Immunoproliferative Disorders : Waldenstrom Primary Macroglobulinemia (Macroglobulinemia)

Question 1

what type of disorder is Macroglobulinemia

what is it characterised by

Answer 1

B cell disorder characterized by lymphoplasmacytic cell infiltration of the bone marrow and an IgM monoclonal gammopathy

Question 2

what do 20% of patients have (regarding cause of macroglobulinemia)

Answer 2

familial predisposition to the disease and other B cell malignancies

Question 3

what virus’ exposure can increase risk of macroglobulinemia

Answer 3

Hep B and HIV

Question 4

what disease accounts for 10-15% of monoclonal gammopathies

Answer 4

Light-Chain Disease

Question 5

what proteins are only produced in Light-Chain Disease

Answer 5

Only κ or λ monoclonal light chains or Bence Jones proteins

Question 6

what is Franklin disease

Answer 6

γ heavy chain disease

Question 7

what is the commonest type of heavy chain gammopathy, and often seen in men of Mediterranean descent

Answer 7

α heavy chain disease

Question 8

what heavy chain disease is rare

Answer 8

Μ heavy chain disease