Immunology Flashcards

1
Q

Chronic granulomatous disease
shows the following clinical features EXCEPT:

a. Dermatitis
b. Otitis media
c. Acute suppurative infection
d. Hepatomegaly with abscess

A

c. Acute suppurative infection

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2
Q

A life threatening form of hemophagocytic
lymphohistiocytosis is commonly associated with this deficiency.

a. Chediak Higashi Syndrome
b. Leukocyte Adhesion Defect
c. Wisckott Aldrich Syndrome
d. Severe Combined
Immunodeficiency

A

a. Chediak Higashi Syndrome

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3
Q

Bruton tyrosine kinase protein is commonly associated with this type of immunodeficiency.

a. Chediak Higashi Syndrome
b. Leukocyte Adhesion Defect
c. Chronic Granulomatous
Disease
d. X-linked Agammaglobulinemia

A

d. X-linked Agammaglobulinemia

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4
Q

Leukocyte adhesion defect will have a significant leukocytosis of:

a. >22,000
b. >23,000
c. >24,000
d. >25,000

A

d. >25,000

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5
Q

The accelerated phase in Chediak- Higashi Syndrome is characterized by the following features EXCEPT:

a. High fever
b. Thrombocytopenia

The accelerated phase in Chediak- Higashi Syndrome is characterized by the following features
EXCEPT: *
a. High fever
b. Thrombocytopenia
c. Lympocytopenia
d. Shortened bleeding time

A

c. Lympocytopenia

d. Shortened bleeding time

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6
Q

A severe case of Myositis caused by Echoviruses is commonly associated with this primary deficiency.

a. Selective Ig A deficiency
b. X-linked Agammaglobulinemia
c. Common variable immunodeficiency
d. Severe combined Immunodeficiency

A

b. X-linked Agammaglobulinemia

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7
Q

Ataxia telangiectasia mutations are mapped to long arm of chromosome ?

a. 10
b. 11
c. 12
d. 13

A

b. 11

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8
Q

Lee, a 2-year old male presents with 4 episodes of pneumonia with 1 episode associated with blood culture growth of S. Pneumoniae since 6 months old. He also has frequent otitis media and sinusitis. He most likely has this deficiency .

a. Humoral
b. Cellular
c. Phagocytes
d. Complement

A

a. Humoral

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9
Q

Patients with T-cell defect will have this susceptibility to these group of infectious agents.

a. Encapsulated gram (+)
organisms
b. Catalase (+) organisms
c. Pyogenic organisms
d. Viruses, Mycobacterium

A

d. Viruses, Mycobacterium

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10
Q

A 2 week old managed as sepsis neonatorum with oral candidiasis, with absent tonsils and with markedly decreased lymphocytes will give you an initial diagnosis of:

a. Common variable deficiency
b. Severe combined immunodeficiency
c. Leukocyte adhesion defects
d. Chronic Granulomatous disease

A

b. Severe combined immunodeficiency

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11
Q

Dysmorphogenesis of these
pharyngeal pouches occurs in DiGeorge syndrome

a. 2nd and 3rd
b. 3rd and 4th
c. 4th and 5th
d. 5th and 6th

A

b. 3rd and 4th

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12
Q

A finding of angioneurotic edema will possibly have a deficient defense system involving the:

a. Antibodies
b. Cellular immunity
c. Phagocytosis
d. Complement system

A

d. Complement system

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13
Q

This clinical finding is suggestive of Wisckott-Aldrich Syndrome.

a. Neonatal seizures
b. Bleeding diathesis
c. Prolonged separation of umbilical cord
d. Prolonged bleeding post circumcision

A

d. Prolonged bleeding post circumcision

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14
Q

This immunodeficiency is commonly associated with phenytoin treatment.

a. Selective IgA deficiency
b. Hyper Ig E syndrome
c. X linked hypogammaglobulinemia
d. Ataxia Telangiectasia

A

a. Selective IgA deficiency

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15
Q

An initial presentation of a primary variable vessel vasculitis is :
a. oral ulcer
b. genital scar
c. anterior uveitis
d. erythema nodosum

A

a. oral ulcer

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16
Q

The following are TRUE of Hyper IgE syndrome EXCEPT:

a. Autosomal dominant
b. Gene on Stat 3
c. Fine facial features
d. Minimal trauma fractures

A

c. Fine facial features