Immunology

Question 1

Example of failure of specificity of antigen

Answer 1

Acute rheumatic fever

Question 2

Hapten antigen

Answer 2

Has antiginicity
Lacks immunogenicity

Question 3

How hapten can be changed into complete antigen

Answer 3

Attaching it to a carrier protein

Question 4

Toxic shock syndrome due to

Answer 4

Superantigen.
Polyclonal activation of T helper cells

Question 5

E.g of superantigens

Answer 5

Staphylococcal enterotoxins.
TSST.1(Toxic shock syndrome toxin.
Streptococcal pyrogenic exotoxin.
Epidermolytic toxin

Question 6

Exact bond formation between antigen and antibody in

Answer 6

Hyper variable/hotspot/idiotype region

Question 7

IgM activates which complement pathway

Answer 7

Classical

Question 8

Agglutinating antibody

Answer 8

IgM

Question 9

Lyric antibody

Answer 9

IgM

Question 10

Opsonizing antibody

Answer 10

IgG

Question 11

Precipitating antibody

Answer 11

IgG

Question 12

Local/secretory/mucosal antibody

Answer 12

IgA

Question 13

Homocytotrophic antibody

Answer 13

IgE

Question 14

Microbes which have mannose on their surface

Answer 14

C2NS+L
Candida albicans
Cryptococcus neoformans
Neisseria
Salmonella
Listeria monocytogenes

Question 15

Classical pathway C3 convertase

Answer 15

C1C4bC2a

Question 16

Classical pathway C5 convertase

Answer 16

C1C4bC2aC3b

Question 17

Alternative pathway C5 convertase

Answer 17

C3bBbC3b

Question 18

Alternative pathway C3 convertase

Answer 18

C3bBb

Question 19

Lectin pathway C3 convertase

Answer 19

MBL,MASP1,MASP2,C4bC2a

Question 20

Lectin pathway C5 convertase

Answer 20

MBL, MASP1, MASP2, C4bC2aC3b

Question 21

Precipitation Reaction –ring test e.g.

Answer 21

1- streptococcal grouping by lancefield technique
2- Ascoli’s thermo precipitating test(Anthroax)

Question 22

Precipitation Reaction – flocculation test e.g.

Answer 22

Slide- VDRL test
Test tube- kahn test

Question 23

Microscopic agglutination test is gold standard for

Answer 23

Leptospirosis

Question 24

Diagnostic application of heterophile antigens

Answer 24

In serological test,e.g:
1- weil- felix reaction
2- paul bunnell test
3- cold aggulutination test and Streptococcas MG test

Question 25

Weil felix reaction 1- for 2-Antibody for: 3-Cross antigen:

Answer 25

1- typhus fever 2- rickettsial antigen 3- proteus antigen

Question 26

Paul- Bunnell test 1-for 2- antibody for 3- cross

Answer 26

1- infectious mononucleosis 2- epstein-barr virus 3- sheep rbc antigen

Question 27

Cold aggulutination test 1- for 2- antibody against 3- cross

Answer 27

1- primary atypical pneumonia 2- Mycoplasma pneumoniae 3- O blood group rbc

Question 28

Streptococcas MG test 1- for 2- antibody against 3- cross

Answer 28

1- primary atypical pneumonia 2- Mycoplasma pneumoniae 3- Streptococcas MG antigen

Question 29

Examples of antigen adjuvant

Answer 29

1- alum 2- mineral oil(paraffin) 3- freund's complete adjuvant 4- LPS/ lipopolysaccharide 5- mycobacterium bovis 6- toxoid (diphtheria toxoid and tetanus toxoid for Haemoplilus influenzae

Question 30

First antibody to be synthesized in fetal life

Answer 30

IgM

Question 31

Therapeutic use of mAb

Answer 31

Adalimumab and infliximab ab against TNF-alpha in rheumatoid arthritis

Question 32

mAb used against TNF-alpha in rheumatoid arthritis

Answer 32

Adalimumab, Infliximab