Images - Smears, skin, etc

Question 1

Identify the abnormality (2) and diagnosis

Answer 1

Hereditary Elliptocytosis - numerous elliptocytes and smaller numbers of ovalocytes.

Question 2

Identify the abnormality (1) and diagnosis

Answer 2

Microangiopathic Hemolytic Anemia - from cyclosporine therapy, with numerous red-cell fragments.

Question 3

Identify the abnormality (1) and diagnosis

Answer 3

Acute Hemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency, with the
presence of a “bite” cells

Question 4

Identify the abnormality (1) and diagnosis

Answer 4

Acute Hemolysis in G6PD deficiency, with two “blister
cells” (arrows), as well as polychromatic macrocytes and irregularly contracted cells

Question 5

Identify the abnormality (1) and diagnosis

Answer 5

Hereditary Spherocytosis - numerous spherocytes (hyperchromatic cells with a regular outline)

Question 6

Identify the abnormality (3) and diagnosis

Answer 6

Pernicious Anemia - anisocytosis, macrocytosis, and a hypersegmented neutrophil.

Question 7

Identify the abnormality (2) and diagnosis

Answer 7

Myelodysplastic Syndrome - blast cell and two neutrophils that have hypolobulated nuclei, one of which is binucleated and the other hypogranular

Question 8

Identify the abnormality (5) and diagnosis

Answer 8

Myelodysplastic Syndrome

1. Anisocytosis
2. Poikilocytosis
3. Macrocytes
4. Stomatocytes
5. RBC with Pappenheimer bodies

Question 9

Identify the abnormality and provide differential diagnosis

Answer 9

Baso BAsoBBasfBaso BAsoBasophilic Stippling:

1. Sideroblastic Anemia
2. Arsenic Poisoning
3. Lead Poisoning (with microcytic anemia)
4. Thalassemias

**Mnemonic = Peppered with SALT

Question 10

Identify Two Abnormal Cells

Answer 10

1. Nucleated Red Cell
2. Sickle Cell

Question 11

What is the abnormality?

Answer 11

Platelet clumping - leads to artificially low platelet count

Question 12

What is the abnormality?

Answer 12

Cryoglobulinemia in patient with HCV

Question 13

Identify three abnormalities and provide the diagnosis

Answer 13

1. Target Cell
2. Howell-Jolly Body
3. Acanthocyte

Dx: Hyposplenism

Question 14

What is the lesion and what is the differential (3 and 2)?

Answer 14

1 1. alq. 111. 1. 1. Erythema Multiforme

2. Drugs: PCN, Dilantin, Sulfa

Infections: HSV, mycoplasma

Question 15

1. What is the lesion and what are its features?
2. Where does it usually occur?
3. Etiologies (4)?

Answer 15

1. Lichen Planus - purple, puritic, planar, polygonal, papules
2. Wrists and ankles along lines of prior trauma
3. HCV, HCTZ, ACEI, sulfonylureas

Question 16

1. What is the lesion and what are its features?
2. Etiology (6)?

Answer 16

1. Fixed Drug Eruption - Circular red-purple lesions with sharp borders
2. PCN, tetracyclines, dilantin, sulfonadmides, barbituates, phenolthalein

Question 17

1. What is the lesion and what are its features?
2. Etiology (3)?

Answer 17

1. Pityriasis Rosea - large “herald” patch, salmon-colored oval lesions with fine scale
2. a. Secondary Syphilis
   b. Drug eruption
   c. Tinea

Question 18

1. What is the lesion and what are its features?
2. Etiology (1)
3. Treatment (4)

Answer 18

1. Tinea Versicolor - round red-to-coffee colored lesions on back/chest/neck that are hypopigmented when exposed to sun
2. Malassezia Furfur - KOH with spores and hyphae in a “spaghetti and meatball” pattern
3. a. Selenium sulfide 2.5% lotion
   b. Ketoconazole shampoo
   c. Imidazole or triazole creams
   d. Ketoconazole 400 mg

Question 19

1. What is the lesion and what are its features?
2. Treatment

Answer 19

1. Tinea Corporis - annular patch with scaly pink edges
2. Topical antifungals