Immuno drugs

Question 1

Target/use of alemtuzumab?

Answer 1

CD52, CLL

Question 2

Target/use of bevacizumab?

Answer 2

VEGF, colorectal cancer/renal cell carcinoma

Question 3

Target/use of cetuximab?

Answer 3

EGFR, stage IV colorectal cancer and head/neck cancer

Question 4

Target/use of rituximab?

Answer 4

CD20, B cell non-Hodgkin lymphoma/rheumatoid arthritis/ITP

Question 5

Target/use of trastuzumab?

Answer 5

HER2/neu, breast and gastric cancer

Question 6

Target/use of infliximab, adalimumab?

Answer 6

TNF alpha, PAIR diseases

Question 7

Target/use of natalizumab?

Answer 7

Alpha4-integrin, multiple sclerosis and Crohn disease

Question 8

Target/use of abciximab?

Answer 8

GpIIbIIIa, prevention of ischemic complications in patients undergoing percutaneous coronary intervention

Question 9

Target/use of denosumab?

Answer 9

RANKL, osteoporosis

Question 10

Target/use of digoxin immune fab?

Answer 10

Digoxin, antidote for digoxin toxicity

Question 11

Target/use of omalizumab?

Answer 11

IgE, allergic asthma (prevents IgE binding to the Fc receptor)

Question 12

Target/use of palivizumab?

Answer 12

RSV F protein, RSV prophylaxis for high-risk infants

Question 13

Natalizumab targets alpha4-integrin. What does alpha4-integrin do?

Answer 13

Leukocyte adhesion

Question 14

Natalizumab increases the risk of what disease in a select patient group?

Answer 14

Increased risk of PML in patients with JC virus

Question 15

Epoetin alfa is a recombinant cytokine of what and what is it used for?

Answer 15

Epo - anemias especially in renal failure

Question 16

Oprelvekin is a recombinant cytokine of what and what is it used for?

Answer 16

IL-11, thrombocytopenia

Question 17

Filgrastim is a recombinant cytokine of what and what is it used for?

Answer 17

G-CSF, recovery of bone marrow

Question 18

Sargramostim is a recombinant cytokine of what and what is it used for?

Answer 18

GM-CSF, recovery of bone marrow

Question 19

Aldesleukin is a recombinant cytokine of what and what is it used for?

Answer 19

IL-2, renal cell carcinoma and metastatic melanoma

Question 20

What is thrombopoietin used for?

Answer 20

Thrombocytopenia

Question 21

What is IFN-alpha used for?

Answer 21

Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

Question 22

What is IFN-beta used for?

Answer 22

Multiple sclerosis

Question 23

What is IFN-gamma used for?

Answer 23

Chronic granulomatous disease

Question 24

What two drugs inhibit calcineurin?

Answer 24

Cyclosporin and tacrolimus?

Question 25

What does cyclosporin bind to?

Answer 25

Cyclophilin

Question 26

What does tacrolimus bind to?

Answer 26

FK506 binding protein

Question 27

What does sirolimus (rapamycin) do?

Answer 27

mTOR inhibitor

Question 28

What IL do all the immunosuppressant drugs for prevention of transplant rejection ultimately work on?

Answer 28

Work to prevent IL-2 transcription and signal transduction

Question 29

Target and use of basiliximab?

Answer 29

Blocks IL-2R, kidney transplant rejection prophylaxis

Question 30

What is the mechanism by which glucocorticoids are used in transplant rejection prophylaxis?

Answer 30

Inhibit NF-kB - suppress both B and T cell function by decreased transcription of many cytokines