Immunocap

Question 1

List the main tests carried out on the immunocap

Answer 1

TTG
MPO
PR3
RF
CCP
ENA
CTD screen
Total IgE

Question 2

What is RF and CCP

Answer 2

RF = rheumatoid factor
CCP = cyclic citrulinated peptide IgG

CCP is highly specfiic for rheumatoid arthritis and is more sensitive than RF

Question 3

What is GBM

Answer 3

Glomerular basemement membrane IgG antibodies

Seen in Goodpasture syndrome

Attacks type IV collagen in lungs and kidneys

Question 4

What is goodpasture syndrome

Answer 4

Glomerular nephritis + lung haemorrhage

Question 5

What is PR3

Answer 5

Proteinase 3 IgG

Highly sensitive/specific for Wegener’s Granulomatosis

Cause of C-ANCAs

Question 6

What is MPO

Answer 6

Myeloperoxidase IgG

Autoimmune vasculitides

Cause of P-ANCA staining

Microscopic polyangiitis (MPA)

Question 7

What is the CTD Screen

Answer 7

An Elia screen - one of the pens

Various antibodies

If positive go for ENA testing

Question 8

What are ENAs

Answer 8

Extractible nuclear antigen antibodies

Important in diagnosising connective tissue disorders such as SLE

Question 9

Give some examples of ENAs

Answer 9

dsDNA = double stranded DNA antibodies seen in SLE

SS-A/Ro antibodies seen in Sjogrens syndrome