Immunology

Question 1

Chronic granulomatous disease
shows the following clinical features EXCEPT:

a. Dermatitis
b. Otitis media
c. Acute suppurative infection
d. Hepatomegaly with abscess

Answer 1

c. Acute suppurative infection

Question 2

A life threatening form of hemophagocytic
lymphohistiocytosis is commonly associated with this deficiency.

a. Chediak Higashi Syndrome
b. Leukocyte Adhesion Defect
c. Wisckott Aldrich Syndrome
d. Severe Combined
Immunodeficiency

Answer 2

a. Chediak Higashi Syndrome

Question 3

Bruton tyrosine kinase protein is commonly associated with this type of immunodeficiency.

a. Chediak Higashi Syndrome
b. Leukocyte Adhesion Defect
c. Chronic Granulomatous
Disease
d. X-linked Agammaglobulinemia

Answer 3

d. X-linked Agammaglobulinemia

Question 4

Leukocyte adhesion defect will have a significant leukocytosis of:

a. >22,000
b. >23,000
c. >24,000
d. >25,000

Answer 4

d. >25,000

Question 5

The accelerated phase in Chediak- Higashi Syndrome is characterized by the following features EXCEPT:

a. High fever
b. Thrombocytopenia

The accelerated phase in Chediak- Higashi Syndrome is characterized by the following features
EXCEPT: *
a. High fever
b. Thrombocytopenia
c. Lympocytopenia
d. Shortened bleeding time

Answer 5

c. Lympocytopenia

Question 6

A severe case of Myositis caused by Echoviruses is commonly associated with this primary deficiency.

a. Selective Ig A deficiency
b. X-linked Agammaglobulinemia
c. Common variable immunodeficiency
d. Severe combined Immunodeficiency

Answer 6

b. X-linked Agammaglobulinemia

Question 7

Ataxia telangiectasia mutations are mapped to long arm of chromosome ?

a. 10
b. 11
c. 12
d. 13

Answer 7

b. 11

Question 8

Lee, a 2-year old male presents with 4 episodes of pneumonia with 1 episode associated with blood culture growth of S. Pneumoniae since 6 months old. He also has frequent otitis media and sinusitis. He most likely has this deficiency .

a. Humoral
b. Cellular
c. Phagocytes
d. Complement

Answer 8

a. Humoral

Question 9

Patients with T-cell defect will have this susceptibility to these group of infectious agents.

a. Encapsulated gram (+)
organisms
b. Catalase (+) organisms
c. Pyogenic organisms
d. Viruses, Mycobacterium

Answer 9

d. Viruses, Mycobacterium

Question 10

A 2 week old managed as sepsis neonatorum with oral candidiasis, with absent tonsils and with markedly decreased lymphocytes will give you an initial diagnosis of:

a. Common variable deficiency
b. Severe combined immunodeficiency
c. Leukocyte adhesion defects
d. Chronic Granulomatous disease

Answer 10

b. Severe combined immunodeficiency

Question 11

Dysmorphogenesis of these
pharyngeal pouches occurs in DiGeorge syndrome

a. 2nd and 3rd
b. 3rd and 4th
c. 4th and 5th
d. 5th and 6th

Answer 11

b. 3rd and 4th

Question 12

A finding of angioneurotic edema will possibly have a deficient defense system involving the:

a. Antibodies
b. Cellular immunity
c. Phagocytosis
d. Complement system

Answer 12

d. Complement system

Question 13

This clinical finding is suggestive of Wisckott-Aldrich Syndrome.

a. Neonatal seizures
b. Bleeding diathesis
c. Prolonged separation of umbilical cord
d. Prolonged bleeding post circumcision

Answer 13

d. Prolonged bleeding post circumcision

Question 14

This immunodeficiency is commonly associated with phenytoin treatment.

a. Selective IgA deficiency
b. Hyper Ig E syndrome
c. X linked hypogammaglobulinemia
d. Ataxia Telangiectasia

Answer 14

a. Selective IgA deficiency

Question 15

An initial presentation of a primary variable vessel vasculitis is :
a. oral ulcer
b. genital scar
c. anterior uveitis
d. erythema nodosum

Answer 15

a. oral ulcer

Question 16

The following are TRUE of Hyper IgE syndrome EXCEPT:

a. Autosomal dominant
b. Gene on Stat 3
c. Fine facial features
d. Minimal trauma fractures

Answer 16

c. Fine facial features