Immunology Flashcards
(31 cards)
Where does papain cleave immunoglobulin?
Above the hinge, resulting in 2 Fab fragments and 1 Fc fragment
Where does pepsin cleave immunoglobulin?
Below the hinge, resulting in 1 Fab(2) fragment and 1 Fc fragment
Which cytokine induce production of IgG1?
IFN-g and IL-4
Which cytokine induce production of IgG2?
IFN-g and TGF-b
Which cytokine induce production of IgG3?
IFN-g
Which cytokine induce production of IgG4?
IL-4 and IL-13
Which cytokine induce production of IgA?
TGF-b and IL-5
Which cytokine induce production of IgM?
None. IgM is produced as primary response prior to class switching.
Which cytokine induce production of IgE
IL-4 and IL-13
What does mutation in IL-12Rb1 associated with
Infection with intracellular bacteria, notably salmonella and atypical mycobacteria
What does IRAK-4 deficiency cause?
susceptibility to pyogenic infections, especially strep. pneumonia
What is the cause of Castleman’s disease?
Hyperproduction of IL-6
What receptors got affected in X-linked SCID?
IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21. All contain gc, which is affected in X-linked SCID
What does receptors for IL-3, IL-5 and GM-CSF shares?
Common beta chain
Function of SCF (stem cell factor)
- Act on immature stem cells with c-kit
- Enhances response to other CSFs
- Sustain viability of T cells in the thymus
- Mast cell growth factor
Function of IL-7
Survival of mature, naive, and memory T cell (especially CD4)
Function of IL-3
Promote growth and development of mast cells from bone marrow
- Basophil differentiating cytokine
Function of IL-11
Megakaryocytopoiesis
HIV / AIDS - chemokines / receptor defect
CCR5, CCL3L1, CXCR4, CCR2, CXCL12
WHIM syndrome
CXCR4
HIT (heparin induced thrombocytopenia)
CXCL4
Atherosclerosis
CX3CR1, CCL2
Asthma or allergies
CCL2, CCL5, CCL7, CCL11, CXCL8
Cancer metastases
CXCL12 CXCR4, CXCR7
