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Patho > Immunology > Flashcards

Immunology Flashcards

0
Q

Type of hypersensitivity for transfusion reaction

A

Type II

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1
Q

Histology shows fibrinoid necrosis

A

Vasculitis, Arthrus reaction

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2
Q

Type of hypersensitivity for contact dermatitis

A

Type IV

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3
Q

Type of hypersensitivity for tuberculin reaction

A

Type IV

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8
Q

MC primary deficiency

A

Isolated IgA deficiency

In the Philippines, the most common is SIDS

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9
Q

Bubble boy disease

A

SCID

X-linked: most common form
AR: deficiency of adenosine deaminase

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10
Q

Deficient in AR SCID

A

Adenosine deaminase

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11
Q

Thrombocytopenia + eczema + recurrent infection

A

Wiskott-Aldrich Syndrome

X-linked
Treatment: BM transplant

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12
Q

Genetic deficiencies of complement system: C1

A

Hereditary angioedema

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13
Q

Genetic deficiencies of complement system: C2

A

SLE-like autoimmune disease

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14
Q

Genetic deficiencies of complement system: C5-C9

A

Membrane-Attack Complex (MAC)

Patients prone to neisserial infection

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15
Q

Which type of complement system is responsible for opsonization?

A

C3b

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16
Q

Which side of the gamma globulins is variable?

A

Amino side

Hypervariable: complementary binding sites

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18
Q

Which side of the gamma globulins is consant?

A

Carboxy side

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19
Q

Pentamer Ig?

A

IgM

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20
Q

Cells which have IgM as a surface marker?

A

B cells

21
Q

Arthrus reaction is what type of hypersensitivity?

A

Type III

22
Q

SCID, X-linked mutation?

A

Mutationi n gamma-chain subunit of cytokine receptors

23
Q

SCID, AR mutation?

A

Deficiency in ADA (adenosine deaminase)

24
Q

Ig that fixes complement?

A

IgM

25
Q

Earliest manifestation of ankylosing spondylitis?

A

Sacroilitis

27
Q

Immunoglobulin status in Wiskott-Aldrich syndrome?

A

Low IgM, normal IgG, high IgE and IgA

Patho (14 decks)

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