IMMUNOGLOBULINS

Question 1

This is the most abundant class of antibodies

Answer 1

IgG

Question 2

Where is IgG found?

Answer 2

blood plasma and lymph.

Question 3

How does IgG act on bacteria, fungi, viruses, and foreign particles?

Answer 3

By agglutination, opsonization, activating complement, and by neutralizing toxins.

Question 4

IgG is increased in?

Answer 4

• Liver disease
• Infections
• IgG myeloma
• Parasitic disease
• Many rheumatic disease

Question 5

IgG is deccreased in?

Answer 5

• Acquired immunodeficiency
• Increased susceptibility to infections
• Hereditary deficiency
• Protein-losing states
• Non-IgG myeloma

Question 6

iT is the abnormal increase of plasma cells.

Answer 6

Myeloma

Question 7

“clumping”

Answer 7

Agglutination

Question 8

It coats bacteria for macrophage to easily identify or ingest bacteria.

Answer 8

Opsonization

Question 9

This immunoglobulin is found in small amounts in the blood.

Answer 9

IgA

Question 10

What is the role of IgA?

Answer 10

Defending mucosal surfaces

Question 11

What type of immunoglobulin serves as a first line of defense?

Answer 11

IgA

Question 12

This immunoglobulin is found in the mucosal surfaces.

Answer 12

IgA

Question 13

What are the 2 isotypes of IgA?

Answer 13

o IgA1 (90%)
o IgA2 (10%)

Question 14

IgA are classified according to location, what are these locations?

Answer 14

o Serum IgA
o Secretory IgA

Question 15

IgA are increased in?

Answer 15

• Liver disease
• Infections
• Autoimmune diseases

Question 16

IgA are decreased in?

Answer 16

• Depressed protein synthesis
• Immunodeficiency

Question 17

Where is IgA found?

Answer 17

small amounts in the blood.

Question 18

What cell is IgM present?

Answer 18

B cell

Question 19

This immunoglobulin is present in B cells

Answer 19

IgM

Question 20

This is the only naturally occurring antibody.

Answer 20

IgM

Question 21

This is the first antibody that appears in response to antigenic stimulation.

Answer 21

IgM

Question 22

It is bigger than other immunoglobulins

Answer 22

IgM

Question 23

It is the → ingestion of cat’s stool infected with toxoplasma

Answer 23

Taxoplasmosis

Question 24

IgM is increased in?

Answer 24

• Taxoplasmosis
• Primary biliary cirrhosis
• Cytomegalovirus
• Rubella
• Herpes
• Syphilis
• Various bacterial and fungal diseases

Question 25

IgM is decreased in?

Answer 25

* Protein-losing conditions * Hereditary immunodeficiency

Question 26

It is an antibody that is present on the surface of most but not all B cells early in their development.

Answer 26

IgD

Question 27

Little IgD is released into ____________

Answer 27

circulation.

Question 28

May help regulate B cell function.

Answer 28

IgD

Question 29

The overall function of this antibody is still unknown

Answer 29

IgD

Question 30

IgD is increased in?

Answer 30

* Infections * Liver disease * Connective tissue disorders

Question 31

IgE is produced by?

Answer 31

B cells and plasma cells

Question 32

It is produced by the B cells and plasma cells

Answer 32

IgE

Question 33

What is the concentration level of IgE in the circulation?

Answer 33

Very low

Question 34

It is associated with allergic and anaphylactic reactions.

Answer 34

IgE

Question 35

IgEs associated with __________and ___________ reactions.

Answer 35

allergic anaphylactic

Question 36

TRUE OR FALSE: Non-elevated IgE levels are not diagnostic of any single condition.

Answer 36

False: ELEVATED

Question 37

IgE is Increased in?

Answer 37

* Inflammatory and infectious diseases including asthma and hay fever.