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IMMUNOSEROLOGY > Immunity > Flashcards

Immunity Flashcards

(76 cards)

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1
Q

Other term of Natural Immunity?

A

Innate/Non specific

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2
Q

Inborn - provide wide range defense

A

Natural Immunity

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3
Q

Can migrate 30-60 mins to the site of infection

A

Phagocytes/Neutrophils

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4
Q

Type of immunity that continues to develop?

A

Adaptive Immunity

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5
Q

Other term of Adaptive Immunity

A

Acquired/Specific

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6
Q

Consists of the anatomical barriers that prevent infectious agents from infecting the body?

A

First line of defense

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7
Q

Ex of First line of defense

A

Intact Skin, Mucous Membranes, Cilia in Respiratory Tract and Body Secretions

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8
Q

Made from soluble factors or proteins

A

Humoral component

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9
Q

First responders (30-60 mins) and the most efficient phagocyte

A

NEUTROPHILS

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10
Q

If the phagocyte is in the blood?

A

Monocyte

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11
Q

If they migrate to tissue?

A

Macrophages

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12
Q

more efficient in phagocytosis, but compare to neutrophils, it was slower

A

Monocytes/Macrophages

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13
Q

Slow responders - they migrate 16-48 hours in the site of infection

  • Motility is slow
A

Monocytes/Macrophages

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14
Q

Less efficient phagocyte

A

Eosinophils

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15
Q

Major basic protein

A

Eosinophils

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16
Q

Granules contain anti-helminthic properties and nematodes (ex. Ascaris, trichuris, strongyloides)

A

Eosinophil Cationic Protein

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17
Q

If there’s a parasitic infection like trichuris, patient may have?

A

EOSINOPHILIA

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18
Q

Has a role in killing parasites/helminthes

A

Eosinophil

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19
Q

Able to present antigen to Helper t cells

A

Antigen Presenting cells (APC)

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20
Q

It’s main function is to eat pathogens then present it for recognition

A

Dendritic cells

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21
Q

Most efficient APC?

A

Dendritic cells

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22
Q

Main function is phagocityze antigen and present to helper t lymphocytes

A

APC (Antigen Presenting Cells)

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23
Q

Primarily cytotoxic - they destroy cells directly and secrete cytotoxic substances

A

Natural Killer Cells

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24
Q

Kills virus infected cells and tumor cells?

A

Natural killer cells

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25
Highest line of defense?
3rd line of defense
26
Cellular component of specialized lymphocytes?
B cells and T cells
27
Has it's roots in the study of Immunity - the condition of being resistant to infection
IMMUNITY
28
Performed the first vaccination against smallpox using cowpox?
Edward Jenner
29
Considered the father of immunology for his attenuated vaccines
Louis Pasteur
30
He was the first to observe the phagocytosis - meaning cells that eat cells
Metchnikoff
31
Cells that eat cells?
Phagocytosis
32
Humoral component of Third Line of Defense?
Antibodies - IgG, IgA, IgM, IgD, IgE Cytokines
33
What are the stages of Phagocytosis?
Adherence Formation of Phagosome Engulfment Formation of Phagolysosome Granule Contact Digestion Excretion
34
Nomenclature of the Liver?
Kupffer Cells
35
Nomenclature of the Lungs?
Alveolar Macrophage/Dust cells
36
Nomenclature of the Brain/Nervous Tissue?
Microglial cells
37
Nomenclature of the connective tissue?
Histiocytes
38
Nomenclature of the Spleen?
Splenic Macrophage
39
Nomenclature of the Lymph nodes?
Littoral cell
40
Nomenclature of the Placenta?
Hofbauer cells
41
Bones?
Osteoclasts
42
Kidney?
Mesangial cells
43
Surface receptors that promote cell to cell interaction?
Integrins
44
Substances that coat foreign cells and pathogen to make then more susceptible to phagocytosis?
Opsonin
45
Ex of Opsonins
CRP, Antibodies, C3b
46
Normal serum constituents that increase by at least 25% due to infections, injury, or trauma to tissues?
Acute phase reactants
47
Ex of Acute phase reactants?
CRP, Serum Amyloid A, Alpha-1 antitrypsin Fibrinogen Ceruloplasmin Haptoglobin C3
48
We produced antibodies after infection or we are infected by certain pathogens, pag nakarecover na tayo we will produce our own antibodies around 3- 5 days.
INFECTION
49
Induced production of antibodies (but in acc to studies, the production of antibodies will decline after 6 months kaya need ng booster
Vaccination
50
Mother will transfer her gG to her baby during pregnancy this was important because the newborn are not able to produce their own antibodies so they will rely to the lag that come from the mother, especially in the 1# few days of the life of the baby
Placental transfer of IgG
51
Also knows as: Null cells Large Granular Lymphocyte Third Population Lymphocyte
Natural Killer cells
52
Why does B cell involved in humoral immunity?
Because its major product is antibodies
53
E-rosette receptor?
CD2
54
Part of T-cell antigen receptor?
CD3
55
Helper T cell/Treg cell?
CD4
56
Early stages of T cell?
CD5/CD7
57
Part of B cell coreceptor?
CD19
58
Found on all stages of B cells
CD20
59
Receptor for C3d and EBV
CD21
60
Found mostly oncmature B cells
CD27
61
receptor for IgG
CD16
62
No known function
CD56
63
Cortex of thymus?
Immature T cells
64
Medulla of Thymus?
Mature T cells
65
It is bilobed organ located in the mediastinum or chest cavity?
THYMUS
66
site for both B cell development and hematopoiesis?
Bone marrow
67
develop in the bone marrow after the hematopoietic stem cells have populated that organ?
B cells
68
contains macrophages that destroys old RBCs
RED PULP
69
Has lymphocytes and and macrophages
White pulp
70
Periaarteriolar Lymphoid Sheath?
T cells
71
Primary follicles
B cells
72
Marginal zones
Dendritic cells
73
Out cortex of Lymph nodes?
B cells, dendritic, and macrophage
74
Germinal center of Lymph nodes
Plasma cells and memory cells
75
Migration time of Monocytes/Macrophage?
16-48 hours
76
Increases by 1000, rises within 6-10 hours
Acute phase reactant

IMMUNOSEROLOGY (1 decks)

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