Immunology/Chemo Concepts

Question 1

107) What is chemotherapy?

Answer 1

The management of malignant disease through chemical agents

Question 2

108) What is meant by cell-cycle specific and cell-cycle nonspecific chemotherapy?

Answer 2

cell-cycle specific: “schedule dependent” produce greater cell kill when given in multiple repeated doses

cell-cycle nonspecific: “dose dependent” produce greater cell kill when given in single high dose bolus

Question 3

109) What are colony stimulating factor medications used for? What are examples of each kind and which cells do they stimulate?

Answer 3

treats bone marrow suppression in cancer patients, ESRD and severe immunocompromised (AIDS).
EPOETIN ALPHA- anemia (stimulate RBC)
FIGRASTIM- neutropenia (stimulate WBC)
OPRELVEKIN- thrombocytopenia (stimulate platelets)

Question 4

110) What is the biggest ADR for any client on immunosuppressive therapy?

Question 5

111) What does the term DMARDS stand for? What clients benefit from DMARDS?

Answer 5

-Disease modifying antirheumatic drugs

-Rheumatoid Arthritis

Question 6

112) What are some examples of monoclonal antibody medications? List the drug and what disorder they are best for?

Answer 6

ADALIMUMAB
GOLIMUMAB
INFLIXIMAB

Question 7

113) What is tofacitinib? What route is it given?

Answer 7

Xeljanz (brand name), used as monotherapy or when MTX or other non-biologics failed
-taken orally

Question 8

114) What is methotrexate? What are some disorders it is used to treat?

Answer 8

DOC, chemo agent that decreases inflammation by increasing adenosine levels

Question 9

115) What is the most common antirejection medication? What class does it belong to?

Answer 9

-Cyclosporine

-Calcineurin inhibitor