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Immunopathology Flashcards

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1
Q

These are found at the surface f cells that contribute to the protective functionof the immune system

A

Fc receptors

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2
Q

Most important for antigen presenting cells for initiating primary immune response against protein antigens

A

Dendritic cells:

Location- under epithelia- entry site of antigensand interstitia of tissues where Ag maybe produced

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3
Q

Tyes of dendritic cells

A

Interdigitating/ simple dendritic
Langerhans cells
Follicular

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4
Q

For,ation of preformed antibody causing ADCC due to previous sensitization thru transfusion, pregnancy

A

Hyperacute rejection

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5
Q

Cellular infiltrates with both CD4 and CD8

A

Acute cellular rejection
Primarily T cell mediated cytotoxic damage
Density of infiltrate and extent of parenchymalndamage determine severity

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6
Q

Intimal fibrosis and ischemia in organ transplantation

Thickened amd fibrotic

A

Chronic rejection

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7
Q

In gvd what organs are most commonly involved

A

Liver intestine skin

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8
Q

In liver tranplant, is HLA an impt procedure

A

No,nthe size of organ matters

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9
Q

Where do you usually see the inflammation in tranplant

A

In portal tract area

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10
Q

Two modes ofnrejection in heart transplant

A

Acute cellular and acute vascular rejection

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11
Q

Vascular rejection in heart transplant

A

Mainly seen in small arteries- vasculitis

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12
Q

Would it help to give high immunosuppressive drug for acute heart transplant

A

No, dahil hindi atabtinatargetbyung vascular tissue

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13
Q

What is containedin the host cell in tranplant rejection? Ab or Ag?

A

Recipient has the antibody that will cause the immune response

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14
Q

Hypersensitivity reactions involved in autoimmunity

A

Primarily 2 and 3

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15
Q

In general, the higher, this is, the worse the disease, seen in manybautoimmune disease

A

Antinuclear antibodies

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16
Q

Characteristic staining of ANA as homogenous diffuse

A

Not very specific for anything

All nuclear element is antigenic

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17
Q

Characteristic staining of ANA as speckled

A

Antibody to extractable nuclear antigens, mixed connective tissue disease

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18
Q

Characteristic staining of ANA as nucleolar

A

Seen in progressive systemic sclerosis

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19
Q

Characteristic staining of ANA as rim

A

SLE

Against double stranded DNA

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20
Q

Substrate for dSDNa test

A

Crithridia organism

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21
Q

Characteristic p,attern of ENA

A

Speckled

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22
Q

Seen in progressive systemic sclerosis (scleroderma)- fluorescence

A

Nucleolar pattern

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23
Q

What is the endpoint usual disease of SLe patients

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A

Renal complication

24
Q

A benign SLE with skin involvement, ANA positive in only a third

Study These Flashcards
A

Discoid lupus erythematosus

25
Histologically what is seen in the skin pf the SLE patient
Vasculitis and dermal inflammatory infiltrates At the dermoepidermal junction Lytic vasculization
26
If positive vacuolization in the uninvolved skin in fluorescence staining in the dermoepidermal junction
SLE
27
Lesion is limited on the site where you have the lesion
Discoid
28
What is the specific antigen that the antibody develops in SLE
Cardiolipin Interferes woth coagulationnassays leading to thrombosis Lupus anticoagulant
29
Seen in the spleen of patients with SLE
Periarteriolar (onion skin)
30
2 most notorious autoimmune disease
SLE | PSS/ sclerodoma
31
A wastebasket category for patients who do not clearly fit into other categories
Mixed CT disease | Related to speckled pattern of failure to name it haha
32
Antinuclear antibody specific for sclerodoma
Scl-70
33
Serologically suggested by the presence of anti centromere antibody
Limited sclerodoma/ CREST
34
What is seem on the skin of scleroderma
Shiny, inelastic, sclerodactyly | Note cheilosis
35
Histological fincding in scleroderma
Firbrosis and chronic inflammatory infiltrates, thickened fibrocollagenous tissue
36
Worst form of scleroderma
Diffuse scleroderma associated with SCl70 Findings: CREST, rebal arterial intimal thickening and proliferation, lungs: diffuse alveolar fibrosis, skin fibrosis- morphea
37
Symmetricla inflammation of slkeletal muscle with weakness, sometimes associated with skin rash, associated Ab against nuclear antzigen, heliotropic rash at the upper eyelid
Polymyositis- dermatomyositis | With some forms of malignancy
38
Dry eyes, dry mouth: lacrimal and salivary involvement by lymphocytic infiltration, fobrosis and destruction by CD4+ cells helping in antibody reaction
Sjogren's syndrome
39
Encompass lacrimal amd salivary duct
Mikulicz syndrome | Seen in Sjogren
40
Males primarily affected disease bu inheritance occurs in x-linked recessive pattern
Bruton's dosease On long arm of xchromosome Mutation in production of tyrosine kinase Infants observed with multiple infections (Haemophilus and Staph) particularly on skin and lung, bcell absent, tcell intact
41
Field defect of 3rd and 4th pharyngeal puch in utero during organogenesis in the 1st trimester of pregnancy
DiGeorge syndrome Specific deletion of long arm of chromosome 22 In complete digeorge: normal level b cells, normal immunoglobulin, diminished T cells: fungal and viral infections (insoluble) and some parasites
42
Partial di george syndrome
SIight decrease i peripheral T lymphocytes | Increased infections, aplasia of parathyroid gland: life threatening hypocapcemia
43
Failure development both humoral and cell mediated
SCID Major variants: Xlinked and autosomal recessive- lack enzyme adenosine deaminase ( handle more bacterial infection, develop severe resp tract infection w/ pneumocystis carinii)
44
Wiskott aldrich triad
Immunodefeciency, thrombocytopenia, eczema Express little cd43 Children are predisposed
45
Genetic defect on chromosome 11 long arm, breakage of chromosom 7 and 14 High risk neoplasia, marked sensitivity to radiation
Ataxia - Telangiectasia
46
Triad of telangiectasia
Cerebellar ataxia, mucocutaneous telangiectasis, recurrent respiratory tract infxn Symptom usually benign bet 9 mo and 2 years of age Particularly Ige and IgA
47
Failure of Iga to transform to plasma cell
Selective Iga defeciency
48
In NK cells , killing is dependent on cell tomcell contact mediated by these two
IL- 12 and interferon
49
ADCC, the ability if IgG targetbcells to lyse is due to
CD 16 - secrete cyrokines such as IFN gamma - enhances NK cell killing
50
Where is MHC located
Chromosome 6
51
Mechanism of type II hypersensitivity reaction (3)
Phagocytosis and opsonization Inflammation Cellular dysfunction/ stimulation
52
Good pasteur syndrome is what type of Type II hypersensitivity reaction?
Inflammation | Deposited on basement membrane of glomerulus
53
Antibodies against cell surface that disregulates its function without causing cell injury or inflammation
Cellular dysfunction / stimulation Dys- myasthenia, pernicious anemia Stim- grave's dis
54
Type of hypersensitivity reaction wherein the sum complement is reduced because it is used up, and there is a marked vasculitis
Type III
55
(3) pathogenesis of systemic immune disease
Ag-Ab complex formed in circulation Deposition of immune complexes in var tissue Inflammation because of deposition of ICs
56
Type of immune complex disease of farmer's lung
Local immune complex | Arthus
57
Syndrome which involves specific deletion of long arm chromosome 22 (22q11) wherein there is a field defect on the 3rd and 4th pharyngeal pouch
DiGeorge syndrome

Pathology (1 decks)

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