Immunology High Yields Flashcards
(48 cards)
1
Q
CD2
A
T Cell
2
Q
CD3
A
T Cell
3
Q
CD4+
A
Helper T Cell
4
Q
CD8+
A
CTLS
5
Q
CD28
A
Binds B7 on APC
T cells
6
Q
CD40L
A
Binds CD40 to activate B cells or macrophages
T Cells
7
Q
TCR
A
T Cells
8
Q
CD19
A
B Cells
9
Q
CD20
A
B Cells
10
Q
CD21
A
B Cells
11
Q
CD40
A
Binds CD40L
B Cells
Macrophages
12
Q
B7
A
Binds CD28
B Cells
Macrophages
13
Q
MHC Class I and II
A
B cells (both) Macrophages (both) NK cells (MHC I only)
14
Q
CD14
A
Macrophages (endotoxin receptor)
15
Q
CD16
A
Macrophages (Fc-gamma) receptor
NK Cells
16
Q
CR1
A
Macrophages (C3b receptor)
17
Q
CD56
A
NK Cells
18
Q
CD55
A
RBCs, WBCs, Platelets
19
Q
CD59
A
RBCs, WBCs Platelets
20
Q
X-Linked Immunodeficiencies
A
"Missing WBCs" Hyper-IgM, Wiscott-Aldrich syndrome, Burton's agammglobulinemia, Chronic grandulomatous disease, Severe combined immunodeficiency
21
Q
Anaphylactic Reaction Following Blood Transfusion
A
IgA deficiency
IgE against Fc portion of IgA heavy chain
22
Q
HLA-A3
A
Hemochromatosis
23
Q
HLA-B27
A
Psoriatic arthritis, Ankylosing spondylitis, Inflammatory bowel disease arthritis, Reactive arthritis (Reiter syndrome)
24
Q
HLA-DQ2/DQ8
A
Celiac disease
25
HLA-DR2
MS, hay fever, SLE, Goodpasture
26
HLA-DR3
Diabetes mellitus type 1, SLE, Graves, Hashimoto
27
HLA-DR4
Rheumatoid arthritis, diabetes mellitus type 1
28
HLA-DR5
Pernicious anemia--> B12 deficiency; Hashimotos
29
IL-1
Secreted by macrophages
Fever, acute inflammation; Activates endothelium to express adhesion molecules; Induces chemokine secretion to recruit WBCs
30
IL-6
Secreted by macrophages
| Fever, stimulates production of acute phase proteins
31
IL-8
Secreted by macrophages
Major chemotactic factor for neutrophils
"Clean up in aisle 8"
32
IL-12
Secreted by macrophages
| Induces differentiation of T cells into Th1 cells; Activates NK cells
33
TNF-alpha
Secreted by macrophages
| Mediates septic shock; Activates endothelium; Causes WBC recruitment; Vascular leak; Causes cachexia in malignancy
34
IL-2
Secreted by all T cells
| Stimulates growth of helper, cytotoxic and regulatory T and NK cells
35
IL-3
Secreted by all T cells
| Supports growth and differentiation of bone marrow stem cells; Functions like GM-CSF
36
Interferon-gamma
Secreted by Th1 cells
Secreted by NK cells in response to IL-12 from macrophages; Stimulates macrophages to kill phagocytosed pathogens; Also activates NK cells to kill virus infected cells; Increases MHC expression and antigen presentation by all cells
37
IL-4
```
Secreted by Th2 cells
Induces differentiation into Th2 cells; Promotes growth of B cells; Enhances class switching to IgE and IgG
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38
IL-5
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Secreted by Th2 cells
Promotes differentiation of B cells; Enhances class switching to IgA; Stimulates growth and differentiation of eosinophils
```
39
IL-10
Secreted by Th2, Treg cells
Modulates inflammatory response; Decreases expression of MHC class II and Th1 cytokines; Inhibits activation of macrophages and dendritic cells;
Attenuate immune response
40
TGF-beta
Attenuates immune response
41
T Cell Proteins
TCR, CD3 (associated with TCR for signal transduction), CD28 (binds B7 on APC)
42
Helper T Cell Proteins
CD4, CD40L
43
Cytotoxic T Cell Proteins
CD8
44
Regulatory T Cell Proteins
CD4, CD25
45
B Cell Proteins
Ig (binds antigen); CD19, CD20, CD21 (receptor for EBV), CD40, MHC II, B7
"you can drink beer at the bar when you are 21" - EBV receptor is CD21
46
Macrophage Proteins
CD14 (binds LPS), CD40, MHCII, B7, Fc and C3b receptors (enhance phagosytosis)
47
NK Proteins
CD16 (binds Fc of IgG), CD56 (unique marker)
48
Hematopoietic Stem Cell Proteins
CD34
