Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

UWORLD-STEP2 (BA) > IM-MSK > Flashcards

IM-MSK Flashcards

(65 cards)

Start Studying
1
Q

The non-specific antibody marker for SLE?

A

ANA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

The 2 specific antibody marker for SLE

A

Anti-dsDNA & anti-smith

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Chronic malabsorptive diarrhea, wt loss, migratory non-deforming arthritis, lymphadenopathy and a low-grade fever? Dx? and diagnostic test

A

Whipple disease

PAS- + macrophages (Tropheryma whippeli-gram + bacillus)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

dry mouth and eye, lymphocytic infiltration of the salivary glands. Dx? Diagnostic test

A
  • Sjogren syndrome

- SSA (Ro) and SSB (La) antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q 
Morning facial puffiness and bilateral leg swelling. Recurrent pulmonary infection, psoriasis, 4+ proteinuria . 
Dx? 
diagnostic test? 
Tx? 
Prevention?
A

Amyloidosis
Abdominal fat pad aspiration biopsy
Colchicine for tx and prevention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Serology finding for systemic sclerosis (4)

A
  • Antinuclear antibody (ANA)
  • Anti-topoisomerase I (anti-scl-70)antibody
  • Anti-RNA polymerase III
  • Anti-centromere antibody
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Med risk for tendon rupture (Achilles)

A

Fluoroquinolone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Associated findings for Anklosing spondylitis (3)

A
  • thoracic wedging
  • hyperkyphosis
  • Aortic regurgitation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
  • Groin pain on weight bearing
  • Pain on hip abduction and internal rotation
  • no erythema, swelling, or point tenderness
A

Avascular necrosis of the hip

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

The 2 carpal tunnel syndrome tests

A
  • Phalen

- Tinel tests

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The 3 treatments for Carpal tunnel syndrome

A
  • Wrist splinting
  • Glucocorticoid injection
  • Surgery
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are associated condition with Primary Raynaud’s phenomenon?

A

No underlying cause

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are associated conditions with Secondary Raynaud’s phenomenon (6)?

A
  • Connective tissue disease (Scleroderma)
  • Occlusive vascular conditions (SLE, thromboangiits obliterans)
  • Sympathomimetic drugs
  • Vibrating tools
  • Hyperviscosity syndromes
  • Nicotine
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Pt with rheumatoid arthritis, came in with Macrocytic anemia, nausea, stomatitis, rash, hepatotoxicity, interstitial lung disease, alopecia and fever

A

Methotrexate SE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

45-54YO. Hx of repetitive or forceful wrist extension, pain in lateral elbow.
Pain with resisted wrist extension or supination
Pain with passive wrist flexion

A

Lateral epicondylitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tx of lateral epichondylitis (5)

A
  • Modiefied activity
  • inelastic counterforce brace
  • NSAID
  • Stretching and progressive resistance exercise
  • PT
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

The two nodes on osteoarthritis hand

A
  • Proximal interphalangeal (Bouchard nodes)

- Distal interphalangeal (Heberden nodes)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

common causes of overproduction of uric acid other than gout include (5)

A
  • hematologic malignancies
  • Myeloproliferative/lymphoproliferative sidorders
  • Tumor lysis syndrome
  • Psoriasis
  • Hypoxanthine-guanine phosphoribosyl transferase (HGPT) deficinecy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

what nodules locations are presented in Rheumatoid

A

elbows (commonly)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What spinal risk is involved in Rheumatoid?

A

cervical joint- spine subluxation-spinal cord compression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

> 3 months of symptoms with widespread pain index or symptom severity score. Normal laboratory studies

A

Fibromyalgia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Proximal muscle weakness (difficulty climbing upstairs), pain mild/absent

A

Polymyositis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

diagnostic for Polymyositis (3)

A
  • Elevated muscle enzymes (CK, aldolase, AST)
  • Autoantibodies (ANA, anti-Jo-1)
  • Biopsy- Endomysial infiltrate, patchy necrosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

50yo, stiffness in pain in shoulders, hip girdle, neck. Associated with giant cell (Temporal)arteritis

A

Polymyalgia rheumatica

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Diagnostic for Polymyalgia rheumatica (2)
- Elevated ESR, C-reactive protein | - Rapid improvement with glucocorticoids
26
Purulent monoarthritis &/OR | Triad of Tenosynovitis, dermatitis, asymmetric migratory polyarthralgias
Disseminated gonococcal infection
27
How to diagnose Disseminated gonococcal infection (3)
- Blood culture (maybe neg) - Synovial fluid analysis: Inflammatory effusion with neutrophil predominance (gram stain & culture or NAAT) - Culture or NAAT of urethra, cervix, pharynx, rectum
28
Tx: Disseminated gonococcal infection
- IV ceftriaxone-> switch to oral (Cefixime) when clinically improved - empiric azithromycin OR doxycycline for concomitant chlamydial infection - Joint drainage for purulent arthritis
29
progression of tx for RA includes
1. Methotrexate 2. add TNF inhibitor with parallel therapy - an addition of Sulfasalazine, hydroxychloroquine) 3. Switch to alternate TNF inhibitor and continue Methotrexate
30
Extrusion of fluid from knee joint space into semimembranosus/gastrocnemius bursa
Popliteal (Baker) cyst
31
Joint pain worst in the morning, Morning stiffness >60mins?
RA
32
Joint pain worst in the evening and morning stiffness <30seconds
OA
33
Limited range of motion with crepitus and pain
OA
34
Positive anti-CCP diagnostic test for?
RA
35
X-ray with soft-tissue swelling, joint space narrowing, and bony erosions
RA
36
Why is osteoporosis risk for RA(4)?
- increased level of proinflammatory cytokines - corticosteroid therapy - lack of activity - generalized loss of bone mass in RA
37
Posture-dependent pain-lumbar extension worsens pain and lumbar flexion relieves pain, lower extremity numbness, and tingling, lower-extremity weakness, low back pain -Normal pulses and frequently normal examination
Neurogenic claudication (pseudoclaudication)
38
Diagnosis: Neurogenic claudication (pseudoclaudication)
MRI of spine
39
Common reason for lumbar spinal stenosis
- degenerative arthritis (Spondylosis) - Degenerative disk disease - Thickening of the ligamentum flavum
40
``` Exertionally dependent pain Pain relieved with rest LE cramping/tightness NO LE weakness Possible buttock, thigh, calf or foot pain ```
Vascular claudication | -Decreased pulses, cold extremities, decreased hair growth, pallor with leg elevation
41
Dx: vascular claudication
ABI
42
New mom holding her baby with thumb stretched causing wrist pain
De Quervain tenosynovitis
43
De Quervain tenosynovitis:- which two tendons are affected
- Abductor pollicis longus | - Extensor pollicis brevis
44
a non-modifiable risk for osteoarthritis (5)
- Advanced age - Female - Family Hx - Abnormal joint alignment - prior joint trauma
45
Modifiable OA risks (4)
- Sedentary lifestyle - Obesity - Occupational joint loading - DM
46
``` Arthritis (sacroiliitis) Reduced chest expansion & spinal mobility enthesitis Dactylitis Uveitis ```
Ankylosing spondylitis
47
3 risk of Ankylosing spondylitis
- Osteoporosis/vertebral fractures - Aortic regurgitation - cauda equina
48
Ddx of anterior knee pain in young patients (3)
- Patellofemoral syndrome - Patellar tendonitis - Osgood-Schlatter disease
49
A young female athlete with subacute to chronic pain that increased with squatting, running, prolonged sitting, using stairs
Patellofemoral syndrome
50
Patellofemoral syndrome, diagnostic
Patellofemoral compression test
51
Primary athlete (jumper's knee), with episodic pain and tenderness at the inferior patella
Patellar tendonitis
52
Preadolescent/adolescent athletes with a recent growth spurt | with increasing pain with sports, relieved by rest, tenderness and swelling at the tibial tubercle
Osgood-Schlatter disease
53
Risk factors for carpal tunnel syndrome (5)
- working on a computer for long hrs - Obesity - DM - Pregnancy - Hypothyroidism
54
Medial knee pain and tenderness
Pes anserinus pain syndrome (PAPS)
55
Pes ansernus is formed by the conjoint tendons from which 3 muscles
- Gracilis - Sartorius - Semitendinosus
56
low back pain, increased with standing, walking. lying on back, tenderness at the affected level, negative leg raised test
Vertebral compression fracture- risk from Osteoporosis
57
45% of patient have complicated inflammatory bowel disease by
arthritis (involve axial or peripheral joints)
58
Skin manifestation of hereditary hemochromatosis
Hyperpigmentation (bronze diabetes)
59
MSK manifestation of hereditary hemochromatosis (3)
Arthralgia arthropathy chondrocalcinosis
60
GI manifestation of hereditary hemochromatosis (3)
- Elevated hepatic enzymes with hepatomegaly (early) - Cirrhosis (later) - Increased risk of hepatocellular carcinoma
61
The endocrine manifestation of hereditary hemochromatosis (3)
DM secondary hypogonadism hypothyroidism
62
Cardiac manifestation of hereditary hemochromatosis (2)
restrictive or dilated cardiomyopathy | conduction abnormalities
63
Infections manifestation of hereditary hemochromatosis
Increased susceptibility to listeria, Vibrio & Yersinia enterocolitica
64
What are the iron studies that are abnormal in hereditary hemochromatosis (3)
High serum Iron, | Ferritin and transferrin saturation
65
Rheumatoid arthritis Low WBC Large spleen Often serious and repeated infections
Felty's syndrome

UWORLD-STEP2 (BA) (19 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions