Immune response to infection

Question 1

What are some examples of extracellular bacteria

Answer 1

Staphylococcus, Streptococcus, Candida

Question 2

What are some examples of intracellular vacuolar

Answer 2

Salmonella, Chlamydia, Legionella

Question 3

What are some examples of surface adherent

Answer 3

Enteropathogenic and enterohaemorrhagic

Question 4

what are some examples of intracellular cytosolic

Answer 4

Virus, Listeria, Burkholderia

Question 5

How does an immune response to the infection start

Answer 5

Tissue damage
Molecular detection of microbes
Inter-cellular communication
Priming of the adaptive immune response

Question 6

How does an immune response to infection end

Answer 6

Clearing infection
Stopping inflammatory cytokine production
Repairing tissue damage
Remembering the infection

Question 7

Important cytokines secreted by activated macrophages

Answer 7

IL-1 - alarm cytokine, fever
TNF-alpha - Alarm cytokine
IL-6 - Actue phase proteins (liver)
CXCL8/IL-8 - chemotactic for neutrophils

Question 8

IgG facts

Answer 8

Most abundant immunoglobulin
Found as monomer - 4 subclasses
Actively transported across placenta
Major activator of classical complement pathway

Question 9

IgA facts

Answer 9

Protects mucosal surfaces

Dimer

Question 10

IgM facts

Answer 10

Pentameric molecule 5 monomers joined by J chain
First Ig synthesis following exposure to antigen
Activate complement
Efficient at agglutination

Question 11

IgE facts

Answer 11

Binds with high affinity to Fc receptors of mast cells
Difficult to detect in blood
Produce in response to parasitic infections and in allergic disease
Cross linking triggers mast cell activation and histamine release