Immune Flashcards

(34 cards)

1
Q

Immunomodulators

A

Immunodulator: deep immune stimulation
Facilitate greater immune system flexibility in body’s natural response to disease
Normalizes, modulates and balances the activity of the immune system, up- or down-regulating as needed
Adaptogenic too - Increases resistance, vitality. Adaptation to stress. Adrenal, Endocrine and CNS actions.
Tonifying too – Improves function of organ or system

Astragalus membranaceous (Astragalus)
Codonopsis pilosula (dang shen)
Ganoderma lucidum (Reishi)
Schisandra
Eleutherococcus (Siberian ginseng)

Dr Godfrey argues Echinacea may fit in this category as well as in the immunostimulatory category*

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2
Q

Adaptogen

A

Adaptogen: increase tolerance to stressors: physical, mental and emotional. Many effect the hypothalamus and pituitary; they have far reaching effects - including immune system.
Enhances body’s use of glucose
*Increase glycolysis
*Enhance entry and utilization of glucose w/in cells

Eleutherococcus senticosus (siberian ginseng)
Lentinus edodes (shitake)
Ligustrum lucidum (chastity bush) 
Schisandra chinensis (schisandra)
Ganoderma lucidum (Reishi)
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3
Q

Immunostimulants

A

Immunostimulants: more superficial immune activation; better for short term use and acute conditions.
Nonspecific stimulation or boosting of the immunological defense system without affecting immune system memory cells
Usually antimicrobial as well

Allium sativum (garlic)
Baptisia tinctoria (wild indigo)
Usnea spp (Old Man's Beard)
Echinacea spp
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4
Q

Antihelminthic

A

Juglan nigra (Black Walnut)

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5
Q

Anticancer

A
Larrea tridentata (Charparral)
Ganoderma lucidum (Reishi)
Lentinus edodes (shitake)
Eleutherococcus senticocus (siberian ginseng) = via its adaptogenic properties so maybe its a cheater in this category!
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6
Q

Antifungal

A
Tabebuia spp (Pau D'arco)
Malaleuca spp (Tea tree)
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7
Q

Genito-urinary Herbs

A
Arctostaphylos uva-ursi (bearberry)
Thuja occidentalis (thuja)
Barosma betulina (buchu)
Serenoa repens (saw palmetto)
Zea mays (corn silk)
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8
Q

Allium sativum

A

(Garlic)
ANTIMICROBIAL + ANTIFUNGAL

Conditions: chronic bronchitis, recurrent colds, asthma, ringworm.

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9
Q

Arctostaphylos uva ursi

A

(Bearberry)
ANTIMICROBIAL + DIURETIC + ASTRINGENT

Conditions: UB/KD stones, UTI, chronic KD dx, vaginal infx/ulceration; all GU infx.
Hoffman: PROSTATITIS
Acidic urine - will turn arbutin to hydroquinone and inactivate it.

Dr Gilbert says: GUT affinity

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10
Q

Astragalus membranaceus

A

(Astragalus)
IMMUNOMODULATOR + ADAPTOGENIC

Conditions: Infections, leukopenia (low WBC) assx with steroid use, chemotherapy etc.

Potentiates IL-2 - so do not use with immunosuppressive drugs.
Polysaccharides shown in induce/potentiate phagocytosis + the herb can also restore the bodies depleted red blood cell count.

SAPONINS - active immune molecules in this herb

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11
Q

Barosoma betulina

A

(Buchu)
RENAL ANTISEPTIC + weak DIURETIC

Conditions: cystitis, urethritis, gonorrhea, gout, urgency with no relief. All GU infx.

NOT in acute GI inflammation + Pregnancy

Dr Gilbert says: GUT affinity

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12
Q

Codonopsis pilosa

A

(Dang shen)
IMMUNOMODULATOR + ADAPTOGEN

Conditions: chronic cough, SOB, diarrhea, fatigue, prolaps utuerus/stomach/rectum.

SAPONINS - active immune molecule in this herb

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13
Q

Eleutherococcus senticocus

A

(Siberian ginseng)
ADAPTOGEN

Conditions: angina, HTN, hypotension, chronic bronchitis, CANCER, mild depression, insomnia, RECOVERY FROM SURGERY.

NOT to be used with heart meds, increase Abx, hypoglycemic.

SAPONINS - active immune molecules in this herb

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14
Q

Ganoderma lucidum

A

(Reishi)
ADAPTOGEN + ANTI CANCER + DEEP IMMUNE (immunomodulatory)
antiallergenic/ antibacterial/
hepatoprotective/ antithrombotic

Conditions: allergies, bronchia issues, sinusitis, HTN, atherosclerosis, MI, AIDS, CANCER, hepatitis, high cholesterol.

NOT to be used in organ transplant + autoimmunity.
May cause DARK STOOL

Beta Glucans (a polysaccharide) which give the herb its immune actions!

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15
Q

Juglans nigra

A

(Black Walnut)
ANTIHELMINTHIC + LAXATIVE + ANTIMICROBIAL

Conditions: worms, cold/flu, oral cankers, tonsilitis, ringworm (poultice)

OVERUSE = K+ secretion.

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16
Q

Larrea tridentata

A

(chaparral)
ANTICANCER

Conditions: cancer, bacterial infx, HIV, viruses, parasites, yeast.

NOT: to be used in pregnancy/lactation. Prolonged use = KD/LV toxic d/t LIGNANS.
Banned in some countries due to concerns re.liver,kidneyand lymph toxicity w/ chronic use

17
Q

Lentinus edodes

A

(Shitake)
ANTICANCER + ADAPTOGEN + IMMUNOMODULATOR + ANTIBACTERIAL/VIRAL

Conditions: increased survival time in cancer, advanced cancer, influenza + colds, poor stamina/circulation.

18
Q

Ligustrum lucidum

A

(Chastity bush)
ADAPTOGEN + LV/KI TONIC + IMMUNOSTIMULANT (ANTI bact/viral)

Conditions: prevent bone marrow loss in chemo, neutropenia, HTN, parkinsons, high cholesterol, hepatitis, common cold.

19
Q

Malaleuca spp

A

(Tea tree)
ANTIMICROBIAL + ANTIFUNGAL

Conditions: athletes foot, ringworm, warts, infective rashes, acne, vaginal yeast infx.

TOXIC internally - volatile oil

20
Q

Schisandra chinensis

Godfrey

A

(Schisandra)
ADAPTOGEN + TONIFY Hrt/KD/LU YIN + MIND TONIC + SEXUAL TONIC + ANTITUSSIVE

Conditions: depression, forgetfulness, cirrhosis, cough, SOB.

NOT to be used in pregnancy; may cause heartburn.

Dr. Gilbert Notes
Energetics: warm, stillness
Const:lignans
Actions: adaptogen
TCM: collects and retains fluids (LU,KI,HT)
Secondary: sexual tonic, hepatoprotective, astringent, antitussive, expectorant
Cautions: don’t use with full heat or new
cough
Seed should be crushed to increase dispersing actions (prevent retention of unwanted pathogenic Qi)

Combo with heat-clearing herbs in hepatitis

21
Q

Serenoa repens

Godfrey

A

(saw palmetto)
MALE REPRO TONIC + DIURETIC + ENDOCRINE AGENT

Conditions: benign prostate enlargement, epididymitis, nasal bronchial catarrh, pertussis, laryngitis. All GU infx.

Dr Gilbert says: anti bacterial/fungal/viral + inhibits DHT

22
Q

Tabebuia avellanedae

A

(Pau D’arco)
ANIFUNGAL(parasitic) + ANTIMICROBIAL + IMMUNOSTIMULATORY

Conditions: chronic fungal infx, chronic viral infx, inflammatory dx of GI. Gilbert says: cancer

Contains NAPTHOQUINONES therefore NO use with warfarin (blood thinners); NOT to be used in pregnancy.

23
Q

Thuja occidentalis

A

(Thuja)
DIURETIC + GUT ANTISEPTIC + ANTIMICROBIAL
astringent + expectorant

Conditions: psoriasis, warts, thrush, ringworm, catarrh with heart weakness.

THUJA = toxic in large doses; NOT to be used in pregnancy.

24
Q

Usnea spp

A

(Old man’s beard)
ANTIMICROBIAL(bacteria, fungi, virus, parasite) + BITTER

Conditions: viral infx, vaginal douche, fungal infx.

25
Zea mays
(corn silk) URINARY SEDATIVE + DIURETIC + DEMULCENT Conditions: UTI irritation. urethritis, cystitis, prostatitis, lithiasis, gonorrhea.
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Approaching ACUTE infection
Use herbs with more potent immunostimulatory actions Echinacea, Ligustrum, Glycyrrhiza Paired with specific antimicrobials: Hydrastis (& other berberine containing herbs), Ligusticum porterii, Alium, Usnea Generally, tonifying herbs are contraindicated in acute infections -> Add too much energy to an excess condition, feed the infection E.g. Astragalus, Codonopsis, Panax spp.
27
Approach to CHRONIC infection
Long-term infection may indicate an unresolved acute process, weak immunity, infection prone or weakness in organs/tissues, genetic susceptibility, nutritional issues E.g. Chronic bronchitis, recurrent UTI’s, chronic prostatitis, herpes, diabetes Treatment strategies: Correct underlying cause (e.g. Vaginal dysbiosis predisposing chronic yeast infections) Eliminate underlying infection-> antimicrobials, immunostimulants Activate and build long-term immune function, resistance E.g. Ganoderma, Withania, Astragalus Rehabilitate affected organs and systems with specific herbal medicines
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Post Infection Recovery/Chronic Debility
Long term physical, emotional, physiological stress Lowered vitality, increased toxicity, metabolic dysfunction Susceptible to severe depletion after infection or corticosteroid use Chronic Fatigue Syndrome, fibromyalgia Require long term immune system support, adrenal tonics, adaptogens Treatment centres on use of the deep immune activators Astragalus, Schisandra, Ganoderma, Glycyrrhiza, Borago, Eleutherococcus, Panax spp.
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Major Indications for Immune Herbs
Prevention of infection / prophylaxis for cold/flu Immune system adaptogens Astragalus, Echinacea, Codonopsis, Eleutherococcus, Ganoderma Auto-Immune Conditions Increase innate immunity, decrease acquired immunity (Immunomodulation) Uncover and treat activation factors (infection, GI permeability and dysbiosis) Allergies Decrease hypersensitivity, treat underlying aggravation Cancer Prevention: increase immune surveillance Treatment: Increase NK cells, cytokines like TNF Treat side effects from conventional treatments
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Major Constituents to Keep in Miind
Caffeic acid Common phenylpropanoid: phenolic compound characterized by an aromatic ring to which a 3-carbon side chain is attached Analgesic, anti-inflammatory, antibacterial, antifungal, antiviral and antioxidant properties E.g. echinacoside (Echinacea) Polysaccharides High molecular-weight polymers made up of monosaccharide units Effects on immune system: activate T-lymphocytes, increase certain serum proteins, activate complement system, stimulate interferon production, increase phagocytosis E.g. β-glucans (Ganoderma) Saponins 3 common properties: bitter taste, hemolytic activity, and form stable foams when shaken in water General pharmacological actions include: adaptogenic, alterative/tonic, anthelminthic, antifungal, anti-inflammatory, antimicrobial, anti-ulcerogenic, capillary strengthening, cholesterol lowering, diuretic, expectorant, hemolytic, hepatoprotective, hormone modulating, immunomodulating, molluscicidal, piscicidal, spermicidal and contraceptive Enhance humoral and cellular immune responses Some induce ACTH and corticosterone release E.g. astragaloside (Astragalus), Codonopsis, ginsenosides (Panax spp.), eleutherosides (Eleutherococcus), glycyrrhizin (Glycyrrhiza) Pyrrolyzidine alkaloids E.g. Borago
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Common Interactions to be Aware of!
May interfere with immunosuppressive drugs (Astragalus, Eleutherococcus, Ganoderma, Withania) Additive hypoglycemic effects w/ insulin (Eleutherococcus, Panax ginseng, P. quinquefolius) Improves outcome w/ interferon (Astragalus) Enhances outcome w/ chemotherapy (Panax ginseng, P. quinquefolius) Decreases gastric ulceration due to aspirin (Glycyrrhiza) Inhibits liver toxicity of acetaminophen (Glycyrrhiza, Schisandra) May lead to hypertension and hypokalemia (Glycyrrhiza) DGL (deglycyrrhizinated licorice), frequently used to treat ulcers, does not; however, it also loses its adrenocorticotrophic activity May lead to hypertension, esp. when used w/ caffeine (Panax ginseng) Avoid concommitant use of stimulants
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Toxicity of Immune Herbs
Borago: Leaves and flowers contain hepatotoxic pyrrolizidine alkaloids – caution w/ long term use Seed oil does not contain toxic constituents Glycyrrhiza: Glycyrrhizin may lead to pseudoaldosteronism – hypokalemia, hypernatremia, edema, hypertension, weight gain, vertigo, headaches Assess BP prior to administration and monitor regularly Panax ginseng: High doses may lead to Ginseng Abuse Syndrome (GAS): hypertension, euphoria, nervousness, insomnia, skin eruptions, & morning diarrhea (traditional antidote is mung bean soup)
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How Do Antimicrobials Work?
Directinteractionw/pathogen E.g. Melaleuca’s volatile oil content kills pathogens by interfering w/ their metabolism Indirect action by stimulating immune response E.g. Echinacea spp. stimulates NK & T-cell mediated immunity Secondary actions that affectmicrobial abilities Arctostaphylos has anti-adherent properties, blocking E. coli from attaching to urinary tract mucosa
34
How Should we Choose Antimicrobial Herbs?
Choose antimicrobials which have: Affinity for body system(s) involved Affinity for type of pathogen Strength commensurate with vitality of patient Different constituents than other botanicals in the formula Specificity for pathogen involved +relevant tonics + system support Once acute infection is over: Tonify body system(s) involved Usebitters, immunomodulators, adaptogens, hepaticalteratives and diuretics as indicated to restore overall health an