Immunity Flashcards
What are 8 aspects of adaptive immunity
Immunity established to adapt to infection
Specific or acquired immunity
Learns by experience - has memory
Enhanced by second exposed
Confers pathogen specific immunity
Uses cellular and hu oral components
Poorly effective without innate immunity
Antibodies reflect infections - varicella after chickenpox
Four main overview points about innate immunity
Trigepgered by receptors that bind sequences of sugars, lipids, amino or nucleic acids common in bacteria and microorganisms
Receptors activate various defence mechanisms
Receptors and encoded in germ line and their fundament structre isn’t modified by exposure of antigen
Defences include cytokines, ohagoctosis, production of antibacterial peptides and complement system
What 5 cells are involved in innate immunity
Macrophage Neutrophil Eosinophil Basophils Mast cell
What are the 5 innate immunity receptors
Complement receptors Mannose receptors CD14 Glycan receptors Toll-like receptors (TLR1-9)'
What is opsonisation
The coating of a microorganism by antibodies or complement to render it recognisable as foreign by phagocytes - enhancing phagocytosis
What are 6 main overview points about adaptive immunity
- T and B lymphocytes activated by specific antigens
- T cells have receptors related to antibody molecules - cell bound
- When receptors encounter cognate antigen - T cells proliferate, produced cytokines that activate immune response and B cells
- activate B cells from clones that produce secreted antibodies which attack foreign bodies
- after invasion some T and B lymphocytes persist and memory
- memory cells provoke a rapid magnified response against second exposure
What are the 8 aspects of innate immunity
Inbuilt immunity to resist infextion Present from birth Not specific Not enhanced by exposure No memory Uses cellular and humongous components Poorly effecting without adaptive memory Involved in triggering and amplification of adaptive immune response
