Immunopathology Lec1

Question 1

Redness

Answer 1

Rubor

Question 2

Tumor

Answer 2

Swelling

Question 3

Pain

Answer 3

Dolor

Question 4

Loss of function

Answer 4

Functio laesa

Question 5

Macrophages kill and eat but don’t digest themselves the ___________.

Answer 5

Present

Question 6

Causes vasodilation and increases vascular permeability

Answer 6

Histamine

Question 7

Causes vasodilation and increased vascular permeability

Answer 7

Serotonin

Question 8

Pain and vasodilation (increases leakyness)

Answer 8

Bradykinin

Question 9

What are the effects of bradykinin?

Answer 9

Vasodilation
PAIN!
Increased vascular permeability
Bronchoconstruction

Question 10

C5a and IL8 are __________________ attractants

Answer 10

Neutrophil

Question 11

What causes degranulation of mast cells?

Answer 11

Anaphylatoxins (C3a and C5a)

Question 12

THis causes pain and fever.

Answer 12

PGE2

Question 13

What neutralizes Thromboxane A2?

Answer 13

Aspirin

Question 14

Lipoxygenase pathway in Lungs involve what that leads to inflammation and bronchoconstriction in Asthma?

Answer 14

Leukotrienes

Question 15

These don’t have a nucleus therefore they cant regenerate TXA2.

Answer 15

Platelets

Question 16

___________ causes liver to make acute phase reactants.

Answer 16

IL-6

Question 17

These cytokines activate endothelial cell adhesion molecules, initiate PGE2 synthesis in anterior hypothalamus, leading to production of fever and pain.

Answer 17

IL-1 and TNFalpha

Question 18

This cytokines does PMN chemotaxis

Answer 18

IL-8

Question 19

What are 4 outcomes of Acute inflammation:

Answer 19

Complete resolution with regeneration
Complete resolution with scarring
Abscess formation
Transition to chronic inflammation

Question 20

Know the difference between conjunctivitis and scleritis…

Answer 20

Both cause red eye, if sclera is inflamed it will be painful…. Conjunctivitis itches and isn’t pain.

Question 21

Important cells for chronic inflammation: 
Macrophages
Histiocytes
Kupffer cells
Osteoclasts
Micoglia

Answer 21

Macrophages: monocytes
HIstiocytes: connective tissues
Kupffer cells: liver
Osteoclasts: bone
Micoglia: brain

Question 22

What play a key role in parasitic infections and IgE-mediated allergic reactions.

Answer 22

Eosinophils

Question 23

Eosinophils contain ___________________, which is toxic to parasites.

Answer 23

Major basic protein

Question 24

WHat are the 4 types of necrosis?

Answer 24

Coagulative
Liquefactive
Caseous
Fat

Question 25

Ischemia is usually ________________ necrosis, but in the brain it is ________________ necrosis.

Answer 25

Coagulative | Liquefactive

Question 26

Liquefaction in most of the body is caused by infection from organisms, but not in the ___________.

Answer 26

Brain

Question 27

"Cheesy" proteinaceous dead cell mass

Answer 27

Caseous necrosis

Question 28

This is death in adipose tissue... small white lesions are formed in subcutaneous tissue because of trauma.

Answer 28

Fat necrosis

Question 29

This is critical in fine-tuning the developing retina.

Answer 29

Apoptosis

Question 30

Well organized destruction of cells

Answer 30

Apoptosis