immune cell markers Flashcards
(19 cards)
CD45
transmembrane protein tyrosine phosphatase expressed on all hematopoeitic cells
hematopoietic
in reference to the hematopoietic stem cells which originate in the bone marrow and result in the immune cells
F4/80
glycoprotein found on mouse macrophage and low expression on monocytes
cd64
Fc receptor that binds monomeric IgG-type antibodies with high affinity.
ly6G
Ly6G, or lymphocyte antigen 6 complex locus G6D… neutrophils,
cd11b
CD11b regulates leukocyte adhesion and migration to mediate the inflammatory response… found on interstitial mac, transitional macs, monocytes and neutrophils
cd11c
CD11c is a widely established marker for dendritic cells… but also weirdly alveolar macs
Siglec F
marker of alveolar Macs and eosinophils
cx3cr1
inflammatory chemokine receptor important for transitional macrophage and interstitial macs
MHCII
major histocompatibility complex 2- a transmembrane protein that presents antigens to CD4+ T-lymphocytes…
CD24
found on dendritic cells and neutrophils … helps to c0stimulate T cell proliferation
CD103
found on cDC1 and is an Integrin CD103 mediates the adhesion and tissue retention of T cells by binding to E-cadherin which is abundant on epithelial cells
Cd8a
activation marker on dendritic cells class 1
P-DCA-1
pDCs are known for their ability to secrete high levels of type I interferon (IFN-α/β) in response to viral infections and nucleic acids derived from viruses. They also have the ability to present antigens pDCs accumulate in the nasal mucosa in experimentally induced nasal allergy RARE
CD115
a glycoprotein that’s a cell-surface receptor that’s important for the survival and differentiation of monocytes and macrophages (macrophage colony-stimulating factor receptor,—— important for classical monocytes
Ly6c
marker to differentiate non classical and classical monocytes - its classical!!!
CD24
highly expressed on neutrophils
Cd80
co-stimulatory marker for t cells
Cd86
co-stimulatory marker for t cells
