Immune Drugs Flashcards
(27 cards)
Cyclosporine
Calcineurin inhibitor; binds cyclophilin. Blocks T-cell activation by preventing IL-2 transcription.
Tacrolimus
Calcineurin inhibitor; binds FK506 binding protein (FKBP).
Blocks T-cell activation by preventing IL-2 transcription.
Sirolimus
mTOR inhibitor;
binds FKBP.
Blocks T-cell activation and B-cell differentiation by preventing response to IL-2.
monoclonal antibodies that block IL-2R
Daclizumab
Basiliximab
Mycophenolate`
Reversibly inhibits IMP dehydrogenase, preventing purine synthesis of B and T cells.
corticosteroids
inhibit NF-κB. Suppress both B- and
T-cell function
target for ALEMTUZUMAB
CD 52
almetuzumab treats what two things
CLL and MS
Bevacizumab treats what two things
colorectal cancer and renal cell carcinoma
Cetuximab treats
Stage 4 colorectal cancer
head and neck cancer
Rituximab treats
CLL
non hodgkin lymphoma
RA
ITP
Ifliximab treats
IBD
RA
Ankylosing Spondylitis
Psoriasis
Eculizumab treats
Paroxysmal Nocturnal Hemoglobinuria
target if the RANKL receptor
Denosumab
inhibits osteoclast maturation and treats osteoporosis
Denosumab
Targets the IgE and treats allergic asthma and prevents IgE from binding to the FC region
Omalizumab
treatment for neovascular age related macular degeneration
Bevacizumab and Ranibizumab
RSV prophylaxis for high risk infants
Palivizumab
aldesleukin
IL-2
renal cell carcinoma and malignant melanoma
Epoetin Alfa
EPO
anemia
Filgrastim
G-CSF
recovery of bone marrow
Sargramostim
GM-CSF
recovery of bone marrow
IFN-alpha
chronic hep B and C
malignant melanoma
Kapsoi sarcoma
IFN -B
MS
