decrescendo diastolic murmur Widened pulse pressure (↑SBP & ↓DBP) Rapid rise-rapid fall (“water-hammer”) pulsation Abrupt carotid distension & collapse, “pistol-shot” femoral pulses
39
constrictive pericarditis sym? dx? ``` etio: idiopathic viral pericarditis (>40%) radiation therapy (~30%) cardiac surgery (~10%) connective tissue disorders ``` eg. TB
impairs ventricular filling during diastole, - > decreased cardiac output (fatigue and dyspnea on exertion) - > venous overload (elevated JVP, ascites, and pedal edema). - > Kussmaul's sign, lack of the typical inspiratory decline in central venous pressure, pericardial knock (early heart sound after S2) - > Sharp x and y descents on central venous tracing. Pericardial calcification
40
normal thyroid function with an estrogen-induced lab?
-> increase in T4-binding globulin (TBG), transthyretin, and albumin. increase the level of TBG by decreasing its catabolism and increasing its synthesis in the liver. - > more TBG binds more TH - > TH production inc to maintain a euthyroid state; - > slight elevation in total T4 level Only the free (ie, unbound) thyroid hormones are biologically active
41
ankylosing spondylitis (AS) Rx?
Nonpharmacologic measures: Exercise (postural exercises, ROM/stretching exercises) Physical therapy Initial treatment: 1. NSAIDs (eg, ibuprofen, naproxen) 2. COX-2 inhibitors (eg, celecoxib) Rx fails: 1. TNF-α inhibitors (eg, etanercept, infliximab) 2. Anti–IL-17 antibodies (eg, secukinumab)
42
prevent rejection in patients with allogeneic transplants rx?
Mycophenolate
43
cluster headaches rx?
100% o2 + sumatriptan
44
hereditary hemochromatosis sym? rx? elevated iron studies. Diagnosis: genetic analysis of HFE mutations
- > hepatic fibrosis and cirrhosis - > skin pigmentation (sun-exposed areas, scars, genitalia), - > diabetes mellitus ("bronze diabetes"), - > arthropathy - > hypogonadism (diminished libido, erectile dysfunction [ED]) Serial phlebotomy to deplete excess iron stores -> reduce the risk for cirrhosis and HCC.
45
Hemolytic anemia due to intravascular erythrocyte trauma lab?
schistocytes or helmet cells Intravascular erythrocyte destruction-> free hemoglobin in the serum (hemoglobinemia) + urine (hemoglobinuria) -> increased serum lactate dehydrogenase Haptoglobin is a serum protein that binds free hemoglobin -> excess amount of free hemoglobin in the serum decreasing the level of haptoglobin
46
deep venous thrombosis (DVT) wells score? dx? rx?
Patients with a score ≥2 (eg, pitting edema, calf swelling >3 cm compared to the other leg) more likely to have DVT dx: compression ultrasonography rx: anticoagulation
47
Medications for osteoporosis?
1. Bisphosphonates (eg, alendronate, risedronate) -> First-line treatment for most patients ``` 2. Selective estrogen receptor modulators (eg, raloxifene) -> Less effective -> May lower risk of breast cancer -> Increased risk of DVT, hot flashes, endometrial ca, uterine sacroma ```
48
Rx induce EPS ? sym? moa? rx?
metoclopramide prochlorperazine moa: DA antagonist sym: EPS : ADAPT acute dystonia -> muscle spasm/ stiffness , oculogyric crisis, laryngeal dystonia akathisia parkinsonism tartive dyskinesia rx: benzotropine (antiAch rx) / diphenhydramine
49
aprepitant moa?
sub P NK1 receptor antagonist
50
self induce vomiting diuretics overuse lab?
Loss HCl- hypochloremic met alkalosis ph>7.45 hco3 >24 low urine chloride < 20
51
persistent diarrhea RTA lab?
severe hypokalemia ``` low Ph ( met acidosis) low Hco3 non-AG met acidosis ```
52
MC community-acquired bacterial meningitis?` dx? rx?
Streptococcus pneumoniae dx: Blood cultures + lumbar puncture. Rx: - > third-generation cephalosporin (eg, ceftriaxone), -> vancomycin, - > dexamethasone (to reduce inflammatory morbidity)
53
atelectasis BS? percussion? tactile fremitus?
-> BS: dec -> percussion: dull -> tactile: dec mesiastinal shift: towards
54
Bacterial pneumonia BS? percussion? tactile?
BS: inc percussion: dull tactile: inc mediastinal shift: none
55
Lymphoma / sarcoidosis sym?
-> bilateral hilar lymphadenopathy
56
Raising the cut-off point ? sens? spec?
increasing the inclusion criteria) of a screening test: - > increase in specificity (SpIN) - -> TN/TN+ FP - > decrease in sensitivity (SnOUT) - -> TP/TP+FN - -> higher cut off pt : dec TP, dec FP ** TP close to =1 FP : 1- specificity =
57
Bells pasly, unilateral facial paralysis sym? rx? dx?
sym: - > acute (over the course of hours) and progressive - > within 3 weeks. - > auricular pain or dysacusis (distortion of sound) rx: - > prednisone - > corneal protection strategies dx: NOT needed if classic presentation!!!
58
pre-renal azotemia ( renal hypoperfusion) lab?
inc BUN/Cr > 20:1 inc Urea absorption -> systemic hypovolemia / impaired CO
59
erectile dysfunction rx?
PDE-5 inhibitor ( sildenafil) etio: CVD ** not remove current medication
60
Pneumothroax etio? sym?
PEEP vent: alveolar damage, pneumothroax, hypotension --> sudden SOB, tachycardia, hypotension, tracheal deviation -> unilateral absence BS, impaired ventricular filing
61
Atelectasis sym?
cough , dyspnea dec PaO2 stats -> NO hypotension cuz not compression mediastinum
62
pul embolism sym?
sudden-onset SOB , tachypnea, hypoxia, hypotension
63
cardiac tamponade sym?
beck's traid: hypotension, elev CVP, muffled heart sound etio: build up of fluid around heart compressing ** NOt have unilateral absence BS
64
high output HF sym?
- > dec SVR --> inc CO - > brisk ocarotid upstroke - > widened pulse pressure etio: 1. bypass SVR -> AV fistula 2. inc peripheral vessels -> morbid obesity (MC); paget dx 3. vasodilation unmet metabloism demands in tix -> hyperthyroidism, sever anemia, thiamine def sym: - > eccentric LVH -> inc VR + venous hydrostatic pressure inc - > peripheral edema - > pul edema
65
Dual antiplatelet therapy moa?
DAPT with ASA -> P2y12 receptor blockers : clopifogrel, prasugrel , ticagrelor additional rx: - > beta blockers - > ACEI - > statins - > aldosterone antagonist
66
apixaban mao?
FXa inhibitor rx: DVT + PE
67
chlorpheniramines moa? asso with allergic rhinitis
postnasal drip, asthma, GERD induce --> chronic cough >8 wks moa: reduce H1 receptors --> blocking histmine relase mast cells --> blocking nasal secretion ** inhaled corticosteroids: dec airway inflammation
68
mucosal neuroma risk for?
MEN2B -medullary thyroid ca - pheochromocytoma - marfanoid habitus mucosal neuroma
69
Tuberous sclerosis sym?
HARMOTOMS - > seizures - > ash-leaf sopts - > facial angiofibromas - > shagren patches
70
hereditary hemorrhagic telangiectasis ( osler weber rendu syn) sym?
- > AVM - > massive hemoptysis, GI bleeding - > mucosal telangiectasias
71
acute otitis externa etio? moa? sym? rx?
"swimmers ear" -> water exposure -> trauma foreign bodies ( earbuds, hearing aid) etio: pseduomonas , s. aureus sym: - > otalgia, pruritus, discharge, hearing loss - > pain with auricle manipulation - > ear canal erythema, edema, debris rx: topical fluroquinolone
72
otitis media with effusion sym?
ear pain + fullness -> drainage in presence TM perforation -> less common
73
osmotic / sevretory diarrhea stool osm gap? moa? lab?
osmotic diarrhea: moa: nonabsorbed Osm active solute - > polyethylene glycol, sorbitol, lactose - > inhibits water resorption - -> SOG > 125 lab: SOG = 290 - 2 x (stool Na + stool K) <50 secretory diarrhea -> toxin ( v. cloria , hormones, CF, bile acid, postsurgical bowel resection) --> persistent while fasting at night 50-125 indetermin >125 Osmotic diarrhea ( lactose intolerance) --> after ingestion
74
SIADH Sq call Ca ( inc ADH) lab? rx?
inc ADH --> inc water reabsorption - > high Urine Na - > low renin, low aldo -> euvolemic hyponatremia ( diluted by excess water reabsorption) lab: - > serum osm < 290 ( diluted by water) - > urine Osm >100 ( more concentrated ) - > high urine Na >25 (concentrated with water all reabsorbed) rx: - > fluid restriction - > hypertonic saline (3%) -> careful infusion - -> <8 mEq/L over 24 hours avoid Osmotic demyelination syn
75
DI central lab? rx?
low ADH -> losing water - > low ADH - > low urine Na ( diluted urine with excess water) - > polyuria, polydypsia rx: desmopressin ( ADH analong)
76
BZD se?
occur within a hour after ingestion: paradoxical agitation -> in elderly -> taper off
77
PEEP effects? decomp LHF with cardiogenic pul edema - S3, crackles, hypoxemia
PEEP effects: 5-20cm H2O - > inc Intrathoracic pressure -> drop in VR to RH - -> dec RV preload ( dec CVP) - -> inc RV afterload (PCP) compresses alveolar capillaries - -> dec LV preload (less blood voln returning to LA) - -> dec MAP thru baroreceptor effects by lowering adrenergic tone-> dec neurohormonal activation - -> dec LV transmural pressure - -> dec LV afterload - -> inc PaO2, LV performance, CO - -> inc end-organ O2 delivery + survival
78
primary polydipsia lab?
etio: schizo, excess water intake excess hypoNa -> excess ADH secretion hyponatremia and dilute urine with urine osmolality <100 mOsm/kg. significant hyponatremia can develop confusion, lethargy, psychosis, and seizures
79
MDD with psychotic features sym? rx?
MDD in which the patient develops psychotic symptoms during a depressive episode. rx: - > combined antidepressant and antipsychotic - > electroconvulsive therapy - -> faster response in elderly patients unable to eat/ dink with suicidal thoughts
80
Persistent complex bereavement disorder (complicated grief) sym?
intense yearning for the deceased that persists for at least 6 months to a year after the loss. -> It is not associated with psychotic features.
81
Spironolactone and eplerenone
mineralocorticoid receptor antagonists (MRAs)
82
chi-square test testing?
relationship between 2 categorical variables. --> qualitative (gps/ categories) - >categorical INdependent variable (eg, exposure or intervention) - > 2 groups and a categorical dependent variable (eg, outcome).
83
Two-sample t-test
- > Compares the MEAN of a quantitative variable of 2 independent groups - -> quantitative ( # value ) eg. comparing serum ferritin concentrations (ie, quantitative variable) in male and female patients ( qualitative -gps)
84
correlation analysis testing?
- > correlation coefficient to describe the LINEAR relationship between 2 quantitative variables - > evaluating the linear relationship between stress level and irritability score
85
Exercise-associated postural hypotension sym? moa?
- > sudden decrease in VR after cessation of exercise, which fails to meet increased cardiac demand. - > collapse (with no loss of consciousness) immediately after completion of exercise.
86
Exertional hyponatremia sym?
- > excessive fluid intake (weight gain). - > confusion, headache, and swollen hands after prolonged heat exposure - > seizure, collapse.
87
Phencyclidine intoxication sym?
- > psychosis in addition to combative behavior - >delirium: hallucinating immediately - >dissociative symptoms, - > ataxia - > nystagmus
88
Alcoholic hallucinosis sym? time frame?
Visual, auditory, or tactile; intact orientation; stable vital signs time: 12-48 hrs rx: BZD
89
Delirium tremens sym? time frame?
- > Confusion, agitation, fever, tachycardia, hypertension, diaphoresis, hallucinations time: 48-96 hr
90
Acute bacterial prostatitis sym? dx? rx?
sym: - > perineal pain: Lower UTI - > systemic symptoms (eg, fever, chills, acute illness), - > tender, swollen prostate on digital rectal examination dx: U/C rx: 6 wks of AB (eg, trimethoprim-sulfamethoxazole, fluoroquinolone
91
Roux-en-Y gastric bypass complication sym? dx? rx?
- > stomal (anastomotic) stenosis - > progressive narrowing of the GJ anastomosis that leads to obstruction of gastric pouch outflow. dx: - > esophagogastroduodenoscopy (EGD), - > balloon dilation can be performed to open the narrowing.
92
Acute nitrofurantoin-induced pulmonary injury sym?
-> hypersensitivity that can present with fevers, shortness of breath, dry cough, and erythematous rash -> begin 3-9 days from medication initiation XR: bil basilar opacities, pleural effusion (unilateral)
93
AIN sym?
fever, eosinophilia -> nonsp sym , n/v
94
RCC sym?
- > ASX - > flank pain, hematuria, abd renal mass - > varioceles fails to emply -> tumor ob gonadal vein - > inc EPO: polycythemia asso with anemia dx: - > abd CT scan