Immunoglobulins and cytokines Flashcards Preview

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Flashcards in Immunoglobulins and cytokines Deck (17):
1

IgG

most common immunoglobulin
enhances phagocytosis
fixes complement and foetal care

2

IgA

found in breast milk
provides localised protection on mucous membranes
it is the most commonly produced Ig

3

IgM

1st Ig made in response to infection
fixes complement
doesn't pass to foetus

4

IgD

not much is known
involved in activating B cells

5

IgE

type 1 hypersensitivity
binds to Fc on mast cells and basophils
provides immunity to parasites

6

what is the role of a cytokine?

have a specific effect in communication and interaction between cells
includes interferon, interleukin and growth factors

7

IL1

macrophages
role in acute inflammation and fever

8

IL2

T helper 1 cell
growth and differentiation of T cell response

9

IL3

activated T cells
T cell proliferation
activates mature neutrophils and macrophages

10

IL4

T helper 2 cells
Differentiation and proliferation of B cells

11

IL5

TH2 cell
stimulates production of eosinophils

12

IL6

macrophages and TH2
differentiation of B cells

13

IL8

macrophages
neutrophil chemotaxis

14

IL10

TH2 cell
anti-inflammatory
inhibits TH1 cytokines

15

IL12

dendritic, macrophage, B-cells
activates NK cells
differentiates T cells into TH1 cells

16

TNF alpha

macrophages
neutrophil chemotaxis

17

interferon gamma

TH1 cells
activates macrophages