IM Rheumatology Flashcards
Definition of rheumatoid arthritis
Autoimmune, inflammation of synovial joints
Etiology of rheumatoid arthritis
T cells release cytokines
Makes a pannus
R Factor and anti - ccp antibodies
Genetic: HLA DR1,4
Symptoms of Rheumatoid arthritis
Fever, WL, anaemia
Nodules
Bone deformations (PIP, MCP, MTP)
Pleural effusion, fibrosis
Atherosclerosis
Diagnosis of rheumatoid arthritis
> 6 weeks
Pain and stiffness in morning for >1hour
Inc RFactor and anti-CCP
Swelling (not osteoarthritis)
Treatment of rheumatoid arthritis
DMARDS
Biologics
NSAIDS
Glucocorticoids
Definition of ankylosing spondylitis
- autoimmune
- no RF
- affects vertebral discs and facet joints
Etiology of Ankolysing spondylitis
HLA B27 gene
Joints replaced with fibrin that causes ossification of spinal cord - syndesmophytes
Can lead to anterior uteris, entheris, aortic regurgitation
Symptoms of ankylysing spondylitis
WL, fever, malaise
Bum and joint pain
SOB
Diagnosis of ankylosising spondylitis
MRI
X ray shows bamboo spine
Gene
Treatment of ankylosising spondylitis
NSAIDS
Exercise
DMARDS
Biologics
Surgery if bad
Reactive arthritis definition
Joint inflammation after infection
Std or GI
No RF
Etiology of reactive arthritis
HLA B27
2-3 weeks after infection
Triad - urethra, conjunctivitis, joints
Symptoms of reactive arthritis
Entheris
Pain and swelling in joints
Keratoderma blerro. (Rash on feet)
Diagnosis of reactive arthritis
Synovial fluid analysis
RF
Infection and clinical exam
Serum
Treatment of reactive arthritis
NSAIDS
DMARDS OR AB
Or steroids
