Immunosuppressants Mechanism of Action Flashcards Preview

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Flashcards in Immunosuppressants Mechanism of Action Deck (9)
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1
Q

Cyclosporine

A

Calcineurin inhibitor; binds cyclophilin. Blocks T cell activation by preventing IL-2 transcription.

2
Q

Tacrolimus

A

Calcineurin inhibitor; binds FK506 binding protein (FKBP). Blocks T cell activation by preventing IL-2 transcription.

3
Q

Sirolimus (Rapamycin)

A

mTOR inhibitor; binds FKBP. Blocks T cell activationa nd B cell differentiation by preventing IL-2 signal transduction.

4
Q

Basiliximab

A

Monoclonal antibody; blocks IL-2R

5
Q

Azathioprine

A

Antimetabolite precursor of 5-mercaptopurine. Inhibits lymphocyte proliferation by blocking nucleotide synthesis.

6
Q

Glucocorticoids

A

Inhibit NF-kappaB. Suppress both B and T cell function by decreasing transcription of many cytokines.

7
Q

Immunosuppresants do what

A

Block lymphocyte activation and proliferation. Reduce acute transplant rejection by suppressing cellular immunity. Frequently combined to achieve greater efficacy with dec. toxicity. Chronic suppression increases risk of infection and malignancy.

8
Q

Draw out the target map

A

………………

9
Q

What does Azathioprine inhibit

A

Blocks PPRP Amidotransferase