Immunology Adoptive Cellular Immunotherapy Flashcards
1
Q
A
2
Q
A
3
Q
A
4
Q
A
5
Q
A
6
Q
A
7
Q
A
8
Q
[…]
A
D
9
Q
[…]
A
E
First gen only CD3 (no costim)
Second gen includes CD3 and CD28 (1 costim)
Third gen includes CD3, CD28 and CD137 (2 costim)
10
Q
[…]
A
A&D
Not C!
11
Q
A
C
12
Q
[…]
A
D
Keyword is NOT
13
Q
3 ways NK can effect its function?
A
3 ways NK can effect its function?
1) CDC (Cell mediated direct cytotoxicity)
2) ADCC (Ab Dependant Cellular Cytotoxicity)
3) **Cytokine-mediated function **
14
Q
5 ways a tumour may escape immunity?
A
5 ways a tumour may escape immunity?
- Loss of tumour specific antigens
- Loss or reduced expression of MHC class I
- Secretion of immunosuppressive factors (e.g. TGF β) from the tumour
- Expression of inhibitory cell surface proteins eg CTLA-4, PD-L1
- Promote other cellular suppressors of immune responses, such as regulatory T cells
15
Q
Concept of adoptive cellular immunotherapy?
A
Concept of adoptive cellular immunotherapy?
1) Collect immune cells from a patient and grow in the lab
2) put back the cultured immune cells into the patient to help immune system fight disease