Immunisation and Prophylaxis Flashcards

1
Q

When is immunisation currently recommended?

A

Childhood schedule
Special patient groups
Occupational
Travellers

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2
Q

When is prophylaxis recommended?

A

Travellers
Post-exposure
Post-exposure HIV
Surgical

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3
Q

How does active immunisation work?

A

Antigen stimulates the immune espouse which provides long-term immunity
Relies on immunological memory

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4
Q

Does active immunisation produce an immediate effect?

A

No immediate effect - but faster and better response to next antigenic encounter

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5
Q

Vaccine types

A

Live attenuated
Killed/inactivated
Detoxified exotoxin
Subunit

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6
Q

Examples of live attenuated vaccines

A
Measles 
Mumps 
Rubella 
Polio
BCG 
Varicella Zoster virus 
Yellow fever 
Typhoid
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7
Q

How do live attenuated vaccines work?

A

Attenuation of pathogenic organism by repeated passage in cell culture or non-human host
Usually promotes a full long-lasting antibody response after one or two doses

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8
Q

Contraindications for live attenuated vaccines

A

Pregnancy

Immunocompromised

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9
Q

Why might the storage of live attenuated vaccines be difficult in developing countries?

A

They require refrigeration until administration

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10
Q

Examples of inactivated/killed whole cell vaccines

A
Pertussis 
Polio 
Influenza 
Hepatitis A 
Cholera 
Rabies 
Japanese encephalitis 
Tick borne encephalitis 
Smallpox
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11
Q

How do inactivated/killed whole cell vaccines work?

A

Pathogenic organism inactivated by chemical inactivation, usually with formaldehyde
Promote weaker immune responses in comparison to live vaccines

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12
Q

Possible side effects of inactivated vaccines

A

Inflammatory responses against other proteins and antigens contained within the vaccine

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13
Q

Examples of detoxified exotoxin vaccines

A

Tetanus

Diphtheria

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14
Q

How do detoxified exotoxin vaccines work?

A

Toxin treated with formalin
Toxoid retains the antigenicity but has no toxic activity
Only induces immunity against the toxin, not the organism that produces it

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15
Q

Examples of subunit vaccines

A
Pertussis - acellular 
Haemophilus influenzae type B 
Meningococcus groups A, C, W and Y 
Pneumococcus 
Hepatitis B 
Typhoid 
Anthrax
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16
Q

Benefits of subunit vaccines

A

Safe to use as there is no infectious agent and they are highly purified
Easy to produce large amounts

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17
Q

Disadvantage of subunit vaccines

A

Increased purity leads to loss of immunogenicity - may need an adjuvant

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18
Q

Example of recombinant vaccine

A

Hepatitis B surface antigen for HBV vaccination

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19
Q

How are recombinant vaccines prepared?

A

Gene encoding the antigen is excised from the organism’s nucleic acid, purified and mixed with plasmids
Gene is then inserted into yeast chromosome which grows in culture to produce the antigen

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20
Q

Immunisation schedule for 2 months old

A
Diphtheria 
Tetanus 
Bordetella pertussis
Polio 
Haemophilus influenzae B
Pneumococcal conjugate
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21
Q

Immunisation schedule for 3 months old

A
Diphtheria 
Tetanus 
Bordetella pertussis 
Haemophilus influenzae B 
Men C
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22
Q

Immunisation schedule for 4 months old

A
Diphtheria 
Tetanus 
Bordetella pertussis 
Haemophilus influenzae B
Men C 
Pneumococcal conjugate
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23
Q

Immunisation schedule for 1 year old

A
Haemophilus influenzae B 
Men C 
MMR 
Pneumococcal conjugate 
Men B
24
Q

Immunisation shcedule for 2, 3 and 4 years old

25
Immunisation schedule for 3-5 years old
4-in-1 booster DTaP, IPV | MMR
26
Immunisation schedule for 12-13 year old girls
Human papilloma virus
27
Immunisation schedule for 14 years old
3-in-1 booster DT, IPV and men ACWY
28
What is herd immunity?
Vaccinated individuals less likely to be a source of infection to others This reduces the risk of un-vaccinated individuals being exposed to infection Individuals who cannot be vaccinated therefore still benefit from routine vaccination
29
At what age are infants vaccinated with the new rotavirus vaccine and what protection does it offer?
Babies at 2 and 3 months | 90% protection
30
Immunisation recommended for special patient and occupational groups
``` BCG Influenza Pneumococcal Hepatitis B Varicella-zoster ```
31
Who is the BCG vaccination still given to?
``` Some infants (0-12 months) from areas of the UK with an annual incidence of 40 or more per 100,000 or with parents/grandparents born in a country with an annual incidence of TB of 40 or more per 100,000 ``` Children screened at school for TB risk factors if appropriate New immigrants, previously unvaccinated, from high prevalence countries Contacts of respiratory TB patients Healthcare workers
32
Example of the patient groups recommended to get the influenza vaccination
``` Nursing home residents Healthcare workers Immunodeficiency Immunosuppression Asplenia/hyposplenism Chronic liver, renal, cardiac or lung disease Diabetes mellitus Pregnant women Coeliac disease Age > 65 ```
33
In what adult groups is pneumococcal polysaccharide vaccine recommended?
``` Immunosuppression Immunodeficiency Asplenism/hyposplenism Sickle cell disease Chronic liver, renal, cardiac or lung disease Diabetes mellitus Coeliac disease ```
34
In what patient groups is hepatitis B vaccination given?
``` Children at high risk of exposure to HBV Babies born to infected mothers Healthcare workers IVDA Men who have sex with men Prisoners Chronic liver or kidney disease ```
35
In what patient groups is varicella vaccination (chickenpox) given?
Patients who have a suppressed immune system Children in contact with those at risk of severe VZV Healthcare workers if sero-negative and in contact with patients
36
Dosage of varicella vaccine
Aged 1-12 years - 1 dose | Aged 13 or older - 2 doses, 4-8 weeks apart
37
In what patient group is the herpes zoster vaccination given?
All elderly patients, 70+
38
Use of human normal immunoglobulin
Contains antibodies against hepatitis A, rubella, measles Used in immunoglobulin deficiencies Treatment of some autoimmune disorders
39
Examples of disease-specific immunoglobulin
``` Hepatitis B Ig Rabies Ig Tetanus anti-toxin Ig Varicella Ig Diphtheria anti-toxin Botulinum anti-toxin ```
40
Examples of agents used in passive immunisation
Human normal immunoglobulin Human specific immunoglobulin Diphtheria anti-toxin Tetanus anti-toxin
41
Examples of natural passive immunisation
``` Placental transfer of IgG Colostral transfer of IgA Human normal immunoglobulin Human specific immunoglobulin Disease-specific immunoglobulin ```
42
Examples of artificial passive immunisation
Treatment with immunoglobulin | Immune cells
43
Advantages of passive immunisation
Gives immediate protection
44
Disadvantages of passive immunisation
Short-term effect Serum sickness Graft vs host disease
45
Possible contraindications of vaccination
Febrile illness Pregnancy Allergy Immunocompromised
46
Risk assessment of the traveller
``` Health of traveller Previous immunisation and prophylaxis Area to be visited Duration of visit Accommodation Activities Remote areas Recent outbreaks ```
47
General measures to be advised when travelling
``` Care with food/water Hand washing Sunburn/sunstroke Altitude RTAs Safe sex Mosquitoes ```
48
Common immunisation for travellers
``` Tetanus Polio Typhoid Hepatitis A Yellow fever Cholera ```
49
Immunisations for travellers in specialised circumstances
``` Meningococcus ACWY Rabies Diphtheria Japanese B encephalitis Tick borne encephalitis ```
50
Prophylaxis options
Chemoprophylaxis against malaria Post-exposure prophylaxis HIV post-exposure prophylaxis Surgical antibiotic prophylaxis
51
ABCD of malaria prevention
A - awareness of risk B - bite prevention C - chemoprophylaxis D - diagnosis and treatment
52
Bite prevention advice
Cover up at dawn and dusk Insect repellent sprays/lotions Mosquito coils Permethrin-impregnated mosquito nets
53
Chemoprophylaxis for malaria
Malarone daily Mefloquine weekly Doxycycline daily Chloroquine weekly and proquanil daily for vivax, ovale and malariae
54
Contraindications for mefloquine use
History of psychosis or epilepsy | Side effects of psychosis and nightmares
55
Malaria advice to travellers on return
Any illness occurring within 1 year, and especially within 3 months, of return might be malaria Patients should seek medical attention if they become ill, particularly within the 3 months