IMMUNOPATHOLOGY OF THE GIT

Question 1

The Normal Immune mechanisms of the GIT can be divided into

Answer 1

1) Innate Immune mechanisms
2) Specific immune mechanisms

Question 2

Describe the innate Normal immune mechanisms of the GIT

Answer 2

The innate mechanisms include
1) Acid pH of stomach
2) Physical barrier by epithelial cells
3) Mucus production
4) Motility of the GIT
5) Presence of Normal microflora

Question 3

Describe the specific immune mechanisms

Answer 3

This includes the GALT

Question 4

Describe Autoimmune gastritis.

Answer 4

Inflammatory disorder in which the immune system attacks the parietal and chief cells

In the parietal cell the autoantibody is against the gastric proton pump (H+,K+ ATP) and IF

The lack IF leads to VB12 deficiency (pernicious anemia)

Question 5

what is the function of parietal cells

Answer 5

Release of HCL and IF

Question 6

In acute gastritis , the absence of HCL leads to the hypersecretion of

Answer 6

Gastrin and hyperplasia of the G cells