Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Pathology Past Paper Question > Immunology > Flashcards

Immunology Flashcards

(53 cards)

Start Studying
1
Q

What antibody do you get in hypothyroidism

A

Anti-thyroglobulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What antibody do you get in Sjogren’s syndrome (dry eyes, dry mouth, dry skin, vaginal dryness, dry mucous membranes)

A

Anti-Ro

Anti-La (more specific)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What antibody do you get in droopy eyelid which is fatiguable (Myasthenia gravis)

A

Anti-acetylcholine receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What antibody do you get in tight lips (CREST)

A

Anti-Centromere

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What antibody do you get in: swollen joints of the hand, x-ray shows erosive joint changes in keeping with rheumatoid arthritis

A

Anti-CCP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Biological treatment for: Ankylosing spondylitis

A

Etanercept

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Biological treatment for: resistant psoriasis

A

Etanercept

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Biological treatment for: Chronic granulomatous disease treatment

A

IFN gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Biological treatment for: osteoporosis

A

Denosumab

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Biological treatment for: hyperIgM syndrome

A

Human Ig

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What immune cell resides in bone marrow until migrates to site of injury. Oxidative and non-oxidative killing. Dies once job’s done.

A

Neutrophils

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Subset of lymphocytes that express Foxp3 and CD25, mature in the thymus

A

Treg cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What immune cells detects antigen in the periphery and moves to lymph nodes?

A

Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What immune cell detects MHC1 and kills virus infected/cancer cells. Is inhibited by MHC I

A

NK cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What immune cells is targeted by HIV?

A

CD4+

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Which is a naturally occurring cytokine that is able to inhibit HIV fusion to CD4+ T-lymphocytes?

A

MIP-1alpha

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What type of hypersensitivity (Gel and Coombs classification) is myasthenia gravis and what cell?

A

Type II

B/plasma cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

IPEX affects what type of immune cell?

A

Treg

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What is the definition of herd immunity threshold?

A

1 –1/R0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Name 1 of the 3 characteristics of Influenza A that could cause a pandemic?

A

Novel antigenicity
Efficient replication in human airway
Efficiency viral transmission between people

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

16 year old girl has pleuritic chest pain, joint pain, positive ANA and Anti-Sm, no liver enzyme derangement, raised ESR?

A

SLE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Chimeric antigen receptor T-cell therapy against CD19: what type of haematological malignancy does it target?

Study These Flashcards
A

B cells (CD19 is present on B cells)

23
Q

Child with low calcium, cleft palate, low T cells?

Study These Flashcards
A

DiGeorgesyndrome

24
Q

Ankylosing spondylitis - they’ve tried NSAID and TNF inhibitor?, what else can you target?

25
45yo woman with autoimmune diseases, low IgM, IgA and IgE; full blood count is normal?
Common variable immunodeficiency
26
Which immunoglobulin is found in mucosa
IgA
27
What cell goes wrong in IPEX?
Treg cells
28
Antibody for Graves Disease?
stimulatory anti-TSH receptor Ab
29
Nivolumab is a PD1 inhibitor, what cells does it target?
T cells
30
PCSK9 inhibitor - evolucumab, what does it halve?
LDL levels
31
Which of the following vaccine is a polysaccharide and conjugate vaccine?
Strep pneumonae
32
What Type Hypersensitivity causes serum sickness?
Immune complex mediated (type 3)
33
What is the effect of the gene mutation in familial mediterranean fever?
Increased IL-1 production
34
Which cell is activated by inhibitory receptors that bind MHC I
NK cells
35
Cells which produce Ig and reside in bone marrow
Plasma cells
36
Antibody involved in: Hashimoto's Thyroiditis
anti-TPO antibodies
37
Antibody involved in: rheumatoid arthritis
Anti-Cyclic Citrullinated Peptide Antibodies | Rheumatoid Factor
38
Immunodeficiency with common gamma chain problem?
X linked SCID
39
Reactivation of a virus following a transplant.
Epstein Barr Virus
40
Mother is a donor for kidney to a child, what is the max number of mismatches possible with HLA class I? 
6? or 2?
41
Sacroiliitis, HLA B27 positive
Ankylosing Spondylitis
42
Previous IVDU man is given Rituximab - CHOP treatment for Non-Hodgkin’s lymphoma. He later 8 months later develops fulminant liver failure and dies. Why?
rituximab can cause reactivation of hepatitis B which typically causes acute hepatocellular injury that can be severe and lead to acute liver failure
43
Which type of cell does Rituximab target?
(CD20 expressed on) Mature B cell
44
Treatment for CLL with p53 mutation. What is the first line treatment?
Ibrutinib
45
Treatment for CML?
Imatinib
46
What is the usual prophylaxis for allograft rejection?
Prednisolone AND Calcineurin inhibitors are commonly used such as: Tacrolimus Ciclosporin Cell cycle inhibitors: Mycofenolate mofetil Azathioprine (old drug) Targeting TCR (These cause apoptosis of T cells): Anti-CD3 antibody (OKT3) Anti-thymocyte globulin
47
Which allergy is more likely to present in child than adult? 
Egg
48
Biological treatment for rheumatoid arthritis?
Antibody against IL6 receptor - Tocilizumab Anti-TNFa Antibodies - infliximab, adalimumab, certolizumab, golimumab TNF-alpha antagonist - Etanercept JAK inhibitor - tofacitinib Anti-CD20 antibodies - Rituximab
49
HIV - what natural antibody against, which confers protective immunity against HIV?
Anti-gp120 and anti-gp41 (Nt) antibodies
50
Name the main class of drug used to treat HIV
2x nucleoside reverse transcriptase inhibitor | 1x non-nucleoside reverse transcriptase inhibitor or protease inhibitor
51
Immune therapy for Granulomatous | Disease
Interferon gamma
52
Antibody against: SLE
anti ds-dna
53
Kupffer cell (and other specialised macrophages) are all types of
macrophages

Pathology Past Paper Question (3 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions