Immuno Flashcards
(18 cards)
IL-12 activates ____, as well as ____ to produce ____
T helper cell maturity, as well as neutrophils to produce IFN-gamma
TLR-3 recognizes ____
dsRNA
TLR-7 and 8 recognize ____
ssRNA
TLR-9 recognize _____
CpG DNA (CG pairs)
T Cells have what CD receptors?
CD3, CD4, CD8, and CD28
B Cells have what CD receptors?
CD19, CD20, and CD40
Dendritic Cells have what CD receptors?
CD11c and CD123
NK Cells have what CD receptors?
CD56
Stem Cells (HSCs) have what CD receptors?
CD34
Macrophages/Monocytes have what CD receptors?
CD14 and CD33
IL-10 is the only interleukin that is ______
anti-inflammatory
Hierarchy of fever inducing cytokines: ____ > ____ > _____
IL-1 > TNF-alpha > IL-6
IL-6 stimulates _____
acute phase protein production
IL-8 has what function?
Chemotactic: recruits neutrophiles (primarily), and also basophils/ T-cells to site of infection
TNF-alpha is _____ and is responsible for ____
systemic; shock
This cytokine is the only one NOT produced by macrophages, and it’s function is to ______
IFN-gamma; activate macrophages
Classically activated macrophages (M1s) are activated by _____ and/or _____. These cause a _____ response
Activated by TLR binding Ag and/or IFN-gamma.
These cause an inflammatory response
Alternatively activated macrophages (M2s) are activated by ___ and ___. These cause a _____ response by releasing ____ and ____
IL-4 and IL-13
Anti-inflammatory response by releasing IL-10 and TGF-Beta
