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immunopath > Immunopathology Awkwards > Flashcards

Immunopathology Awkwards Flashcards

(52 cards)

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1
Q

HLAB4 is a haplotype of this arthritis.

A

Rheumatoid Arthritis

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2
Q

HLA-DRB1

A

Rheumatoid Arthritis.

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3
Q

TH17

A

Neutrophil recruitment – Rheumatoid Arthritis

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4
Q

TH1

A

Interferon Gamma (y) – Rheumatoid Arthritis

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5
Q

RANKL

A

Rheumatoid Arthritis

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6
Q

TNF

A

Rheumatoid Arthritis

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7
Q

Anti-Citrullinated Peptide Antibodies (ACPA)

A

Rheumatoid Arthritis (Specific)

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8
Q

COL2A1 gene

A

Familial Osteoarthritis

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9
Q

WNT signalling, Prostaglandin pathways

A

Osteoarthritis

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10
Q

Caplans Syndrome

A

Rheumatoid arthritis (RA) and pneumoconiosis combination.

Manifests as intrapulmonary nodules, which appear homogenous and well-defined on chest X-Ray

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11
Q

Felty’s Syndrome

A

Combination of heumatoid arthritis, splenomegaly and neutropenia.

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12
Q

ANA

A

Oligoarthritis (Juvenile Idiopathic Arthritis Subtype)

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13
Q

RF+

A

Polyarthritis (Juvenile Idiopathic Arthritis Subtype)
Ddx
10% of Psoriatic Arthritis

Sjogrens (75%)

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14
Q

Stills Disease

A

Systemic Onset JIA

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15
Q

HLA-B27

A

95% w/Ankylosing spondylitis are HLA-B27+
8% of Caucasian population = HLA-B27+

80% w/Reactive Arth/Reiters are HLA-B27+

Enteropathic Arthritis w/sacroiliitis or spondylitis

Psoriatic Arthritis

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16
Q

HLA-CW6

A

Psoriatic Arthritis

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17
Q

HLA-B8

A

Sjogrens

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18
Q

HLA-DR3

A

Sjogrens

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19
Q

Anti-Ro

A

Sjogrens (90%) also RF (75%)

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20
Q

Lip Biopsy in Sjogrens

A

Periductal and perivascular CD4+ TH cells, B cells, plasma cells , fibrosis

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21
Q

Anti-La

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A

Sjogrens (60-90%)

SLE (10-15%)

22
Q

MPO-ANCA

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A

Anti-myeloperoxidase ANCA

=Microscopic PolyAngiitis
&
=Churg-Strauss Δ
- necrotising vasculitis
- asthma
- allergic rhinitis
- pulmonary infiltrates
- increased circulating eosinophils
- necrotizing granulomas (extrvascular)
23
Q

PR3-ANCA

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A 
Anti-proteinase-3 ANCA
= Wegener’s Granulomatosis
- Upper airways (necrotising granulomas)
- Necrotising granulomatous vasculitis (small-medium vessels)
- Necrotising glomerulonephritis
24
Q

FcR-bearing cells (T-Cells – primarily Cytotoxic)

Study These Flashcards
A

Accelerated Acute Rejection

25
Anti-CD20
Treatment used in humoral acute rejection. On CD4 staining. Also seen = Polyconal Immunoglobulin, Plasmapharesis
26
Minor histocompatibility antigens Non-MHC encoded polymorphisms Cytokine polymorphisms
Mechanism of GVHD which avoid “Matching” Occasionally seen in autologous transplants die t re-emergence of autoreactive t-cells
27
HLA-DRB1*04
Polymyalgia Rheumatica
28
HLA-DRB1*01
Polymyalgia Rheumatica
29
P-ANCA, purpura, lungs, kidneys, cvs, git, necrotizing glomerular nephritis, exogenous antigens from drugs , blood and infections.
Microscopic Polyangitis
30
Triad: Renal Disease Chronic Sinusitis Pneumonitis ANCA+
Wegner’s Granulomatosis (Tx = Rapid Immunosup)
31
Typically affects vessels of respiratory tract, strongly associated with asthma, eosinophilia and pulmonary infiltrates. May also have GI Sx (e.g. colitis, bleeding) +/- cardiac +/- peripheral neuropathy Sx’s. P-ANCA+ and IgE
Churg-Straus Syndrome (Tx = Glucocortiocids +Support)
32
``` Anti-nuclear antibody (ANA) Anti-dsDNA antibody ENA antibodies Anti-RBC antibody Anti-cardiolipin & lupus anticoagulant ```
All auto-antibodies of Systemic Lupus Erythematous
33
Anti-Sm (30%) Anti-Ro (30%) Anti-La
30% specific (except La) each for SLE | All are anti-ENA (extractable nuclear antigen).
34
Jo-1
30% of Polymyosistitis
35
RNP
100% Mixed Connective Tissue Disease
36
Scl-70
A poor prognostic indicator for Scleroderma.
37
IgA immune complexes deposited in mesangium.
IgA nephropathy.
38
Anti-GBM antibody
Goodpastures
39
Anti-CCP
Rheumatoid Arthritis
40
DR4 and DR1
Rheumatoid Arthritis
41
Principle Antibodies in Rheumatoid Arthritis
``` Anti CCP (Specific 97%, sensitive 88%) RF (Specific 65%, Sensitive 50-90%) ```
42
Anti-PR3+
Granulomatosis with Polyangitis (GPA)
43
Anti-ACHr (receptor)
Myasthenia Gravis
44
Anti-MUSK (muscle specific tyrosine kinase)
Found in some anti-AchR negative MG
45
IgA EMA
``` Coeliac (90-100% sensitive and specific) Dermatitis herpetiformis (50-70% sensitive, 90-100 specific) ``` False negative – gluten free diet
46
Dx of Multiple Myeloma
Monoclonal expansion of paraprotein secreting plasma cells in bone marrow IgG 60% of cases IgA 20% of cases Light chains alone 15-20% of cases
47
NADPH oxidase (Phox)
Chronic Granulomatous Disease
48
CD11a, 11b, 11c and CD18
Adhesion molecules (Neutrophil Function Disorder)
49
Atophy
``` Type 1 IgE mediated allergy (most common allergy) 10% population. - Asthma - Hay Fever - Eczema - Foods - Urticaria and angioedema - Anaphylaxis ```
50
Type 2 Allergy
Autoantibody
51
Type 4
Patch Test (Angry Back Syndrome)
52
Graft Rejection Pathophysiology
APC-TCR = CD4 proliferation, release of IL2 and recruitment of Cytotoxic CD8+Tcells

immunopath (3 decks)

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