Immunology Flashcards
(33 cards)
Class II Antigens of the Major Histocampatibiliy System are expressed in which of the following cells? A. Microglias B. Red Blood Cells C. T Cells D. Natural Killer Cells
A. Microglias
All are cells that belong to the specific immune response (acquired) except A. Lymphocytes T B. Lymphocytes B C. Monocytes D. Plasma Cells
D. Plasma Cells
Maturation of T-Lymphocytes is most likely to occur in one of the following organs A. Thymus B. Bone Marrow C. Liver D. Kidney E. Secondary Lymph Nodes
A. Thymus
Interlukin-2 (T cell growth factor) is produced by which of the following cells listed below A. B Cells B. Both T and B Cells C. Monocytes D. Phagocytes E. T cells
Both T and B cells
What does gene therapy TNF in tumor infiltrating lymphocytes (TIL) do?
Allow the TIL to return to the tumor and produce locally high levels of TNF
Which marker or markers is present on cells which belong to lymphoid series that are important in innate immunity and could be used to specifically identify such cells in a flow cytometric analyzer? A. CD 3 and CD4 B. CD 3 and CD8 C. CD 14 and CD 38 D. CD 16 and CD 56 E. CD 19 and CD 20
D. CD 16 and CD 56
A superantigen is a bacterial product that
A. binds to B7 and CD28 costimulatory molecules
B. binds to the beta chain of TCR and MHC class II molecules of APC stimulating T cell activation
C. binds to the CD4 + molecule causing T cell activation
D. is presented by macrophages to a larger-than-normal number of T helper CD4 + lymphocytes
E. stimulates massive amounts of IgG synthesis because of its large size
B. binds to the beta chain of TCR and MHC class II molecules of APC stimulating T cell activation
Cytotoxic T cells induced by infection with virus A will kill target cells
A. from the same host infected with any virus
B. infected by virus A and identical at class I MHC loci to the cytotoxic T cells
C. infected by virus A and identical at class II MHC loci to the cytotoxic T cells
D. infected with any virus and identical at class I MHC loci to the cytotoxic cells
E. infected with any virus and identical at class II MHC loci to the cytotoxic cells
B. infected by virus A and identical at class I MHC loci to the cytotoxic T cells
Antigen recognition by the helper T-cell antigen receptor occurs after
A. Interaction with the CD8 molecule on the T cell
B. Peptide binding to the HLA-DQ molecule
C. Carbohydrate binding to the HLA-B27molecule
D. Carbohydrate binding to the HLA-DP molecule
E. Peptide binding to the HLA-B27molecule
B. Peptide binding to the HLA-DQ molecule
Functions of the thymus include all the following except A. Elimination of T cells that have low affinity for MHC class I molecules. B. Elimination of T cells that have high affinity for MHC class II molecules. C. Stimulation of T cells that have low affinity for MHC class I molecules. D. Stimulation of T cells that have low affinity for MHC class II molecules.
B. Elimination of T cells that have high affinity for MHC class II molecules.
IgG2 and IgA2 are examples of different A. Idiotypes B. Allotypes C. Genotypes D. Isotypes
D. Isotypes
A 12-year-old child is diagnosed with a T-cell lymphoma. The phenotype of the malignant cell matches that of normal progenitor cells that leave the bone marrow to enter the thymus. What cell surface molecules would you expect to find on the malignant cells? A. CD4-,CD8-, TCR-,CD3+ B. CD4-,CD8-, TCR+,CD3- C. CD4+,CD8+, TCR+,CD3+ D. CD4-,CD8-, TCR-,CD3- E. CD4+,CD8+, TCR+,CD3-
D. CD4-,CD8-, TCR-,CD3-
Which one of the following is correct about an IgG immunoglobulin molecule?
A. The constant heavy 2 domain binds to Cl complement molecules.
B. The constant heavy 1domain binds to antigen epitopes.
C. The variable light domain binds to cell receptors on cell membranes.
D. The constant heavy 3 domain binds to antigen epitopes.
E. The variable light domain binds to J chains
The constant heavy 2 domain binds to Cl complement molecules.
An active inflammatory reaction is occurring, and large numbers of neutrophils are being attracted to the inflammation site. Which one of the following is a major chemotactic factor involved in this reaction? A. IL-2 B. IgM C. C5a D. C3b E. Lysozyme
C. C5a
Complement binding site A. A B. B C. C D. D E. E
D. D
Interlukin-2 (T-cell growth factor) is produced by why of the following cells listed below? A. B cells B. Both T and B cells C. Monocytes D. Phagocytes E. T cells
E. T cells
Which immunoglobulin is the primary antibody in saliva, tears, and intestinal and genital secretions? A. IgG B. IgM C. IgE D. IgA E. IgD
D. IgA
All immune cells has a common ancestor which is: A. B cells B. T cells C. Monocytes D. Phagocytes E. Stem cell
E. Stem cell
Which of the following is a property of the innate immune response?
A. Has memory
B. It is specific for an antigen
C. Secondary responses to the same antigen are stronger
D. It is not specific for an antigen
E. Antibody against antigens can be highly variable
D. It is not specific for an antigen
Class II antigens of the Major Histocompatibility System are expressed in which one of the following cells? A. Alveolar macrophages B. Red blood cells C. T cells D. Natural killer cells
A. Alveolar macrophages
A\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ cannot elicit an immune response by itself and to achieve it requires its binding to a protein. A. Immunogen B. Hapten C. Peptide D. Allergen
B. Hapten
Which of the following hypersensitivity reactions causes systemic lupus erythematosus? A. Type-I B. Type-II C. Type-III D. Type IV
C. Type-III
Histamine is release in a type-I hypersensitivity reaction in which \_\_\_\_\_\_\_\_\_ participates? A. IgE B. IgG C. IgM D. IgA E. IgD
A. IgE
Evaluation of humoral immunity consists primarily of measuring the concentration of the following immunoglobulins: A. IgG B. IgG and IgM C. IgG, IgM and IgA D. IgG, IgM, IgA, and IgE E. IgG, IgM, IgA, IgE and IgD
C. IgG, IgM and IgA
