Immunosuppressants Flashcards
1
Q
What are the 5 immunosuppressant classes?
A
- Calcineurin inhibitors
- mTOR inhibitors
- Cytotoxic antimetabolites
- S1P receptor agent
- Immunosuppressive antibodies
2
Q
What are the 2 calcineurin inhibitors?
A
Ciclosporin, tacrolimus
3
Q
What are the calcineurin inhibitors selective for?
A
T cells
4
Q
What is the mechanism of action of calcineurin inhibitors?
A
They bind to chaperone proteins which then bind to and inhibit calcineurin, preventing dephosphorylation of NF-AT & transcription of cytokine genes
5
Q
What is the main use for calcineurin inhibitors?
A
Inhibit T cell proliferation for
6
Q
A
