Immunology serology Flashcards
(29 cards)
Genes for light and heavy chains are found on what chromosomes respectively? A. Chromosome 2, 4 and 6 B. Chromosome 2, 22 and 14 C. Chromosome 4, 6 and 14 D. Chromosome 4, 22 and 16
B.
Which of the following IgG subtype cannot cross the placenta? A. IgG1 B. IgG2 C. IgG3 D. IgG4
B.
Which of the following IgG subtype cannot activate the complement system? A. IgG1 B. IgG2 C. IgG3 D. IgG4
D.
Which of the following surface antigens points to a mature thymocyte? A. CD34+, TdT+ B. Surface CD3+ C. TdT (-), CD1 (-), CD3+ D. CD1 +, TdT+, CD5+
C.
What is the normal ratio of CD4:CD8 count? A. 2:1 B. 1:2 C. 4:1 D. 1:4
A.
Which of the following is true regarding natural killer cells?
A. They express TCR and Ig
B. They express CD3
C. They represent 10% of peripheral blood lymphocytes
D. They express CD16 and CD38
C.
Remarks: CD3 - mature T cells; TCR and Ig are not expressed in NK cells. NK cells express CD16, CD56 and CD57.
Class II genes encoding HLA class II antigens are found in the following except. A. B cells B. Macrophages C. activated T-cells D. Platelets
D.
Remarks: Class I - all nucleated cells and platelets (rbcs have minimal Class I).
The chance of having an HLA-identical sibling with two siblings is how many percent? A. 25% B. 45% C. 60% D. 75%
B. Remarks: 1 sibling - 25% 2 siblings - 45% 3 siblings - 60%
Which of the following HLA subtype is protective of insulin-dependent diabetes mellitus? A. HLA-DR2 B. HLA-DR3 C. HLA-DR4 D. HLA-B27
A.
Remarks: HLA-DR3 and 4 are associated with IDDM.
The following autoimmune diseases are more common in women, except? A. SLE B. Primary biliary cirrhosis C. Ankylosing spondylitis D. Graves Disease
C.
Remarks: it is more common in men.
This infection in particular is associated with the onset of ankylosing spondylitis? A. Coxsakie B virus B. Hepatitis B infection C. Klebsiela pneumonia D. Malaria
C.
Remarks: Coxsakie B is assoicated with IDDM and HBV with PAN.
With a patient suspected with sarcoidosis, there is elevation of this laboratory finding and is extremely useful test in the diagnosis. A. LDH B. ACE C. AST D. ALT
B.
Which serum autoantibody is highly specific granulomatosis polyangitis and is often used to monitor this disease? A. Myeloperoxidase B. p-ANCA C. Anti-mitochondrial antibodies D. Anti-proteinase 3
D.
Remarks: Granulomatous polyangitis is Wegeners granulomatosis. c-ANCA is also called Anti-proteinase 3 (PR3).
This serum autoantibody is highly specific and highly sensitive for Hashimoto disease. A. Anti-endomysial B. Anti-GBM C. Anti-microsomal D. Anti-PM1
C.
Remarks: Anti-endyomysial is for celiac sprue and dermatitis herpetiformis.
This disease is characterized by fulminant and often fatal immune response to Epstein-Barr virus (EBV) infection inducing a hemophagocytic syndrome. A. Wiskott-Aldrich syndrome B. Duncan disease C. Louis-Bar syndrome D. Job syndrome
B
Remarks: Louis-Bar syndrome is also known as ataxia-telangiectasia.
Chronic granulomatous disease are often associated with what blood group phenotype? A. McLeod B. Lutheran C. Lewis D. Bombay
A.
Remarks: McLeod - very weak expression of Kell antigens
This specific anti-mitochondrial antibody is associated with primary biliary cirrhosis. A. Anti-M1 B. Anti-M2 C. Anti-M5 D. Anti-M7
B. - M2
The following drugs are associated with drug-induced lupus, except. A. isoniazid B. procainamide C. hydralazine D. methyldopa
D.
Remarks: Methyldopa (aldomet) associated with autoimmune hemolytic anemia (warm type).
HLA-DR4 associated with hydralazine
HLA-DR6 associated with procainamide
All are Immune complex mediated type of hypersensitivity, except. A. Henoch-Schonlein purpura B. Polyarteritis nodosa C. Acute rheumatic fever D. Post streptococcal glomerulonephritis
C.
Remarks: acute rheumatic fever - antibody cross reacts with myocardial antigen.
All are T-cell mediated type of hypersensitivity, except. A. Multiple sclerosis B. Insulin-resistant diabetes C. Type 1 DM D. Inflammatory bowel disease
B.
Remarks: Insulin-resistant DM is type 2 because the target is the insulin receptor.
Take note: Type 2 - acute rheumatic fever; Type 3- post strep glomerulonephritis; Type 4 - rheumatic arthritis.
The following statements regarding antithyroid antibodies are true, except.
A. Indirect immunofluorescence with anti-microsomal antibody highlight the follicular epithelium.
B. Indirect immuofluorescence with anti-thyroglobulin antibody highlight the colloid.
C. Hashimoto thyroiditis is positive for anti-microsomal, anti-thyroglobulin and long-acting thyroid stimulating (LATS) antibodies.
D. Graves disease is positive for LATS antibodies.
C.
Remarks: Hashimoto is positive for anti-microsomal and anti-thyroglobulin only and negative for LATS.
Autoimmune pancreatitis is associated with what particular IgG subtype? A. IgG1 B. IgG2 C. IgG3 D. IgG4
D. G4
Which of the following IgG subtype is the most predominant? A. IgG1 B. IgG2 C. IgG3 D. IgG4
A. G1
True or false. Indirect Coombs Test can detect complement proteins?
False - because complement proteins are bound proteins and can only be detected on Direct Coombs Test.
