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organ systems > immuno > Flashcards

immuno Flashcards

1
Q

HLA-A2

A

hemochomatosis

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2
Q

HLA-B27

A

psoriatic arthritis
ankylosing spondyloarthritis
IBD-associated arthritis
reactive arthritis

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3
Q

HLA-DQ2/DQ8

A

celiac disease

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4
Q

HLA-DR2

A

multiple sclerosis
hay fever
SLE
goodpasture syndrome

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5
Q

HLA-DR3

A

DM 1
SLE
graves
hashimoto

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6
Q

HLA-DR4

A

rheumatoid arthritis

DM 1

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7
Q

HLA-DR5

A

pernicious anemia

hashimoto

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8
Q

IgG

A

secondary (delayed) response to Ag
most abundant isotype in serum
fixes complement
crosses placenta - passive immunity to infant
opsonizes bacteria
neutralizes bacterial toxins & viruses

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9
Q

IgA

A

in mucosa
prevents attachment of bacteria & viruses to mucous membranes
monomer in circulation, dimer when secreted
crosses EP cells via transcytosis
prod in Peyers patches –> protect GI from infxn
most produced Ab overall, but lower serum concentrations
released in secretions (tears, saliva, mucus) & breast milk

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10
Q

IgM

A

primary (immediate) response to Ag
fixes complement
Ag Rc on B cells
monomer on B cell, pentamer when secreted = avid binding to Ag

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11
Q

IgD

A

unclear fxn

on surface of B cells & in serum

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12
Q

IgE

A

binds mast cells & basophils
crosslinks when exposed to allergen –> release of inflammatory mediators –> type I hypersensitivity rxn
activates eosinophils in parasitic infxns
lowest concentration in serum

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13
Q

C-reactive protein

A

acute phase reactant
opsonin
fixes complement & facilitates complement

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14
Q

ferritin

A

binds & sequesters iron to (-) microbial iron sequestration

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15
Q

fibrinogen

A

coagulation factor
promotes endothelial repair
correlates w/ ESR

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16
Q

hepcidin

A

prevents release of iron bound by ferritin –> anemia of chronic disease

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17
Q

IL-1

A

fever, acute inflammation
activates endothelium to express adhesion molec
induces chemokine secretion to recruit WBC

[macrophages]

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18
Q

IL-2

A

(+) growth of T cells & NK cells

[Th1 &Th2 cells]

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19
Q

IL-3

A

supports growth & differentiation of BM stem cells
fxn like GM-CSF

[TH1 & TH2 cells]

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20
Q

IL-4

A 
induces differentiation into Th2 cells 
promotes growth of B cells 
class switching to IgE & IgG

[Th2 cells]

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21
Q

IL-5

A

promotes differentiation of B cells
class switching to IgA
growth & differentiation of eosinophils

[Th2 cells]

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22
Q

IL-6

A

fever
stimulates production of acute phase reactants

[macrophages]

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23
Q

IL-8

A

major chemotactic factor for neutrophils

[macrophages]

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24
Q

IL-10

A

inhibits Th1
inhibits macrophages

[Th2 cells]

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25
Q

Il-12

A

differentiation into Th1
activates NK cells

[macrophages]

26
Q

TNFa

A 
activates endothelium 
WBC recruitment 
vascular leak 
mediates septic shock 
cachexia in malignancy

[macrophages]

27
Q

IFNy

A

stimulates macrophages to kill phagocytosed pathogens

[Th1 cells]

28
Q

IFNa & IFNb

A

synthesized by virus infected cells –> act locally on uninfected cells to “prime them” for viral defense

  • (-) cellular protein synthesis
  • (+) activation of ribonuclease that degrades viral mRNA

apoptosis –> disrupts viral amplification

29
Q

Th1 cytokines

A

IL-2
IL-3
IFNy

30
Q

Th2 cytokines

A 
IL-2
IL-3
IL-4
IL-5
IL-10
31
Q

macrophage cytokines

A 
IL-1
IL-6
IL-8
IL-12
TNFa
32
Q

helper T cell surface markers

A 
CD4
CD40L
TCR
CD3
CD28
33
Q

cytotoxic T cell surface markers

A

CD8
TCR
CD3
CD28

34
Q

regulatory T cell surface markers

A 
CD4
CD25
TCR 
CD3
CD28
35
Q

B cell surface markers

A 
Ig 
CD19, CD20, CD21
CD40 
MHC I 
MHC II, B7
36
Q

macrophage surface markers

A

CD14
CD40
MHC II, B7
Fc & C3b Rc

37
Q

NK cell surface markers

A

CD16

CD56

38
Q

hematopoietic stem cell surface markers

A

CD34

39
Q

anti-ACh Rc

A

myasthenia gravis

40
Q

anti-basement membrane

A

goodpasture syndrome

41
Q

anticardiolipin

lupus anticoagulant

A

SLE

antiphospholipid syndrome

42
Q

anti-centromere

A

limited scleroderma - CREST syndrome

43
Q

anti-desmosome (anti-desmoglein)

A

pemphigus vulgaris

44
Q

anti-dsDNA

anti-smith

A

SLE

45
Q

anti-glutamic acid decarboxylase

A

DM 1

46
Q

anti-hemidesmosome

A

bullous phemphigoid

47
Q

anti-histone

A

drug induced lupus

48
Q

anti-Jo1
anti-Mi2
anti-SRP

A

polymyositis

dermatomyositis

49
Q

anti-microsomal

anti-thyroglobulin

A

hasimoto thyroiditis

50
Q

ANA

A

SLE

non-specific

51
Q

anti-parietal cell

A

pernicious anemia

52
Q

anti-mitochondrial

A

primary biliary cirrhosis

53
Q

anti-Scl-70

anti-DNA topo I

A

diffuse scleroderma

54
Q

anti-smooth muscle

A

autoimmune hepatitis

55
Q

anti-SSA (anti-Ro)

anti-SSB (anti-La)

A

sjogren syndrome

56
Q

anti-U1 RNP

A

mixed CT disease

57
Q

IgA anti-endomysial

IgA anti-tissue transglutaminase

A

celiac

58
Q

MPO-ANCA / p-ANCA

A

microscopic polyangitis

eosinophilic granulomatosis w/ polyangiitis (Churg-Strauss)

59
Q

PR3-ANCA / c-ANCA

A

granulomatosis w/ polyangiitis

60
Q

rheumatoid factor

anti-citrulinated peptide

A

rheumatoid arthritis

organ systems (3 decks)

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