Immunology

Question 1

What is the SLE auto antibody?

Answer 1

ANA

Question 2

What is the leukocyte adhesion deficiency mechanism?

Answer 2

Deficiency in CD18 (B2 integrin)

Question 3

Cell type involved in Type 4 hypersensitivity?

Answer 3

T cells

Question 4

What is the effect of leukotriene on neutrophils?

Answer 4

Chemotaxis (attracts neutrophils to the site of infection)

Question 5

What is the major positive acute phase protein in cats?

Answer 5

Serum amyloid A

Question 6

What is the mutation responsible for leukocyte adhesion deficiency?

Answer 6

CD18+

Question 7

CD markers of B lymphocyte?

Answer 7

CD21, CD45, CD79

Question 8

Main cytokine secreted by natural killer cells?

Answer 8

IFN-gamma

Question 9

Cytokines responsible for fever?

Answer 9

IL-1
IL-6
TNF-alpha

Question 10

What does TLR4 recognize?

Answer 10

LPS in GM - bacteria

Question 11

Name the mechanism of the four hypersensitivity reactions:

Answer 11

Type I: reaction mediated by IgE antibodies (immediate)
Type II: antibody-depended cell-mediated cytotoxicity
Type III: reaction mediated by immune complexes
Type IV: delayed reaction mediated by cellular response

Question 12

Where are natural killer cells produced?

Answer 12

Bone marrow

Question 13

What antibodies are present in systemic lupus?

Answer 13

ANA, CD4, T Cells, and B Cells

Question 14

What is the Western Blot test used for?

Answer 14

Detects specific protein

Question 15

What Th is associated with eosinophils?

Answer 15

Th2

Question 16

What is the first step in the classical complement cascade?

Answer 16

C1 binds Ag-Ab

Question 17

What cytokines are involved in fever?

Answer 17

IL-1, IL-6, TNF-a

Question 18

What cell decreases with FIV/FeLV?

Answer 18

CD4+ (aka T Helper cells)

Question 19

CD for B cells?

Answer 19

CD79a, CD21

Question 20

What Ig is in upper resp tract?

Answer 20

IgA

Question 21

In what cells does FIV virus replicate?

Answer 21

T cells

Question 22

What cytokine is produced by NK cells?

Answer 22

IFN-γ

Question 23

What is major histocompatibility complex (MHC) class II associated with?

Answer 23

CD4 lymphs [aka CD4 T cells (classical “helper” T cells)]

Question 24

How do CD8+ lymphs kill cells?

Answer 24

Perforins

Question 25

Which WBC is responsible for removing foreign material from the pulmonary alveoli?

Answer 25

Alveolar macrophages

Question 26

What is the function of class II MHC molecules?

Answer 26

MHC II molecules are involved in the exogenous pathway and are expressed primarily on antigen-presenting cells; bind to peptides taken in from outside of the cell ANY peptide in the endosome can be loaded on to class II. Self proteins from the extracellular fluid, proteins found in the cell membrane that are brought into the endosome, and pathogen-derived proteins.