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POM Y1 Imperial > Immune response > Flashcards

Immune response Flashcards

1
Q

What is the innate immune system?

A

Refers to non-specific defense mechanisms that activate within initial exposure to an antigen; includes germline-encoded receptors - unchangeable genome binds to particular ligands

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2
Q

What are the physical barriers of immunity?

A

Skin, mucous, epithelial cells

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3
Q

Which immunological factors form the humoral system?

A

Complement, lectins (collectins, ficolins), lectins prevent polysaccharide capsule bacteria from bindin, pentraxins, antimicrobial peptides

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4
Q

What is the adaptive immune system?

A

Highly specialized defense mechanism against specific pathogen-variable receptors that undergo maturation (DNA recombination), memory response

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5
Q

Which microbial factors are used in the adaptive humoral response?

A

Antibodies, complement

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6
Q

What immunological cells form the adaptive immune system?

A

Cytotoxic T cells, t helper cells, t regulatory cells, b lymphocytes, and plasma cells

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7
Q

What are the four main pathological niches?

A

Extracellular
Intracellular
surface adherent
Intracellular cytosolic

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8
Q

What are extracellular niches?

A

Staphylococcus, streptococcus, candida, microbiota (worms), Pathogens secrete toxins and are suspended in tissue

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9
Q

What are intracellular niches?

A

Salmonella requires host cell organelles to translate and synthesize proteins (viruses)

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10
Q

What are surface adherent niches?

A

Enteropathogenic and enterohaemorrhagic E.coli Require close proximity to host cells. Adhesive tips enable bacteria to attach to specific host cells receptors. Cell wall adhesins are surfaced proteins in the cell wall of bacteria that bind tightly to specific receptor molecules on host cell surface membranes

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11
Q

What are intracellular cytosolic niches?

A

Phagocytosed pathogen integrates and suspends in the cytosol of cell (Listeria)

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12
Q

What is the circulating life span of neutrophils?

A

6 hours, short lived, followed by macrophages

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13
Q

How are Naive neutrophils activated?

A

Activated upon interaction with the pathogen and are attracted towards the area of infection by chemotaxis

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14
Q

Which class of chemotactic protein is released for neutrophil chemotaxis?

A

Leukotrienes

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15
Q

Where do neutrophils arise from?

A

Bone marrow through differentiation of HSCs into lymphoid precursors, neutrophils are unable to replicate.

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16
Q

What is the purpose of phagocytes?

A

Control infection (undergoing phagocytosis to hydrolyse pathogens, reducing pathogenic load), and limit/repair tissue damage

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17
Q

What does unregulated phagocytic activity result in ?

A

Granuloma (Collection of neutrophils/macrophages that exclude of an area) formation; excessive inflammation and inappropriate adaptive immunity, and tissue damage

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18
Q

What are interleukins?

A

Are communicatory glycoproteins released by leukocytes that regulate immune response-cytokines

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19
Q

Which receptors does IL bind onto?

A

IL receptors, consequently contributing to gene expression of naive cells activates macrophages

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20
Q

What are the three stages that occur for the sequence of molecular and cellular events in terms of activation of host immunological cells?

A

1) Microbial ligand detection
2) Naive host cells undergo gene-expression changes
3) Cytokine and chemokine release causes signal transduction

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21
Q

Where do macrophages reside?

A

Tissue-resident or circulatory

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22
Q

Which cytokines induce macrophage activation?

A

IL-12/18/1, TNF & IL-6

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23
Q

What functions are displayed by activated macrophages?

A

Phagocytosis and migration; cytokine/chemokine production, expression of cell surface molecules; antimicrobial activity; antigen presentation and T cell activation

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24
Q

What inflammatory properties are expressed by activated macrophages?

A

They are anti-inflammatory

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25
Which interferon is the primary activator of macrophages?
IFN-y
26
Which interferon induces Class II MHCs on macrophages?
IFN-y
27
Which cells secrete cytokines which stimulate macrophage phagocytosis of pathogens?
T-lymphocytes
28
How is the specificity of immunological response dictated by cytokines?
The specificity of the response is attributed to the definite secretion of cytokines that confers to particular gene expressions to respond to the pathogen
29
What are interferons?
Interferon molecules are cytokines that express direct antiviral activities
30
What do antiviral genes encode for?
Nucleases (cleaves terminals fo viral nucleic acid) Inhibitors of viral entry and exit Inhibition of viral uncoating and replication Inhibitors of protein translation
31
What are the three main immunomodulatory roles?
The enhanced T-cell response, anti-inflammatory actions, and tissue repair
32
How are infected cells killed by the immune system?
Killed by the action of cytotoxic T lymphocytes (CTLs)/ natural killer (NK) cells.
33
How are NK cells activated?
Independent of MHC recognition; are activated in response to secreted interferons or macrophage-derived cytokines. NK cells work to control viral infections by secreting IFN-y & TNF-a
34
How do NK and CTL cells control viral replication?
Cell death stimulated by these cells, removes viral replication niches, reducing the rate of viral load increments Directly kill infected cells through contact-dependent mechanisms
35
How do intracellular bacterial infected cells undergo contract independent cell death?
Through cytokine stimulation
36
What are the four soluble effect mechanisms of the humoral innate immune system?
Complement mediated Lectin binding Iron chelation Antibiotic-like peptides
37
What is the function of lectins?
Lectin-binding is responsible for the neutralization of cell attachment/entry
38
What is the function of iron chelation by siderophores?
Prevents replications
39
What are the 2 cell effector mechanisms for the humoral innate system?
Reactive oxygen and nitrogen radicals, acidification and digestion within phagosomes Lysosomes secreted hydrolytic lysosomal enzymes that cleave pathogenic peptides within the phagocytic vacuole - components are expressed onto MHC molecules of cell surface membrane for adaptive immune response as an antigen-presenting cells
40
Which MHC class is recognized by CD4 cells?
MHC-II
41
Which MHC class is recognized by CD8 cells?
MHC-I
42
Which immune cells are antigen-presenting cells?
Activated macrophages and dendritic cells
43
Which interleukin secreted by antigen-presenting cells promotes T-cell replication?
IL-12
44
Which cytokine upregulates MHC-II expression for antigen presentation?
IFN-y
45
Which class of cells activate T-helper cells?
Dendritic cells and macrophages, the presented MHC-antigen complex associated with the cell membrane binds to complementary TCRs of the naive T-cells. Binding mechanism results in the secretion of IL-2 cytokine causes mitotic division and specialization into active T-helper cells and T-memory cells
46
Which interleukin is secreted from activated naive T-cells which stimulates subsequent mitotic division?
IL-2
47
What do B-cell receptors detect?
Detect antigenic epitopes
48
What happens to the bound antigen onto the BCR?
Through receptor-mediated endocytosis by the B cell, the antigen undergoes antigen processing, the processed peptide fragments are expressed by MHC molecules on the cell surface membrane, and are subsequently recognized by T helper cells with complementary CD4 t cell receptors
49
What is the purpose of opsonization?
Mark infected cells, and pathogens, thus facilitating phagocytosis
50
What is the purpose of Th1 cells?
The lineage of CD4+ affect T cells, that promotes cell-mediated immune responses, required for host defense against intracellular viral and bacterial pathogens Th1 cells secrete IFN-y, IL2/10, TNF-alpha/beta Macrophage activation
51
What is the purpose of Th2 cells?
Mediate the activation & maintenance of the humoral and antibody-mediated immune response against extracellular bacteria, allergens, and toxins
52
What are the two classes of innate immune T cells?
T delta & gamma, these are early responders and are MHC independent
53
What is the principal target for Th1 cells?
Macrophages,
54
What role do Th1 exhibit in disease?
Autoimmunity and chronic inflammation
55
Which are the defining cytokines released from Th1 cells?
IL4/5/13
56
What is the principal target cell for Th2 cells?
Eosinophils
57
What are the main immune reactions stimulated by TH2 cells?
Eosinophil and mast cell activation Alternative macrophage activation Defense against helminths
58
Which t cells are mainly evident in allergy?
Th2
59
What are the defining cytokines released from Th17 cells?
Il17/22
60
What are the primary target cells for Th17 cells?
Neutrophils
61
What are the major immune reactions stimulated by Th17 cells?
Neutrophil recruitment and activation
62
Which Th cell subset is responsible for defense against extracellular bacteria and fungi?
Th17
63
What is Chediak-Higashi syndrome?
Compromised lysosomes

POM Y1 Imperial (34 decks)

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