Immunology Hypersensitivity

Question 1

Which of the following doesn’t describe hypersensitivity?
A) exaggerated immune responses to harmless environmental antigens
B) exaggerated immune responses to infections
C) inappropriate immune response to auto-antigens
D) appropriate response to an antigen

Answer 1

D

Question 2

What type is cytolytic hypersensitivity?

Answer 2

Type 2

Question 3

What type is anaphylactic hypersensitivity?

Answer 3

Type 1

Question 4

What type is immune-complex mediated hypersensitivity?

Answer 4

Type 3

Question 5

What type is delayed hypersensitivity?

Answer 5

Type 4

Question 6

What type is cell mediated hypersensitivity?

Answer 6

Type 4

Question 7

What type is immediate hypersensitivity?

Answer 7

Type 1

Question 8

Penicillin allergy is what type

Answer 8

1

Question 9

What antibody mediates type 1?

Answer 9

IgE

Question 10

Cells of type 1

Answer 10

Mast cells and eosinophils

Question 11

——————— is when a patient forms large amounts of IgE to certain harmless antigens instead of forming a low amount ?

Answer 11

Sensitisation type 1

Question 12

What kind of receptor do IgE molecules bind to ?

Answer 12

fC receptors

Question 13

T/F: 1st exposure to an allergen = sensitization of Mast cells & Basophils

Answer 13

True

Question 14

What occurs in the re exposure stage of type 1 ?

Answer 14

Antigen binds 2 adjacent IgE molecules on
mast cells (cross-linking)

Degranulation of mast cells
release granules and mediators

Question 15

Describe Preformed mediators:

Answer 15

Histamine and platelet activating factor (PAF) ◦
Responsible for symptoms seen during the Early phase, (within 15-20 minutes of exposure to the allergen).

Question 16

Describe Newly formed mediators:

Answer 16

leukotrienes and prostaglandins, take several hours to be synthesized, typically occurs 5-6 hours after allergen contact symptoms seen during the Late phase are the same as those of the early phase, but persist longer.

Question 17

T/F: late phase can lead to tissue damage due to hydrolytic enzymes

Answer 17

False late phase

Question 18

Which of the following is a symptom of systemic anaphylaxis
A) urticaria
B)conjunctivitis
C) bronchoconstriction
D) Bronchial asthma

Answer 18

C

Question 19

T/F: Systemic anaphylaxis occurs on sensitisation to a harmless antigen ie insect venom

Answer 19

False occurs on re exposure

Question 20

How to diagnose type 1 ?

Answer 20

• skin test
• measurement of serum levels

Question 21

First line of management of type 1 (excluding anaphylactic shock) ?

Answer 21

Avoidance

Question 22

Type 2 hypersensitivity antibodies ?

Answer 22

IgG and IgM

Question 23

Type of Hypersensitivity that reacts to cell bound antigens ?

Answer 23

Type 2

Question 24

ADCC is a mechanism of which type ?

Answer 24

2

Question 25

Complement activation is a mechanism of which type ?

Answer 25

2

Question 26

Opsonisation of target cell is a mechanism of which type ?

Answer 26

2

Question 27

Altered signalling is a mechanism of which type of hypersensitivity?

Answer 27

Type 2

Question 28

Transfusion reactions are examples of which type of hypersensitivity

Answer 28

2

Question 29

Hemolytic disease of the newborn is an example of which type of hypersensitivity?

Answer 29

Type 2

Question 30

Drug reactions are which type of hypersensitivity

Answer 30

Type 2

Question 31

Autoimmune hemolytic anemia Type

Answer 31

2

Question 32

Graves’ disease is which type

Answer 32

2

Question 33

T/F: small insoluble immune complexes may escape phagocytosis

Answer 33

Soluble

Question 34

Escaped immune complexes are usually found in :

Answer 34

Sites of turbulence like joints and kidneys

Question 35

Post-streptococcal glomerulonephritis is an example of

Answer 35

Type 3

Question 36

Systemic lupus erythematosis is a what type

Answer 36

3

Question 37

Which if the following is not a diagnostic mechanism for type 3 hypersensitivity? A) tissue biopsies for deposits of Ig and complement by immunofluorescence. B)depleted immune complexes in serum C) detection of immune complexes in serum D) depleted serum complement

Answer 37

B

Question 38

Which type of hypersensitivity is not antibody mediated ?

Answer 38

Type 4

Question 39

Main cell in type 4 hypersensitivity?

Answer 39

Th1

Question 40

Which type of hypersensitivity requires previous exposure ?

Answer 40

All

Question 41

What Th1 sectretion causes the activation of macrophages?

Answer 41

IFN-γ

Question 42

Tuberculin skin test (TST) is type

Answer 42

4

Question 43

T/F:A positive reaction to the Tuberculin skin test is erythema of the area

Answer 43

Induration not erythema

Question 44

Granulation is what type?

Answer 44

4

Question 45

Contact dermatitis is what type ?

Answer 45

4

Question 46

Skin patch test is for what disease?

Answer 46

Contact dermatitis

Question 47

Skin test is for what disease ?

Answer 47

Type one hypersensitivity

Question 48

Insulin dependent diabetes type

Answer 48

4